Objective BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by design” is based on the application of nanosafety to design the nanomaterials in order to prevent or reduce their possible harm to humans and the environment. The project encompass the synthesis of metal oxide NPs, with a focus on magnetic oxides, their surface modification and post modification in biological fluids; immunological and genotoxicity studies, and translocation studies both “in vitro” and “in vivo”. The project will seek to establish relationships between designed NP properties and their translocation at cellular and body level as well as their immune- and genotoxic response. This is a fundamental issue for the safe design of NPs. Also, the toxicological response will be studied as a function of the uptake dose of NPs. At cellular level a battery of techniques will be applied for localization and quantification of NPs: Transmission Electron Microscopy, Raman, Confocal Microscopy, Ion Beam Microscopy, etc. Positron Emission Tomography and Magnetic Resonance Imaging will be employed for biodistribution and quantification studies in animal models. BRASINOU is formed by an international team with the required and complementary expertise to address the proposed work from an international and multidisciplinary perspective. The project gathers internationally recognized groups in immunology, genotoxicity, nanoparticle synthesis, surface chemistry, biophysics, imaging and materials science. The complementary of the groups involved in the project will help to develop new highly skilled professional and scientific horizontal connections. Fields of science natural scienceschemical sciencesinorganic chemistryinorganic compoundsnatural sciencesphysical sciencesopticsmicroscopyelectron microscopynatural sciencesbiological sciencesbiophysicsnatural sciencesphysical sciencesopticsmicroscopyconfocal microscopyengineering and technologynanotechnologynano-materials Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2012-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-2012-IRSES See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator UNIVERSITAET LEIPZIG Address Ritterstrasse 26 04109 Leipzig Germany See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Irina Estrela-Lopis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE Spain EU contribution € 199 500,00 Address Paseo miramon 182, parque tecnologico de san sebastian edificio empresarial c 20009 San sebastian See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Administrative Contact Alfonso Egaña (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTYTUT FIZYKI POLSKIEJ AKADEMII NAUK Poland EU contribution € 33 600,00 Address Al lotnikow 32/46 02 668 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Administrative Contact Ewa Mosiniewicz-Szablewska (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TYOTERVEYSLAITOS Finland EU contribution € 65 100,00 Address Topeliuksenkatu 41 b 00250 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Julia Catalán (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data WARSZAWSKI UNIWERSYTET MEDYCZNY Poland EU contribution € 31 500,00 Address Ul. zwirki i wigury 61 02 091 Warszawa See on map Region Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa Activity type Higher or Secondary Education Establishments Administrative Contact Joanna Sobczak (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
