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"Modeling Assays Platform ""MAP"" for hazard ranking of engineered nanoparticles (ENPs)"

Ziel

MOD-ENP-TOX project is a multidisciplinary project aiming to accomplish the following objectives: (i) to develop a novel and rational “Modelling Assay Platform (MAP)” which can be used as a « Risk Indicator » tool to predict the toxicity of metal-based NPs (MeNPs), and (ii) to demonstrate the feasibility of a MAP prototype – on a shortlist of MeNPs - which can be further developed to screen the toxicity of a large number ENPs. Based on the concept of Integrating Testing Strategies (ITS), the proposed generic MAP combines two main and complimentary paradigms: (1) a novel Computational Modeling Package (CMP) based on structural, mechanistic, as well as kinetic modeling tools and (2) an innovative screening (IS) strategy that allows performing multiplexed streamlined assays for calibration, refinement and validation of the computed models.

First a series of classification algorithms will be applied to identify MeNPs with similar toxicity patterns, then computational modelling tools will be developed to establish a more rational relationship between MeNPs descriptors and their toxicity in a dynamic and quantitative way. An in-vitro/in-vivo IS paradigm will be developed as a scalable assessment tool to calibrate and validate the predictive power of the CMP using subsets of the training set or independent set of MeNPs (validation set) respectively.

Aufforderung zur Vorschlagseinreichung

FP7-NMP-2012-SMALL-6
Andere Projekte für diesen Aufruf anzeigen

Koordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Adresse
Oude Markt 13
3000 Leuven
Belgien

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Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Tine Heylen (Mrs.)
EU-Beitrag
€ 537 360

Beteiligte (3)

RHENOVIA PHARMA

Beteiligung beendet

Frankreich
EU-Beitrag
€ 222 491,50
Adresse
Rue Marc Seguin 40
68100 Mulhouse

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Serge Bischoff (Dr.)
GENEDATA AG
Schweiz
EU-Beitrag
€ 240 148,50
Adresse
Margarethenstrasse 38
4053 Basel

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Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Timo Wittenberger (Dr.)
National Health Research Institutes
Taiwan
Adresse
Keyan Road 35
35053 Zhunan

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Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Pinpin Lin (Dr.)