Final Report Summary - INTERACT (Counteracting psychosis by optimizing interaction)
In a second step, we developed a real-time and real-world intervention that targeted these mechanisms of stress and reward. The Acceptance-and-Commitment therapy in daily life is a blended intervention that combines face-to-face therapy with a therapist with an app that people use in their normal daily life. A clinical trial in 148 patients in the early stages of psychosis demonstrated feasibility and acceptability. The short- and long-term effectivity of the intervention is still under investigation as is the neural effect of this intervention on stress and reward-related mechanisms. The final data are currently being collected, so the outcome is being expected in the coming months.