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Rapid prototyping scaffolds for the nervous system

Objective

Advanced tissue engineering requires scaffolds fabricated at different scales to facilitate cellular repair. Neurons respond to micro and nanopatterns over which are grown and it is possible to control - to some extent - neurite protrusion and the formation of neuronal network by using only nanopatterns. The present proposal is based on four main steps: i - Development and fabrication of Scaffolds; ii - Experimentation and testing of the formation of 3D neuronal networks; iii - Analysis of long term survival of 3D neuronal networks; iv- Development and testing of scaffolds for implants. The final and most important step concerns the implantation of our scaffolds in a neuronal tissue for repair. We will attempt to implant our scaffolds for repairing spinal cord and sciatic nerve injuries, a realistic but challenging aim. Controlled nanoscaled scaffolds will be obtained using nanocomposite materials to obtain custom-designed SFF scaffolds. These scaffolds will be constructed with different materials and will be decorated with appropriate CNTs and/or signaling molecules. Medical imaging will be used to target and interface personalized scaffold production for repair of injuries of the spinal cord and sciatic nerve. In order to achieve these results we have formed a collaboration based on two clusters of research centres, one in China and one in Europe. The cluster in China is composed of the Chinese Academy of Science in Bejing, the Institute of NanoTech and NanoBionics in Suzhou and the Department of Neurosurgery Neurology, Drum Tower Hospital, of the Nanjing University. The cluster in Europe is formed by SISSA in Trieste, the University of Trieste, IIT in Genova, Ecole Normale Supérieure (ENS) in Paris and the University of Lund in Sweden where the repair of the sciatic nerve and the spinal cord will be studied. These two clusters have all the expertise to tackle and reach our objectives.

Field of science

  • /medical and health sciences/basic medicine/neurology
  • /medical and health sciences/medical biotechnology/tissue engineering
  • /medical and health sciences/clinical medicine/radiology/medical imaging
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

FP7-NMP-2013-EU-China
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE
Address
Via Bonomea 265
34136 Trieste
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 486 600
Administrative Contact
Gabriele Rizzetto (Mr.)

Participants (4)

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 353 310
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations
Administrative Contact
Claudia Schiaffino (Ms.)
UNIVERSITA DEGLI STUDI DI TRIESTE
Italy
EU contribution
€ 150 000
Address
Piazzale Europa 1
34127 Trieste
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paolo Balsini (Dr.)
ECOLE NORMALE SUPERIEURE
France
EU contribution
€ 404 880
Address
45, Rue D'ulm
75230 Paris Cedex 05
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Cormier (Mrs.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 404 998
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens Schouenborg (Prof.)