Ziel
The emergence and evolution of antibiotic resistance in bacteria represents a major financial and societal cost. Despite concern that the use of antibiotics in the food chain contributes to the development of resistant bacteria, research has yet to provide the data necessary for the development of an effective risk management strategy. Risk assessment of antibiotic resistant, nonpathogenic bacteria present in the food chain requires data on the sources of these bacteria, their genetic composition and potential for resistance transfer. This project, named Assessment and Critical Evaluation of Antibiotic Resistance Transferability in Food Chain (ACE-ART) will provide a critical evaluation of the role of antibiotic use in agriculture and in the prophylaxis and treatment of disease in humans. Unlike other studies, focused on pathogens, this project is focused on non-pathogenic bacteria. Strains belonging to Lactobacillus, Bifidobacterium, Lactococcus and Streptococcus thermophilus will be used as they can be found in a wide range of habitats. Moreover, they are industrially important bacteria, used as starter cultures for fermented food. Within this project the importance of these bacteria as a source of antibiotic resistance genes (Work package 1) will be assessed. The project will also examine the transmission of resistance in the environment and in the animal and human gut (WP 2) and establish the genetic basis of the detected resistances and transmission mechanisms (WP 3). Dissemination of results and links with consumers' organization will be provided by WP4; an industrial platform will assure the link with 14 industrial producers of starter cultures. This research will establish a dataset on the occurrence and transmission of antibiotic resistance, which will provide the scientific basis for an antibiotic application strategy to inhibit further development of resistance in pathogenic bacteria'.
Wissenschaftliches Gebiet
CORDIS klassifiziert Projekte mit EuroSciVoc, einer mehrsprachigen Taxonomie der Wissenschaftsbereiche, durch einen halbautomatischen Prozess, der auf Verfahren der Verarbeitung natürlicher Sprache beruht.
CORDIS klassifiziert Projekte mit EuroSciVoc, einer mehrsprachigen Taxonomie der Wissenschaftsbereiche, durch einen halbautomatischen Prozess, der auf Verfahren der Verarbeitung natürlicher Sprache beruht.
- medical and health sciencesmedical biotechnologygenetic engineeringgene therapy
- natural scienceschemical sciencesorganic chemistryorganic acids
- natural sciencesbiological sciencesmicrobiologybacteriology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Schlüsselbegriffe
Programm/Programme
Aufforderung zur Vorschlagseinreichung
FP6-2002-FOOD-1
Andere Projekte für diesen Aufruf anzeigen
Finanzierungsplan
NoE - Network of ExcellenceKoordinator
MILANO
Italien