Objetivo Patients with high-risk hematological tumors can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). However, the main causes of failure of HSCT are infections, tumor relapse and over-shooting immune responses of the donor T cells to healthy cells and tissues of the patient or graft-versus host disease (GvHD). Therefore, this treatment is still associated with a high morbidity and mortality, as well as a high economic burden. Our previous EU FP6 project, ALLOSTEM, resulted in a number of achievements, including a ‘first in man’ clinical trial that used a highly innovative novel cell selection strategy (Streptamer technology) for the generation of non-ATMP (advanced therapy medicinal product) monovirus specific T cell products. Continuing from ALLOSTEM, we now aim to develop two novel Streptamer-based clinical cell selection processes and its corresponding cell products. A multispecific T cell product targeting several viruses and tumors as well as a primary regulatory T cell product targeting GvHD will be developed to market maturity. These two cell products will improve the outcome of allogeneic HSCT. A significant improvement in the outcome and this coupled with a significant reduction of the costs for a large number of patients in Europe will further broaden the application in other forms of cancer of this curative treatment. In order to achieve this goal we assembled a consortium led by the University Hospital of Würzburg with Prof. Einsele as scientific coordinator together with renowned clinical scientists in the field of HSCT (all key players in ALLOSTEM). Ámbito científico medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineemergency medicinegraft versus host diseasemedical and health sciencesclinical medicinetransplantation Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2013.0-1 - Boosting the translation of health research projects' results into innovative applications for health Convocatoria de propuestas FP7-HEALTH-2013-INNOVATION-2 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT Aportación de la UE € 1 118 101,00 Dirección JOSEF-SCHNEIDER-STRASSE 2 97080 Wurzburg Alemania Ver en el mapa Región Bayern Unterfranken Würzburg, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Anne Von Thun (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (5) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo ANTHONY NOLAN Reino Unido Aportación de la UE € 925 266,00 Dirección AGINCOURT ROAD 75-87 UNITS 2-3 HEATHGATE PLACE NW3 2NU LONDON Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Alejandro Madrigal (Prof.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos JUNO THERAPEUTICS GMBH Alemania Aportación de la UE € 2 531 268,00 Dirección RUDOLF-WISSELL-STRASS 28 37079 GOETTINGEN Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Lothar Germeroth (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ACADEMISCH ZIEKENHUIS LEIDEN Países Bajos Aportación de la UE € 935 110,00 Dirección ALBINUSDREEF 2 2333 ZA Leiden Ver en el mapa Región West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Frederik Falkenburg (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG La participación finalizó Alemania Aportación de la UE € 115 766,00 Dirección OSKAR VON MILLER RING 29 80333 Muenchen Ver en el mapa Región Bayern Oberbayern München, Kreisfreie Stadt Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Birgit Fuchs (Mrs.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos ARTTIC Francia Aportación de la UE € 57 025,00 Dirección 39 RUE DES MATHURINS 75008 Paris Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Martin Dietz (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos