Objective
The strategic directions of multidisciplinary research at the Institute of Oceanology of the Polish Academy of Sciences include genetics and molecular biology of marine organisms, fields of research where progress increasingly depends on expertise in computational biology. This project will allow making the first step in introducing this much-needed expertise in the Institute and indeed in the region, which we hope will benefit several projects at the Institute (molecular systematics of marine invertebrate s, population genetics of fish and molluscs, marine microbiology). However, considering the short timeline, the utility of tools developed during the project will first be tested on a dataset of Hepatitis C Virus sequences obtained from an epidemic with kn own infection history. These data allow constructing a true phylogenetic tree with extensive temporal information, as the times for both the external nodes and crucial internal nodes are known. HCV displays one the highest rates of evolution detected in an y life form (reaching 10-2 substitutions/site/year. Moreover, extreme heterogeneity of substitution rate is observed in some of the regions of HCV genome. The project will concentrate on resolving the following issues:
(1) the level of heterogeneity of the rate of substitution among sites,
(2) the use of complex models (for example, models which allow multiple substitution matrices) for possibly better description of the data,
(3) the effects of the presence of positive selection on the molecular clock,
(4) the nature of amino acid substitutions that occur, especially in the context of the quasispecies hypothesis and the possibility of multiple infections. By analysing sequences coming from a major human pathogen, we hope to provide insight into the molecular biology of HCV and other RNA viruses, relevant not only for molecular evolution, but also for molecular medicine, molecular epidemiology and forensics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- natural sciences mathematics applied mathematics statistics and probability bayesian statistics
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences molecular biology molecular evolution
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
SOPOT
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.