Objective
Dynamic signalling networks in Diabetic Nephropathy (DN) – New avenues to a personalized therapy.-
We have developed an exquisite experimental platform that facilitates the systematic unravelling of the signalling
networks leading to (1) the initiation, (2) the progression and (3) the potential regeneration of podocytes in
DN, paving the way to novel therapeutic strategies:
(1) DN initiation: Identification of signalling cascades leading to microalbuminuria: Molecular
By combining transgenic Drosophila lines carrying secreted fluorescent proteins to monitor the barrier function
in vivo with a genome-wide siRNA screen we will establish a unique system to directly identify gene
networks contributing to microalbuminuria.
(2a) DN progression: Molecular fingerprinting of podocyte degeneration: Based on a transgenic
fluorescent mouse model, we have pioneered a highly efficient podocyte purification method from type1 and
type 2 diabetic mice allowing us to develop a precise molecular genetic, quantitative proteomic and micro
RNA fingerprint from freshly isolated podocytes from diabetic and non-diabetic mice.
(2b) DN progression: We established a proteomic approach to measure site-specific phosphorylation dynamics in
primary podocyte cultures originating from transgenic mice that are TORC1 deficient, TORC2 deficient or
TORC1 hyperactive (TSC1 KO) solely in the podocytes.
(3) Potential role of podocyte regeneration in DN: Finally, to target mechanisms that could potentially
reverse the disease process (by repopulating lost podocytes), we invented a strategy to quantitatively monitor
podocyte turnover from different stem cell niches allowing us to precisely assess and potentially
manipulating the capacity of podocyte regeneration in DN.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes diabetic nephropathy
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2013-CoG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
20251 Hamburg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.