Final Report Summary - F-TRACT (Functional Brain Tractography)
Human behaviour and cognition are linked to brain dynamics, which complexity starts to being reproduced by whole brain models in silico. These models are in desperate need of experimental data in human documenting spatial and temporal properties of large-scale connectivity that would allow to finesse and validate them. The only type of data for this purpose are the electrophysiological responses recorded during direct electrical stimulations (DES) of cortical regions performed in patients suffering from focal drug-resistant epilepsy who are explored using intracranial electrodes.
In the F-TRACT project, we have created an international clinical consortium, composed of 23 epilepsy surgery centres, to gather these rare data and have developed the largest DES database by including more than 1100 patient data. We have published the functional tractography F-TRACT atlas, which provides new information on the directionality, latency and velocity of neural signals along the large fiber tracts of the human brain. Beyond developing this new atlas, we have developed a suite of software solutions including the methodological innovations required by project's scientific objectives, which can now be re-used for research in epilepsy surgery. Both the atlas and softwares are publicly accessible from the website of the project (f-tract.eu).
Knowledge and methodological transfer has already been initiated with the European Flagship Human Brain Project, to achieve re-usability of the outputs of F-TRACT by the neuroscientific community at a larger scale in a multimodal context.
In the F-TRACT project, we have created an international clinical consortium, composed of 23 epilepsy surgery centres, to gather these rare data and have developed the largest DES database by including more than 1100 patient data. We have published the functional tractography F-TRACT atlas, which provides new information on the directionality, latency and velocity of neural signals along the large fiber tracts of the human brain. Beyond developing this new atlas, we have developed a suite of software solutions including the methodological innovations required by project's scientific objectives, which can now be re-used for research in epilepsy surgery. Both the atlas and softwares are publicly accessible from the website of the project (f-tract.eu).
Knowledge and methodological transfer has already been initiated with the European Flagship Human Brain Project, to achieve re-usability of the outputs of F-TRACT by the neuroscientific community at a larger scale in a multimodal context.