Obiettivo Thrombotic stroke is a disabling condition - affecting an estimated 650,000 Europeans annually, with considerable mortality and costing over ¬30 billion/yr. Genetic factors account for a substantial component of the incidence & mortality of stroke. There is little effective therapy. EUROCLOT aims to identify and validate potentially therapeutically useful genes associated with thrombotic stroke using a novel approach. Stroke is a complex end-point disease involving the interaction of many pathologic processes, such as vessel wall atheroma, hypertension, platelet function & coagulation. EUROCLOT focuses on uncovering the genes that control the end-stage of the coagulation process that leads directly to the production of the thrombus (clot) that causes vascular obstruction and tissue death. Clinical studies indicate that alterations in fibrin structure and/or function create a prothrombotic phenotype which increases vascular risk. Twin studies have shown a substantial genetic component to levels of activation peptides and the final common pathway of thrombus (fibrin structure/function). We aim specifically to identify the major genes involved in variations of the end-stage clotting process and investigate the role of these novel genes (and existing candidate genes) in the pathogenesis of stroke across Europe. EUROCLOT will study stroke intermediate phenotypes in 4500 twins from GenomEUtwin project involving 8 countries and 1000 subjects from extended families from the GAIT2 (Spain) and EuroHead (Finland) studies. Genes will be validated in 1500 stroke cases including those from the large European prospective MORGAM study. Cross-European differences in allelic frequencies will be examined along with their relative impacts. Phenotyping will be standardised and harmonised and a European database established. Close links with European SMEs will ensure that all findings from EUROCLOT are maximally exploited to develop future novel diagnostics and therapeutic targets. Campo scientifico social sciencessociologydemographymortalitynatural sciencescomputer and information sciencesdatabasesnatural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health sciencesbasic medicineneurologystroke Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2003-2.1.1-6 - Molecular basis of vascular events leading to thrombotic stroke Invito a presentare proposte FP6-2003-LIFESCIHEALTH-I Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore KING'S COLLEGE LONDON Contributo UE Nessun dato Indirizzo Strand LONDON Regno Unito Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF LEEDS Regno Unito Contributo UE Nessun dato Indirizzo Woodhouse Lane LEEDS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato LEIDEN UNIVERSITY MEDICAL CENTER Paesi Bassi Contributo UE Nessun dato Indirizzo Albinusdreef 2 9600 LEIDEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato HELSINGIN YLIOPISTO Finlandia Contributo UE Nessun dato Indirizzo Yliopistonkatu 4 HELSINGIN YLIOPISTO, HELSINKI Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato QUEENS'S UNIVERSITY BELFAST' Regno Unito Contributo UE Nessun dato Indirizzo University Road BELFAST Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ISTITUTO SUPERIORE DI SANITÀ Italia Contributo UE Nessun dato Indirizzo Viale Regina Elena, 299 ROME Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato KAROLINSKA INSTITUTET Svezia Contributo UE Nessun dato Indirizzo Solna v. 1 STOCKHOLM Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THROMBOSIS AND HAEMOSTASIS UNIT, HOSPITAL DE LA SANTA CREU I SANT PAU Spagna Contributo UE Nessun dato Indirizzo Sant Antoni M Claret, 167 BARCELONA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato GUY'S & ST THOMAS' HOSPITAL NHS TRUST' Regno Unito Contributo UE Nessun dato Indirizzo Lambeth Palace Road LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato