Objectif Patients with high-risk hematological tumors can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). However, the main causes of failure of HSCT are infections, tumor relapse and over-shooting immune responses of the donor T cells to healthy cells and tissues of the patient or graft-versus host disease (GvHD). Therefore, this treatment is still associated with a high morbidity and mortality, as well as a high economic burden. Our previous EU FP6 project, ALLOSTEM, resulted in a number of achievements, including a ‘first in man’ clinical trial that used a highly innovative novel cell selection strategy (Streptamer technology) for the generation of non-ATMP (advanced therapy medicinal product) monovirus specific T cell products. Continuing from ALLOSTEM, we now aim to develop two novel Streptamer-based clinical cell selection processes and its corresponding cell products. A multispecific T cell product targeting several viruses and tumors as well as a primary regulatory T cell product targeting GvHD will be developed to market maturity. These two cell products will improve the outcome of allogeneic HSCT. A significant improvement in the outcome and this coupled with a significant reduction of the costs for a large number of patients in Europe will further broaden the application in other forms of cancer of this curative treatment. In order to achieve this goal we assembled a consortium led by the University Hospital of Würzburg with Prof. Einsele as scientific coordinator together with renowned clinical scientists in the field of HSCT (all key players in ALLOSTEM). Champ scientifique medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesbasic medicineimmunologymedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineemergency medicinegraft versus host diseasemedical and health sciencesclinical medicinetransplantation Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2013.0-1 - Boosting the translation of health research projects' results into innovative applications for health Appel à propositions FP7-HEALTH-2013-INNOVATION-2 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT Contribution de l’UE € 1 118 101,00 Adresse JOSEF-SCHNEIDER-STRASSE 2 97080 Wurzburg Allemagne Voir sur la carte Région Bayern Unterfranken Würzburg, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Anne Von Thun (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (5) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ANTHONY NOLAN Royaume-Uni Contribution de l’UE € 925 266,00 Adresse AGINCOURT ROAD 75-87 UNITS 2-3 HEATHGATE PLACE NW3 2NU LONDON Voir sur la carte Type d’activité Research Organisations Contact administratif Alejandro Madrigal (Prof.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée JUNO THERAPEUTICS GMBH Allemagne Contribution de l’UE € 2 531 268,00 Adresse RUDOLF-WISSELL-STRASS 28 37079 GOETTINGEN Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Lothar Germeroth (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ACADEMISCH ZIEKENHUIS LEIDEN Pays-Bas Contribution de l’UE € 935 110,00 Adresse ALBINUSDREEF 2 2333 ZA Leiden Voir sur la carte Région West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Type d’activité Higher or Secondary Education Establishments Contact administratif Frederik Falkenburg (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation terminée Allemagne Contribution de l’UE € 115 766,00 Adresse OSKAR VON MILLER RING 29 80333 Muenchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Birgit Fuchs (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ARTTIC France Contribution de l’UE € 57 025,00 Adresse 39 RUE DES MATHURINS 75008 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Martin Dietz (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée