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Brain Imaging Return to Health

Objective

Extended lifespan is a new and permanent feature of human life globally. The demographic for population growth of persons over 60 years is predicted to expand by 70% and 400% respectively in developed and less developed regions during the coming decades. Ageing, is accompanied by cognitive decline and greater risk of depression and anxiety. Major drug companies have recently cutback significantly on development of drugs against brain disorders due to lack of new avenues of research. Thus the responsibility falls on academic labs to make breakthroughs to improve brain health.
This consortium gathers experts on molecular mechanisms of age-associated pathologies including depressive disorders and anxiety, and neurodegeneration. Specifically, they focus on identification of stress-regulated molecules provoking neuronal death and hindering neurogenesis, and monitoring the consequences of these processes in human brain.
The groups combine biological and medical imaging techniques with behavioral studies and proteomics to define molecular mechanisms of ageing and neurogenesis. Using biotechnology, they will create new tools to isolate neurogenic cells from aged brain, thus aiding research strategies an early stage. Four leading imaging infrastructures from across Europe selected from the ESFRI Eurobioimaging Proof-of Concept list have been selected as partners to facilitate this training and research program. Confocal and high-content imaging is used to define ageing pathways, proteomics and genomics to visualize effectors of pathological ageing, transgenic mice to study neurogenesis and MRI/MRS to identify and localize new depression-related parameters in select patient populations. This multi-faceted approach aims to (i) identify druggable targets and identify reagents to interfere with pathways contributing to depression and anxiety, and (ii) produce novel tools to image depression-associated events in brain, facilitating earlier diagnosis and intervention.

Call for proposal

FP7-PEOPLE-2013-ITN
See other projects for this call

Coordinator

ABO AKADEMI
Address
Domkyrkotorget 3
20500 Abo
Finland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 113 376,44
Administrative Contact
Siv Holmgren (Ms.)

Participants (9)

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 731 116,88
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Deirdre Savage (Ms.)
ITA-SUOMEN YLIOPISTO

Participation ended

Finland
EU contribution
€ 164 779,01
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hannele Juvaste (Dr.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 818 275,48
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marianne Olsson (Prof.)
LEIBNIZ-INSTITUT FUER NEUROBIOLOGIE
Germany
EU contribution
€ 201 800,72
Address
Brenneckestrasse 6
39118 Magdeburg
Activity type
Research Organisations
Administrative Contact
Thekla Thiel (Ms.)
IMMUNOVIA AB
Sweden
EU contribution
€ 259 925,16
Address
Scheelevagen 2 Medicon Village
223 81 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Carl Borrebaeck (Prof.)
ADVANCED PRACTICAL DIAGNOSTICS
Belgium
EU contribution
€ 230 340
Address
Raadsherenstraat 3
2300 Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Aye Mu Myint (Dr.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 307 056,64
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
BGI EUROPE INSTITUTE FOND

Participation ended

Denmark
EU contribution
€ 63 239,88
Address
Ole Maaloes Vej 3
2200 Kobenhavn N
Activity type
Other
Administrative Contact
Jue Wang (Mrs.)
TURUN YLIOPISTO
Finland
EU contribution
€ 324 399,79
Address
Yliopistonmaki
20014 Turku
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mari Riipinen (Dr.)