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Integrative Analysis of Gene Functions in Cellular and Animal Models of Pancreatic Cancer

Objective

Cancers are genetic disease arising from the accumulation of multiple molecular alterations in affected cells. Large-scale genomic, transcriptomic and proteomic analyses have established comprehensive catalogues of molecules which are altered in their structure and/or abundance in malignant tumors as compared to healthy tissues. Far less developed are concepts and methods to integrate data from different sources and to directly interrogate gene functions on a large scale in order to differentiate “driver” alterations, which directly contribute to tumor progression, from indolent “passenger” alterations. As a consequence, examples of successful translation of knowledge generated from “omics” approaches into novel clinical concepts and applications are scarce.
Pancreatic cancer is a prime example of this dilemma. Representing the 4th to 5th most common cause of cancer related deaths, it is a disease with a major socioeconomic impact. Despite enormous advances in the identification of molecular changes associated with the disease, new treatment options have not emerged. Thus, 5-year survival rates remain unchanged at a dismal 6%, the lowest for all solid tumors.
Using pancreatic cancer as a model disease, the goal of this integrative project is to develop novel cellular and animal models, as well as novel strategies to generate, analyze and integrate large scale metabolic and transcriptomic data from these models, in order to systematically characterize and validate novel targets for therapeutic intervention. In addition to the general tumor cell population, special consideration will be given to sub-populations of tumor-initiating cells, a.k.a. tumor stem cells.
To this end, the consortium comprises i) SMEs with strong focus on technology development, ii) clinical and academic partners with extensive experience in pancreatic cancer molecular biology and management of pancreatic cancer patients, and iii) technology and data analysis experts from academic groups.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

FP7-HEALTH-2013-INNOVATION-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

PHILIPPS UNIVERSITAET MARBURG
Address
Biegenstrasse 10
35037 Marburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 507 350
Administrative Contact
Lois Woestman (Ms.)

Participants (14)

FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III

Participation ended

Spain
EU contribution
€ 778,44
Address
Calle Melchor Fernandez Almagro 3
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Dolores Liébanes (Ms.)
POLYGENE AG
Switzerland
EU contribution
€ 1 366 700
Address
Riedmattstrasse 9
8153 Rümlang
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Shmerling Doron (Dr.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Participation ended

Germany
EU contribution
€ 260 863,35
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Schaulin (Ms.)
Institut für Bioprozess- und Analysenmesstechnik e.V.
Germany
EU contribution
€ 921 287
Address
Rosenhof 1
37308 Heilbad Heiligenstadt
Activity type
Research Organisations
Administrative Contact
Ulrich Marschall (Mr.)
EXPERIMENTELLE PHARMAKOLOGIE UND ONKOLOGIE BERLIN-BUCH GMBH
Germany
EU contribution
€ 765 000
Address
Robert-roessle-strasse 10
13125 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Diana Behrens (Dr.)
SOVALACC B.V.

Participation ended

Netherlands
Address
Staalmeesterslaan 390
1057PG Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Luxemburg (Mr.)
UNIVERSITA DEGLI STUDI DI VERONA
Italy
EU contribution
€ 1 148 400
Address
Via Dell Artigliere 8
37129 Verona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Enrico Maria Cazzaroli (Dr.)
CEGAT GMBH
Germany
EU contribution
€ 800 071
Address
Paul Ehrlich Strasse 17
72076 Tubingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stefan Ohrnberger (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 805 800
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michaela Schuhmacher (Ms.)
Concentris Research Management GmbH
Germany
EU contribution
€ 499 500
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ameli Schwalber (Dr.)
MIMETAS BV
Netherlands
EU contribution
€ 300 000
Address
Jh Oortweg 19
2333CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jos Joore (Dr.)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 490 000
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ton Brouwer (Mr.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU contribution
€ 1 298 221,56
Address
327 Mile End Road
E1 4NS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Reuben Almeida (Mr.)
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany
EU contribution
€ 1 029 136,65
Address
Im Neuenheimer Feld 280
69120 Heidelberg
Activity type
Research Organisations
Administrative Contact
Julia Stumpf (Mrs.)