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Dynamic hormone diagnostics

Objective

We propose to revolutionize current endocrine diagnostics by replacing conventional, time-consuming single-analyte hormone assays with ambulatory dynamic endocrine diagnostics. Disorders of the adrenal and pituitary endocrine systems are not only accompanied by changes in absolute hormone levels, but also secretion patterns. The rapid circadian (24 hour) and ultradian (< 24 hour) cycling of hormone levels poses diagnostic challenges since random measurements do not always detect abnormalities. Furthermore, monitoring of treatment of endocrine diseases are often severely limited by lack of multiple measurements at different time points, which is impractical in an out-patient setting.

To overcome these hurdles academic and commercial partners propose to:

• Develop a novel microdialysate sampling and analysis system for adrenal and pituitary hormonome profiling

• Validate the method in healthy vs. six populations with endocrine disorders

• Promote the system for demonstration in routine clinical practice by dissemination of results to relevant European stakeholders

The portable fraction collector for subcutaneous microdialysate combined with state-or-the-art ultrasensitive assays by liquid chromatography tandem mass spectroscopy (LCMS/MS) and multiplex proximity extension assays (Proseek), will allow collection of 10 minute fractions for up to 72 hours while the person tends to daily life activities. LCMSMS and Proseek assays can generate a timeline of “hormonomes” covering the 24 hour cycle without losing sensitivity and specificity, producing not only hormone levels, but also secretion patterns for diagnostics and monitoring purposes.

ULTRADIAN will deliver an ambulatory diagnostic system with unprecedented sensitivity and specificity for simplified diagnostics and monitoring of endocrine conditions, economisation of health care, and new products and markets for the European diagnostic sector.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy

Call for proposal

H2020-PHC-2014-two-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITETET I BERGEN
Address
Museplassen 1
5020 Bergen
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 002 047

Participants (6)

UNIVERSITY OF BRISTOL
United Kingdom
EU contribution
€ 1 221 521
Address
Beacon House Queens Road
BS8 1QU Bristol
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 938 307
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Navinci Diagnostics AB

Participation ended

Sweden
EU contribution
€ 0
Address
Chemistry Bmc - Box 599
751 24 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DESIGNWORKS WINDSOR LTD
United Kingdom
EU contribution
€ 437 500
Address
Unit 2 The Windsor Business Centre, Vansittart Estate
SL4 1SP Windsor
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PERIFEREIAKO GENIKO NOSOKOMEIO ATHINON EVAGGELISMOS
Greece
EU contribution
€ 713 281
Address
Ypsilantou 45-47
10676 Athina
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
OLINK PROTEOMICS AB
Sweden
EU contribution
€ 686 725
Address
Uppsala Science Park
751 83 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)