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TRAINING NETWORK ON ORGANIC OPTOELECTRONICS INTEGRATED WITH LIVING SYSTEMS FOR NEUROSCIENCE INVESTIGATIONS AND APPLICATIONS

Final Report Summary - OLIMPIA (TRAINING NETWORK ON ORGANIC OPTOELECTRONICS INTEGRATED WITH LIVING SYSTEMS FOR NEUROSCIENCE INVESTIGATIONS AND APPLICATIONS)

OLIMPIA is a training network initiative built with the objective to provide training through research and development of innovative organic optoelectronic devices such as OLED, OFET/OLET, OECT, OPD, to be interfaced and integrated with neural cells (glia and neuron).
The major objective of OLIMPIA is to establish an innovative training program aimed at enabling and supporting the development of a novel supradisciplinary field that combines the worlds of organic optoelectronics with the one of neuroscience. To this end the OLIMPIA consortium includes key European players, belonging to 6 European countries from academia, public research centers and industrial labs, with long standing and internationally recognized research tradition in the field of organic electronics and optoelectronics (CNR-ISMN, EMSE, IIT-CNST, TUM) organic synthesis (UPV-EHU) as well as neural cell biology and neurophysiology (IIT-NBT; UIO-CMBN; UNIBO-CNR-ISMN) and, Private Sector Partners in the field of tissue engineering (HISTOCELL) as well as Organics photonics (ETC).
Early stage and experienced researchers enrolled by the programm worked on challenging, intensive, collaborative and highly multidisciplinary research program research projects and obtained experimental data achievieng the following project goals:
• Development and fully characterization of organic optoelectronic devices suitable for operation in physiological aqueous environment.
• Investigation and characterization of thin film structures and organic optoelectronic devices that preserve glial cells and neuron bioelectrical functionality in vitro and/or in vivo.
• Fabrication of organic optoelectronic devices integrated with neural cells capable of providing stimulation and transduction of neural cells bioelectrical activity in vitro and/or in vivo.
• Exploration of the potential application of organic device as diagnostic tool for epilepsy and neuro-regenerative medicine.
The results achieved within the program enable the generation of novel organic bioelectronic and optoelectroni tools to stimulate and to record neuron bioelectrical activity such as organic cell stimulating and sensing transistor structure and organic electrochemical transistor and biohybrid optoelectronic interface to modulate neuron excitability in vitro and to recover blinded retinas function in situ.
The OLIMPIA project prompted novel technological platform targeted to promote radically new understanding of neural cell-cell communication processes and its results will impact on a wide variety of fields, from neuroscience to biomedical research to neuro-regenerative medicine.