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SUpeR REsolution Adaptive LIght Sheet Microscopy for high resolution volumetric imaging in turbid specimen

Obiettivo

Rapid high contrast imaging in combination with low light exposure makes light sheet microscopy particularly attractive for studying the three-dimensional development of biological specimens. Currently however, the highest resolution of light sheet microscopy can only be achieved with relatively transparent samples. To study more advanced stages of development, of particular interest in brain imaging, scattering and aberrations pose a significant obstacle to achieve super-resolution or even diffraction limited resolution. Adaptive optics can correct aberrations in situ, yet inhomogeneities in the sample can severely restrict the usable field-of-view. Here we propose the use of structured illumination with variable periodicity to reclaim the resolution for a wide field-of-view. This Marie Curie Fellowship will thus enable super-resolution light sheet imaging deep within turbid biological tissue.

Campo scientifico (EuroSciVoc)

Argomento(i)

Invito a presentare proposte

FP7-PEOPLE-2013-IEF
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Meccanismo di finanziamento

MC-IEF - Intra-European Fellowships (IEF)

Coordinatore

UNIVERSIDAD CARLOS III DE MADRID
Contributo UE
€ 173 370,60
Indirizzo
CALLE MADRID 126
28903 Getafe (Madrid)
Spagna
Regione
Comunidad de Madrid Comunidad de Madrid Madrid
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
Nessun dato