Obiettivo We will investigate the role of the circadian clock in energy balance, metabolism and lifespan of C. elegans.The evolution of life on Earth has been dominated by the influence of the daily rhythms imposed by its rotational movement. As a consequence, endogenous circadian clocks are present in organisms from all phyla, helping them to anticipate the daily cycles in their environment. This endogenous clock gets information from external cues (zeitgebers) in order to synchronise internal timing to the 24 h day. Circadian clocks regulate processes from gene expression to behaviour, resulting in rhythms in metabolite levels and food intake. The disruption of circadian rhythms has been linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. As obesity becomes epidemic in industrialized societies in parallel with a well-documented disruption of our circadian rhythms, the relationship between them becomes highly relevant. We propose to investigate this problem using the nematode C. elegans, an emergent model for the study of circadian rhythms and already established for metabolic research. Campo scientifico medical and health sciencesclinical medicinepsychiatrysleep disordersmedical and health sciencesclinical medicineoncologymedical and health scienceshealth sciencesnutritionobesity Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2013-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Invito a presentare proposte FP7-PEOPLE-2013-IEF Vedi altri progetti per questo bando Meccanismo di finanziamento MC-IEF - Intra-European Fellowships (IEF) Coordinatore UNIVERSIDAD PABLO DE OLAVIDE Contributo UE € 223 002,20 Indirizzo CARRETERA DE UTRERA KM 1 41013 Sevilla Spagna Mostra sulla mappa Regione Sur Andalucía Sevilla Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Marta Mercado (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
