Objectif
Modern science has showed that heating of meat and other protein rich foods can generate various kinds of potentially hazardous compounds, some of which are genotoxic and carcinogenic. The focus of the HEATOX project, which is an international collaboration, is health risks recently discovered associated with hazardous compounds in heat treated carbohydrate-rich foods where substantial amounts of acrylamide and similar compounds can be formed. HEATOX will explore their mechanisms of formation, impact of raw material composition, inhibiting factors, cooking and processing methods in industry and households with the to control and minimise the formation of hazardous compounds. Acrylamide is given particular emphasis, however, it is likely that also other compounds such as b unsaturated carbonyl compounds and furans, representing potential health hazards, are formed during heating. It is important that efforts in reducing acrylamide exposure at the same time don not increase the formation of other hazardous compounds. To reduce the exposure, validated methods for food analysis and exposure biomarkers will be developed. Different hazards will be explored and characterised in various toxicological models, e.g. genotoxicity, carcinogenicity, neuro-developmental and reproductive toxicity. Molecular characterisation by toxicogenomics - will be performed. Both experimental animal- and cell systems and also humans will be studied. Particularly the relevance of low dose exposure, bioavailability and extrapolation from experimental systems to humans will be addressed using biomarkers of exposure and effect such as haemoglobin adducts, assessment of DNA binding using accelerator mass spectrometry and a hypersensitive micronucleus assay measuring genotoxicity. The exposure assessment and data on hazard characterisation, including data generated outside HEATOX, will be combined in a risk characterisation of intake heat-treated carbohydrate rich foods.
Champ scientifique
- engineering and technologymaterials engineeringcolors
- engineering and technologyother engineering and technologiesfood technologyfood safety
- natural sciencesbiological sciencesbiochemistrybiomoleculescarbohydrates
- agricultural sciencesagriculture, forestry, and fisheriesagriculturehorticulturevegetable growing
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
Mots‑clés
Appel à propositions
FP6-2002-FOOD-1
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Régime de financement
NoE - Network of ExcellenceCoordinateur
117 LUND
Suède
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Participants (25)
GRAZ
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READING
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7070 UPPSALA
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BOLOGNA
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5401 GOTHENBURG
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8129 WAGENINGEN
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LONDON
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622 UPPSALA
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PRAHA 6
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WAGENINGEN
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BARCELONA
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KOCAELI
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STOCKHOLM
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SOEBORG
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4404 Nydalen OSLO
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WAGENINGEN
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BERGHOLZ-REHBRUECKE
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LEEDS
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BRUSSELS
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8156Dep. OSLO
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ZÜRICH
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SANTIAGO
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BELFAST
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COPENHAGEN V
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KGS. LYNGBY
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