Objectif Advanced tissue engineering requires scaffolds fabricated at different scales to facilitate cellular repair. Neurons respond to micro and nanopatterns over which are grown and it is possible to control - to some extent - neurite protrusion and the formation of neuronal network by using only nanopatterns. The present proposal is based on four main steps: i - Development and fabrication of Scaffolds; ii - Experimentation and testing of the formation of 3D neuronal networks; iii - Analysis of long term survival of 3D neuronal networks; iv- Development and testing of scaffolds for implants. The final and most important step concerns the implantation of our scaffolds in a neuronal tissue for repair. We will attempt to implant our scaffolds for repairing spinal cord and sciatic nerve injuries, a realistic but challenging aim. Controlled nanoscaled scaffolds will be obtained using nanocomposite materials to obtain custom-designed SFF scaffolds. These scaffolds will be constructed with different materials and will be decorated with appropriate CNTs and/or signaling molecules. Medical imaging will be used to target and interface personalized scaffold production for repair of injuries of the spinal cord and sciatic nerve. In order to achieve these results we have formed a collaboration based on two clusters of research centres, one in China and one in Europe. The cluster in China is composed of the Chinese Academy of Science in Bejing, the Institute of NanoTech and NanoBionics in Suzhou and the Department of Neurosurgery Neurology, Drum Tower Hospital, of the Nanjing University. The cluster in Europe is formed by SISSA in Trieste, the University of Trieste, IIT in Genova, Ecole Normale Supérieure (ENS) in Paris and the University of Lund in Sweden where the repair of the sciatic nerve and the spinal cord will be studied. These two clusters have all the expertise to tackle and reach our objectives. Champ scientifique medical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologyimplantsengineering and technologymedical engineeringdiagnostic imagingmedical and health sciencesbasic medicineneurologyengineering and technologymaterials engineeringnanocomposites Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Thème(s) NMP.2013.2.2-2 - Biomaterials: Imaging and rapid precise prototyping technology for custom made scaffolds Appel à propositions FP7-NMP-2013-EU-China Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI DI TRIESTE Contribution de l’UE € 486 600,00 Adresse VIA BONOMEA 265 34136 Trieste Italie Voir sur la carte Région Nord-Est Friuli-Venezia Giulia Trieste Type d’activité Higher or Secondary Education Establishments Contact administratif Gabriele Rizzetto (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italie Contribution de l’UE € 353 310,00 Adresse VIA MOREGO 30 16163 Genova Voir sur la carte Région Nord-Ovest Liguria Genova Type d’activité Research Organisations Contact administratif Claudia Schiaffino (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITA DEGLI STUDI DI TRIESTE Italie Contribution de l’UE € 150 000,00 Adresse PIAZZALE EUROPA 1 34127 Trieste Voir sur la carte Région Nord-Est Friuli-Venezia Giulia Trieste Type d’activité Higher or Secondary Education Establishments Contact administratif Paolo Balsini (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée ECOLE NORMALE SUPERIEURE France Contribution de l’UE € 404 880,00 Adresse 45, RUE D'ULM 75230 Paris Voir sur la carte Région Ile-de-France Ile-de-France Paris Type d’activité Higher or Secondary Education Establishments Contact administratif Anne Cormier (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MAX IV Laboratory, Lund University Suède Contribution de l’UE € 404 998,00 Adresse Paradisgatan 5c 22100 LUND Voir sur la carte Région Södra Sverige Sydsverige Skåne län Type d’activité Higher or Secondary Education Establishments Contact administratif Jens Schouenborg (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée