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The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe

Objectif

The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an “Early-Life Exposome” approach.

HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (>300,000 subjects) and registers, to estimate health impacts at the large European scale.

HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.

Champ scientifique

Programme(s)

Thème(s)

Appel à propositions

FP7-ENV-2012-two-stage
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Régime de financement

CP - Collaborative project (generic)

Coordinateur

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Contribution de l’UE
Aucune donnée
Adresse
C ROSSELLO 132 PLANTA 05
08036 Barcelona
Espagne

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Région
Este Cataluña Barcelona
Type d’activité
Research Organisations
Contact administratif
Diana Van Gent (Dr.)
Liens
Coût total
Aucune donnée

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Dernière mise à jour: 6 Mars 2017

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Permalink: https://cordis.europa.eu/project/id/308333/fr

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