Obiettivo Psychotic disorders are amongst the most severe mental disorders. However, current treatments have failed to reduce disability or change the prospects for recovery for patients with a psychotic disorder. In this project, I will investigate an entirely novel therapy, targeting the core vulnerability profile of altered person-environment interactions underlying psychosis, specifically increased stress-reactivity and reduced motivated and goal-directed behaviour. My colleagues and I have developed a digital apparatus, the ‘PsyMate’, allowing real-time interventions for patients with severe mental illness. In this project, the PsyMate will be used to (1)reduce psychotic and emotional reactivity to stress with “detachment and acceptance” exercises in real life situations, and (2)improve motivated and goal-directed behaviour with real-time behavioural activation therapy. In a randomized controlled trial, I will investigate whether this self-management therapy, conducted outside the office in the patient’s real life, is capable of reducing psychotic reactivity to stress and of improving motivated behaviour in participants with an at-risk mental state for psychosis.In order to understand the impact of this intervention in terms of brain plasticity and prediction of response, I will use an experimental medicine approach to investigate the neural effects of the intervention. I will focus particularly on prefrontal dopamine-reactivity as the brain mechanism mediating altered person-environment interactions. In the current study, I will examine prefrontal dopamine reactivity towards positive as well as stressful negative events as the biological process mediating underlying motivated behaviour and environmental reactivity. Furthermore, I will investigate whether a self-management therapy specifically focused at aberrant person-environment interactions alters brain plasticity at the level of prefrontal dopaminergic neurotransmission in persons at risk for psychosis. Campo scientifico medical and health sciencesclinical medicinepsychiatry Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Invito a presentare proposte ERC-2012-StG_20111109 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante KATHOLIEKE UNIVERSITEIT LEUVEN Contributo UE € 724 682,69 Indirizzo OUDE MARKT 13 3000 Leuven Belgio Mostra sulla mappa Regione Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Stijn Delaure (Dr.) Ricercatore principale Inez Yvonne Ronald Germeys (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto KATHOLIEKE UNIVERSITEIT LEUVEN Belgio Contributo UE € 724 682,69 Indirizzo OUDE MARKT 13 3000 Leuven Mostra sulla mappa Regione Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Stijn Delaure (Dr.) Ricercatore principale Inez Yvonne Ronald Germeys (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAETSKLINIKUM AACHEN Partecipazione conclusa Germania Contributo UE € 161 686,18 Indirizzo Pauwelsstrasse 30 52074 Aachen Mostra sulla mappa Regione Nordrhein-Westfalen Köln Städteregion Aachen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Volker Legewie (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITEIT MAASTRICHT Partecipazione conclusa Paesi Bassi Contributo UE € 612 527,13 Indirizzo MINDERBROEDERSBERG 4 6200 MD Maastricht Mostra sulla mappa Regione Zuid-Nederland Limburg (NL) Zuid-Limburg Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Laurent Louwies (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
