Obiettivo
The vision of BIODOT is a hybrid bio-organic technology for transduction of dynamical phenomena of biosystems in-vitro. The device that will be developed is based on organic ultra thin film transistors integrated with microfluidics. It will respond to subtle changes of the electrostatic charge at the interface between the biosystem in the solution and the organic semiconductor. These changes are due, for instance, to the flow of ions, the adsorption and diffusion of charged or polarisable molecules, the motion of large biomolecules, the activity of cells grown on the organic semiconductor.
The transduction of the dynamical behaviour of:
a) peptides involved in neurological functions,
b) phospholipids and functional membranes,
c) neurons and glia cells will be demonstrated during the project.
The signal will be correlated with dynamical data from fluorescence and scanning probe microscopy, computer simulations and structural techniques at the micro- and nano-scales. The integration of neural cells into this technology will extend the scope of the project towards long-term applications in biomedicine. These and other aspects make BIODOT a project aimed to achieve breakthroughs with respect to the state-of-the-art.
Campo scientifico
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- natural sciencesbiological sciencesbiochemistrybiomolecules
- engineering and technologymaterials engineeringcoating and films
- natural sciencesphysical scienceselectromagnetism and electronicssemiconductivity
- natural sciencesmathematicsapplied mathematicsmathematical model
Argomento(i)
Invito a presentare proposte
FP6-2004-NMP-TI-4
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