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"Modeling Assays Platform ""MAP"" for hazard ranking of engineered nanoparticles (ENPs)"

Objetivo

MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational “Modelling Assay Platform (MAP)” which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype – on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modeling Package (CMP) based on structural, mechanistic, as well as kinetic modeling tools and (2) an innovative screening (IS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models.

First a series of classification algorithms will be applied to identify MeNPs with similar toxicity patterns, then computational modelling tools will be developed to establish a more rational relationship between MeNPs descriptors and their toxicity in a dynamic and quantitative way. An in-vitro/in-vivo IS paradigm will be developed as a scalable assessment tool to calibrate and validate the predictive power of the CMP using subsets of the training set or independent set of MeNPs (validation set) respectively.

Convocatoria de propuestas

FP7-NMP-2012-SMALL-6
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Coordinador

KATHOLIEKE UNIVERSITEIT LEUVEN
Dirección
Oude Markt 13
3000 Leuven
Bélgica
Tipo de actividad
Higher or Secondary Education Establishments
Aportación de la UE
€ 537 360
Contacto administrativo
Tine Heylen (Mrs.)

Participantes (3)

RHENOVIA PHARMA

La participación finalizó

Francia
Aportación de la UE
€ 222 491,50
Dirección
Rue Marc Seguin 40
68100 Mulhouse
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Serge Bischoff (Dr.)
GENEDATA AG
Suiza
Aportación de la UE
€ 240 148,50
Dirección
Margarethenstrasse 38
4053 Basel
Tipo de actividad
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contacto administrativo
Timo Wittenberger (Dr.)
National Health Research Institutes
Taiwán
Dirección
Keyan Road 35
35053 Zhunan
Tipo de actividad
Research Organisations
Contacto administrativo
Pinpin Lin (Dr.)