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Zawartość zarchiwizowana w dniu 2024-06-18

Translocation and Safe Design of Surface Engineered Metal oxide Nanoparticles

Cel

BRASINOEU aims to study the translocation and nanosafety issues of engineered metal oxide nanoparticles (NPs).The new scientific and technology developments of nanotechnology require a deeper knowledge of the effects of nanotechnology based products on human health. This knowledge is fundamental for the development of nanotechnology and to achieve its full acceptance. The concept of “safe by design” is based on the application of nanosafety to design the nanomaterials in order to prevent or reduce their possible harm to humans and the environment. The project encompass the synthesis of metal oxide NPs, with a focus on magnetic oxides, their surface modification and post modification in biological fluids; immunological and genotoxicity studies, and translocation studies both “in vitro” and “in vivo”. The project will seek to establish relationships between designed NP properties and their translocation at cellular and body level as well as their immune- and genotoxic response. This is a fundamental issue for the safe design of NPs. Also, the toxicological response will be studied as a function of the uptake dose of NPs. At cellular level a battery of techniques will be applied for localization and quantification of NPs: Transmission Electron Microscopy, Raman, Confocal Microscopy, Ion Beam Microscopy, etc. Positron Emission Tomography and Magnetic Resonance Imaging will be employed for biodistribution and quantification studies in animal models. BRASINOU is formed by an international team with the required and complementary expertise to address the proposed work from an international and multidisciplinary perspective. The project gathers internationally recognized groups in immunology, genotoxicity, nanoparticle synthesis, surface chemistry, biophysics, imaging and materials science. The complementary of the groups involved in the project will help to develop new highly skilled professional and scientific horizontal connections.

Zaproszenie do składania wniosków

FP7-PEOPLE-2012-IRSES
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

UNIVERSITAET LEIPZIG
Wkład UE
€ 98 700,00
Adres
RITTERSTRASSE 26
04109 Leipzig
Niemcy

Zobacz na mapie

Region
Sachsen Leipzig Leipzig
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Irina Estrela-Lopis (Dr.)
Linki
Koszt całkowity
Brak danych

Uczestnicy (4)