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Bridging the Evolution and Epidemiology of HIV in Europe

Obiettivo

The aim of the BEEHIVE project is to generate novel insight into HIV biology, evolution and epidemiology, leveraging next-generation high-throughput sequencing and bioinformatics to produce and analyse whole-genomes of viruses from approximately 3,000 European HIV-1 infected patients. These patients have known dates of infection spread over the last 25 years, good clinical follow up, and a wide range of clinical prognostic indicators and outcomes. The primary objective is to discover the viral genetic determinants of severity of infection and set-point viral load. This primary objective is high-risk & blue-skies: there is ample indirect evidence of polymorphisms that alter virulence, but they have never been identified, and it is not known how easy they are to discover. However, the project is also high-reward: it could lead to a substantial shift in the understanding of HIV disease.

Technologically, the BEEHIVE project will deliver new approaches for undertaking whole genome association studies on RNA viruses, including delivering an innovative high-throughput bioinformatics pipeline for handling genetically diverse viral quasi-species data (with viral diversity both within and between infected patients).

The project also includes secondary and tertiary objectives that address critical open questions in HIV epidemiology and evolution. The secondary objective is to use viral genetic sequences allied to mathematical epidemic models to better understand the resurgent European epidemic amongst high-risk groups, especially men who have sex with men. The aim will not just be to establish who is at risk of infection, which is known from conventional epidemiological approaches, but also to characterise the risk factors for onwards transmission of the virus. Tertiary objectives involve understanding the relationship between the genetic diversity within viral samples, indicative of on-going evolution or dual infections, to clinical outcomes.

Invito a presentare proposte

ERC-2013-ADG
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Meccanismo di finanziamento

ERC-AG - ERC Advanced Grant

Istituzione ospitante

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Indirizzo
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom
Tipo di attività
Higher or Secondary Education Establishments
Contributo UE
€ 923 498,03
Ricercatore principale
Christopher Fraser (Prof.)
Contatto amministrativo
Gill Wells (Ms.)

Beneficiari (4)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contributo UE
€ 923 498,03
Indirizzo
Wellington Square University Offices
OX1 2JD Oxford
Tipo di attività
Higher or Secondary Education Establishments
Ricercatore principale
Christopher Fraser (Prof.)
Contatto amministrativo
Gill Wells (Ms.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Paesi Bassi
Contributo UE
€ 893 109,26
Indirizzo
Meibergdreef 15
1105AZ Amsterdam
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Gulseren Yalvac (Ms.)
GENOME RESEARCH LIMITED
United Kingdom
Contributo UE
€ 218 373,26
Indirizzo
The Gibbs Building, Euston Road 215
NW1 2BE London
Tipo di attività
Research Organisations
Contatto amministrativo
David Davison (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Contributo UE
€ 464 758,80
Indirizzo
South Kensington Campus Exhibition Road
SW7 2AZ London
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Scott Wheatley (Mr.)