Final Activity Report Summary - DIVAS (Domain Integrity Verification of Alternative Splicing using statistical methods and molecular modeling)
Expanding this data set to include all the named variants in Swissprot we gained a lot of insight into the nature of alternative splicing and concluded that it is basically governed by two rules: 1. Validated alternative splicing (with a surviving protein isoform) occurs mostly in disordered regions and tends to avoid globular domains; 2. If the splicing does truncate a globular domain it is usually marginal (less than 10% of the domain is removed by the truncation event) or the resulting sub-domain has the characteristics of an intact domain regarding the newly exposed hydrophobic surface area.