Skip to main content

"Modeling Assays Platform ""MAP"" for hazard ranking of engineered nanoparticles (ENPs)"

Objective

MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational “Modelling Assay Platform (MAP)” which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype – on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modeling Package (CMP) based on structural, mechanistic, as well as kinetic modeling tools and (2) an innovative screening (IS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models.

First a series of classification algorithms will be applied to identify MeNPs with similar toxicity patterns, then computational modelling tools will be developed to establish a more rational relationship between MeNPs descriptors and their toxicity in a dynamic and quantitative way. An in-vitro/in-vivo IS paradigm will be developed as a scalable assessment tool to calibrate and validate the predictive power of the CMP using subsets of the training set or independent set of MeNPs (validation set) respectively.

Call for proposal

FP7-NMP-2012-SMALL-6
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
3000 Leuven
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 537 360
Administrative Contact
Tine Heylen (Mrs.)

Participants (3)

RHENOVIA PHARMA

Participation ended

France
EU contribution
€ 222 491,50
Address
Rue Marc Seguin 40
68100 Mulhouse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Serge Bischoff (Dr.)
GENEDATA AG
Switzerland
EU contribution
€ 240 148,50
Address
Margarethenstrasse 38
4053 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timo Wittenberger (Dr.)
National Health Research Institutes
Taiwan
Address
Keyan Road 35
35053 Zhunan
Activity type
Research Organisations
Administrative Contact
Pinpin Lin (Dr.)