Objectif The principle objective of this proposal is to validate fluorinated glyco-structures as effective carbohydrate mimics for the next frontier in pharmaceutical research. Herein we propose to capitalise on the major advances in statistical data analysis which are unravelling the complexity of mammalian and bacterial “glycospace”. Molecular mimicry is a powerful drug design approach. It is therefore envisaged to develop a focussed programme of research to validate fluorinated glycostructures, and in particular 2-fluoro sugars, as carbohydrate mimics for chemical biology, exploiting the ubiquitous role of carbohydrates in molecular recognition. Salient features of the 2-fluoro substituent include (i) enhanced hydrolytic stability to enzymatic degradation, (ii) the presence of a NMR active reporter nucleus (19F) for facile analysis, and (iii) the possibility for molecular imaging application when using 18F labelled glycostructures. Phase one of this project will aim to develop synthetic routes to the target fluoro-glycostructures. This will involve a substantial component of physical organic chemistry including conformational analysis, advanced 19F NMR spectroscopy and the possible isolation of oxo-carbenium analogues by exploiting advances in the development of large, weakly co-ordinating anions. From first principle reaction design and development, through a basic understanding of conformation and reactivity, phase 2 will focus on the application of these materials for chemical biology applications. Phase 2 will then heavily focus on the application of complex oligosaccharides containing the PET active 18F moiety. It is envisaged that by exploiting the ubiquitous role of carbohydrates in molecular recognition that this would conceivably lead to the development of selective imaging agents, thus bypassing the current problem of relying on the metabolically controlled distribution of the commonly used PET tracer 2-fluorodeoxy glucose (18F-FDG). Champ scientifique natural sciencescomputer and information sciencesdata sciencenatural scienceschemical sciencesorganic chemistrymedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Appel à propositions ERC-2013-StG Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil UNIVERSITAET MUENSTER Contribution de l’UE € 1 253 880,00 Adresse SCHLOSSPLATZ 2 48149 MUENSTER Allemagne Voir sur la carte Région Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Katharina Steinberg (Dr.) Chercheur principal Ryan Gilmour (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITAET MUENSTER Allemagne Contribution de l’UE € 1 253 880,00 Adresse SCHLOSSPLATZ 2 48149 MUENSTER Voir sur la carte Région Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Katharina Steinberg (Dr.) Chercheur principal Ryan Gilmour (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée