Obiettivo Severe sepsis is an important complication of infections and one of the leading causes of morbidity and mortality. For the countries of the European Union it is estimated that approximately 600,000 cases and more than 150,000 deaths occur from sepsis per year. Currently, no approved treatment options are available for the therapy of septic shock in humans.This research proposal intends to investigate the acute inflammatory response during experimental sepsis in rodents. Our preliminary data indicate an essential role of the novel ‘mitochondrial anti-viral signaling protein’ (MAVS) during sepsis. Mice with genetic deficiency of MAVS appear to be protected against sepsis. We seek to study, how the effects of MAVS are related to regulation of cytokines, innate and adaptive immune cells, apoptosis, abnormalities in blood coagulation and appearance of cytotoxic factors in the context of experimental sepsis.Such studies will be useful to identify novel molecular mechanisms during sepsis which could ultimately be utilized for the development of effective treatment strategies for sepsis. Campo scientifico social sciencessociologydemographymortalitynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineimmunologymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Invito a presentare proposte FP7-PEOPLE-2012-CIG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-CIG - Support for training and career development of researcher (CIG) Coordinatore UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Contributo UE € 100 000,00 Indirizzo Langenbeckstrasse 1 55131 Mainz Germania Mostra sulla mappa Regione Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Silvia Tschauder (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
