"Modeling Assays Platform ""MAP"" for hazard ranking of engineered nanoparticles (ENPs)"

Projektinformationen

MOD-ENP-TOX

ID Finanzhilfevereinbarung: 310715

Abgeschlossenes Projekt

Startdatum 1 Januar 2013

Enddatum 31 Dezember 2015

Finanziert unter

• Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Gesamtkosten € 1 385 241,20

EU-Beitrag € 1 000 000,00

Koordiniert durch

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

Ziel

MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational “Modelling Assay Platform (MAP)” which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype – on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modeling Package (CMP) based on structural, mechanistic, as well as kinetic modeling tools and (2) an innovative screening (IS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models.

First a series of classification algorithms will be applied to identify MeNPs with similar toxicity patterns, then computational modelling tools will be developed to establish a more rational relationship between MeNPs descriptors and their toxicity in a dynamic and quantitative way. An in-vitro/in-vivo IS paradigm will be developed as a scalable assessment tool to calibrate and validate the predictive power of the CMP using subsets of the training set or independent set of MeNPs (validation set) respectively.

Wissenschaftliches Gebiet

• engineering and technology › nanotechnology › nano-materials

Programm/Programme

• FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies

Thema/Themen

• NMP.2012.1.3-2 - Modelling toxicity behaviour of engineered nanoparticles

Aufforderung zur Vorschlagseinreichung

FP7-NMP-2012-SMALL-6
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-FP - Small or medium-scale focused research project

Koordinator

KATHOLIEKE UNIVERSITEIT LEUVEN

Kontakt Verwaltung

Tine Heylen (Mrs.)

• EU-Beitrag: € 537 360,00
• Adresse: OUDE MARKT 13 ; 3000 Leuven ; Belgien
• Region: Vlaams Gewest › Prov. Vlaams-Brabant › Arr. Leuven
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten

Beteiligte (3)

RHENOVIA PHARMA

Beteiligung beendet

Frankreich

Kontakt Verwaltung

Serge Bischoff (Dr.)

• EU-Beitrag: € 222 491,50
• Adresse: RUE MARC SEGUIN 40 ; 68100 MULHOUSE
• Aktivitätstyp: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Gesamtkosten: Keine Daten

GENEDATA AG

Schweiz

Kontakt Verwaltung

Timo Wittenberger (Dr.)

• EU-Beitrag: € 240 148,50
• Adresse: MARGARETHENSTRASSE 38 ; 4053 BASEL
• Aktivitätstyp: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Gesamtkosten: Keine Daten

National Health Research Institutes

Taiwan

Kontakt Verwaltung

Pinpin Lin (Dr.)

• EU-Beitrag: Keine Daten
• Adresse: Keyan Road 35 ; 35053 Zhunan
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten