Ziel
In Plasmodium and Mycobacterium, isoprenoids are synthesised by the mevalonate-independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway which is absent in humans. The last two steps of the DOXP pathway are mediated by enzymes which contain oxygen-sensiti ve iron-sulphur clusters and catalyse unique radical-type reactions. Using an advanced High Resolution Screening technology the project aims at the identification of lead inhibitors to be developed as novel drugs against malaria and tuberculosis.
Wissenschaftliches Gebiet
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health scienceshealth sciencesinfectious diseasesmalaria
- medical and health sciencesbasic medicinemedicinal chemistry
- medical and health sciencesclinical medicinepneumologytuberculosis
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
Schlüsselbegriffe
Programm/Programme
Aufforderung zur Vorschlagseinreichung
FP6-2003-LIFESCIHEALTH-3
Andere Projekte für diesen Aufruf anzeigen
Finanzierungsplan
STIP - Specific Targeted Innovation ProjectKoordinator
GIESSEN
Deutschland