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Natural inorganic polymers and smart functionalized micro-units applied in customized rapid prototyping of bioactive scaffolds

Objective

The application of rapid prototyping techniques has become a new trend in the fabrication of customized scaffolds for tissue regeneration or repair. The aim of the proposed project is to provide novel solutions for bottle-neck problems currently faced in establishing the corresponding processing chain, which encounter, among others, the extraction of essential geometry data of the damaged tissue from medical images, e.g. CT and MRI, with a resolution sufficient enough to guide CAD/CAM-based materials manufacturing processes; the establishment of a feasible interfaces between medical imaging, CAD and CAM; and the fabrication, by rapid prototyping techniques, i.e. selective laser sintering, 3D printing and robocasting, of customized scaffolds based on an innovative morphogenetically active bio-inorganic polymer, bio-silica, either alone or in combination with another bio-inorganic polymer, bio-polyP, as well as smart micro-units. Customization of both external geometry and internal cellular architecture, and of the material properties of the scaffolds will be achieved. The main focus is the development of novel osteogenic scaffolds which obviate the need of exogenously added growth factors/cytokines in bone tissue engineering. The scaffolds made of the bioactive bio-inorganic polymers or their composites with traditional bio-ceramics will fulfil both mechanical and physiological requirements for the intended biomedical applications. In addition, this project will provide a new strategy for 3D printing of bone-forming cells by exploiting the unique advantages of cell-encapsulating bio-silica alginate hydrogels. The multidisciplinary consortium proposing this project comprises internationally top-ranked researchers in Europe and in China and includes an already established Joint Lab between European and Chinese partners providing the necessary infrastructure and competence to realize a fast integration and a proof-of-concept within the proposed 3-year funding period.

Field of science

  • /engineering and technology/materials engineering/composites
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /engineering and technology/mechanical engineering/manufacturing engineering/additive manufacturing
  • /natural sciences/chemical sciences/polymer science
  • /natural sciences/mathematics/pure mathematics/geometry
  • /medical and health sciences/clinical medicine/radiology/medical imaging
  • /natural sciences/physical sciences/optics/laser physics

Call for proposal

FP7-NMP-2013-EU-China
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project
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Coordinator

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Address
Langenbeckstrasse 1
55131 Mainz
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 486 620
Administrative Contact
Silvia Tschauder (Dr.)

Participants (4)

VYSOKE UCENI TECHNICKE V BRNE
Czechia
EU contribution
€ 306 515
Address
Antoninska 548/1
601 90 Brno Stred
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karel Maca (Prof.)
UNIVERSIDAD DE EXTREMADURA
Spain
EU contribution
€ 352 822
Address
Avenida De Elvas Sn
06006 Badajoz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luciano Cordero Saavedra (Mr.)
ORTOMA AB
Sweden
EU contribution
€ 292 485
Address
Erik Dahlbergsgatan 11A
411 26 Goteborg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Matts Andersson (Dr.)
NANOTECMARIN GMBH
Germany
EU contribution
€ 360 560
Address
Muhlstrasse 19
55218 Ingelheim Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heinz C Schröder (Prof.)