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Development of a physiological simulator for cardiovascular devices

Ziel

Heart disease is a major cause of death in the Western world. In the past three decades there have been a number of improvements in artificial devices and surgical techniques for cardiovascular disease; however there is still aneed for novel devices, espec ially for those individuals who cannot receive conventional therapy. The major disadvantage of current artificial devices lies in the fact that they cannot grow, remodel or repair in vivo. Tissue engineering offers the possibility of developing a biologica l substitute material in vitro with the inherent mechanical, chemical, biological and morphological properties required in vivo, on an individual patient basis.In order to develop a true biological cardiovascular device a dynamic physiological environment needs to becreated. The main objective of this research is to develop a physiological simulator capable of mimicking the in-vivo biological, biomechanical and biochemical conditions of the cardiovascular system in-vitro, to predict the biological and mecha nical response of conventional and novel tissue engineered cardiovascular materials invivo. In parallel computational modelling will be applied to predict local cell deformations and models generated will be correlated and assessed with experimental deform ations and biological responses. The results of this study if successful will represent a significant scientific breakthrough, paving the way for future generations of functional biological replacement materials, capable of restructuring and remodelling in -vivo. Thereby, offering the possibility of helping thousands of people who suffer from cardiovascular disease.

Wissenschaftliches Gebiet (EuroSciVoc)

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP6-2002-MOBILITY-3
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

TOK - Marie Curie actions-Transfer of Knowledge

Koordinator

NATIONAL UNIVERSITY OF IRELAND, GALWAY
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