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Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles

Objective

BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by design” is based on the application of nanosafety to design the nanomaterials in order to prevent or reduce their possible harm to humans and the environment. The project encompass the synthesis of metal oxide NPs, with a focus on magnetic oxides, their surface modification and post modification in biological fluids; immunological and genotoxicity studies, and translocation studies both “in vitro” and “in vivo”. The project will seek to establish relationships between designed NP properties and their translocation at cellular and body level as well as their immune- and genotoxic response. This is a fundamental issue for the safe design of NPs. Also, the toxicological response will be studied as a function of the uptake dose of NPs. At cellular level a battery of techniques will be applied for localization and quantification of NPs: Transmission Electron Microscopy, Raman, Confocal Microscopy, Ion Beam Microscopy, etc. Positron Emission Tomography and Magnetic Resonance Imaging will be employed for biodistribution and quantification studies in animal models. BRASINOU is formed by an international team with the required and complementary expertise to address the proposed work from an international and multidisciplinary perspective. The project gathers internationally recognized groups in immunology, genotoxicity, nanoparticle synthesis, surface chemistry, biophysics, imaging and materials science. The complementary of the groups involved in the project will help to develop new highly skilled professional and scientific horizontal connections.

Call for proposal

FP7-PEOPLE-2012-IRSES
See other projects for this call

Coordinator

UNIVERSITAET LEIPZIG
Address
Ritterstrasse 26
04109 Leipzig
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 98 700
Administrative Contact
Irina Estrela-Lopis (Dr.)

Participants (4)

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOMATERIALES- CIC biomaGUNE
Spain
EU contribution
€ 199 500
Address
Paseo Miramon 182, Parque Tecnologico De San Sebastian Edificio Empresarial C
20009 San Sebastian
Activity type
Research Organisations
Administrative Contact
Alfonso Egaña (Mr.)
INSTYTUT FIZYKI POLSKIEJ AKADEMII NAUK
Poland
EU contribution
€ 33 600
Address
Al Lotnikow 32/46
02 668 Warszawa
Activity type
Research Organisations
Administrative Contact
Ewa Mosiniewicz-Szablewska (Dr.)
TYOTERVEYSLAITOS
Finland
EU contribution
€ 65 100
Address
Topeliuksenkatu 41 B
00250 Helsinki
Activity type
Research Organisations
Administrative Contact
Julia Catalán (Dr.)
WARSZAWSKI UNIWERSYTET MEDYCZNY
Poland
EU contribution
€ 31 500
Address
Ul. Zwirki I Wigury 61
02 091 Warszawa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Joanna Sobczak (Mrs.)