Objectif
Anthrax, caused by the spore forming bacterium Bacillus anthracis, is a disease of animals which can infect humans either directly through contact with infected animals or indirectly as a consequence of bioterrorism. In regions of the world such as Eastern Europe and Central Asia the pathogen still constitutes a significant threat to human and animal health. A lack of effective veterinary facilities, access to vaccines and the burial of untreated infected animals has resulted in the contamination of large areas due to the ability of the spores to survive in soil for many years. Given that the bacteria is non-contagious its elimination from contaminated soil and surfaces would have a major impact on disease incidence. We are seeking to to develop an approach which is specific for B.anthracis and will have minimal impact on the environment. Following preliminary field trails on animal burial sites in Turkey we have developed a technique whch triggers the conversion (germination) of B.anthracis spores into bacteriophage (phage) susceptible vegetative bacteria. Phages are natural preditors of bacteria, are species specific and found in close proximity to their prey. We hypothesize that a combination of germinants and B.anthracis specific phages will be an effective and ecologically friends means of reducing spore numbers. Indeed in laboratory studies we have demonstrated the feasibility of this approach. Additional phages have been isolated from burial sites in Georgia and Turkey and will be evaluated as part of this study. While there are a number of funded phage based anthrax decon projects in the region their is as yet no dedicated scientific network to facilitate the sharing of best practices and to link researchers in neighbouring countries facing similar problems. It is our intention to link these projects together in a manner which maximises the current investment and will deliver an environmentally friendly decontamination system.
Champ scientifique
Appel à propositions
FP7-PEOPLE-2013-IRSES
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Régime de financement
MC-IRSES - International research staff exchange scheme (IRSES)Coordinateur
CF24 0DE Cardiff
Royaume-Uni