Final Report Summary - ECOPOD (Environmentally Controlled Polymorphism of non-B DNA structures)
In this project, we systematically investigated influence of non-specific physical-chemical factors on structure of the DNA tetraplexes. Conformational properties of a broad spectrum of G- and C-rich DNA oligonucleotides emulating telomeric and centromeric regions of eukaryotic genomes as well as promoter regions of (onco)genes from human genome were studied under various in vitro and in-vivo/ex vivo conditions. The results obtained in the framework of the project resulted in seven publications in peer-reviewed international journals. The results were also presented at three international conferences in a form of poster presentations and invited lectures. In the framework of the project, independent research group (led by the fellow) has been established at the host institution. The project related topics were embedded into three teaching courses at the host institution. In the project period, 13 students concluded their studies under the supervision of the fellow.