Final Report Summary - MUTRIPS (Mechanisms Underlying Treatment Responses in Psychosis)
Cognitive control is also impaired in schizophrenia: patients exhibit difficulties across a range of tasks, including planning, learning and social interaction. Cognitive dysfunction in psychosis is largely unresponsive to conventional antipsychotic treatment.
The project demonstrated that cognitive dysfunction lies at the heart of schizophrenia and is instrumental in sustaining both cognitive but also positive symptoms in treatment-resistant patients. These poorly responsive patients may have a different pathoaetiology compared to those that respond to current treatments - based on a greater dysregulation of the glutamatergic rather than the dopaminergic systems.