Objectif
PEROXISCOPY (peroxisome – microscopy) specifically aims at understanding the principles of de novo peroxisome formation.
Peroxisomes have been discovered relatively recently (in 1954). Consequently, the level of understanding of their biology is relatively weak compared to the knowledge of other organelles. Despite their modest appearance, they are crucially important for cell vitality. Peroxisomes ubiquitously occur in eukaryotes, display an unprecedented versatility of functions and are essential in man.
There are still major gaps in our current knowledge of peroxisome biology. PEROXISCOPY aims to study de novo peroxisome formation from the ER, the most debated topic in the peroxisome field.
I will use correlative light and electron microscopy to detail structure and function of the de novo peroxisome formation machinery, starting from initiation on the ER till maturation of the pre-peroxisome. This research will elucidate fundamental issues regarding the molecular mechanisms behind organelle formation and provides the first contours of this developmental machinery.
My research demands the combined expertise from different disciplines. This will be achieved by international collaborations with scientists from both universities and private sector.
The originality of the proposal is high as it is based on very recent novel groundbreaking findings in the field of the novo peroxisome formation. My project is innovative since I will combine advanced microscopy techniques, which were not used in peroxisome research yet, with established biochemical and mass-spectroscopy methods.
Summarizing, this project offers me an advanced research training, allowing me to mature into a scientist who can cope with the science and technology challenges in the molecular life sciences of the mid-21th century.
Champ scientifique
Thème(s)
Appel à propositions
FP7-PEOPLE-2012-IEF
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Régime de financement
MC-IEF - Intra-European Fellowships (IEF)Coordinateur
9712CP Groningen
Pays-Bas