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Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time

Deliverables

Operational project specific MDS-RIGHT website

Operational project specific MDS-RIGHT website

Discussion platforms and a common website for stakeholder interaction

Discussion platforms and a common website for stakeholder interaction

Yearly updates of MDS website

Yearly updates of MDS website

Report of two meetings on state-of-the-art in the field of MDS

Report of two meetings on state-of-the-art in the field of MDS

Final dataset incorporating data generated from WP2, WP3 & WP4

Final dataset incorporating data generated from WP2, WP3 & WP4

Periodic report on mutational sequencing and epigenetic profiling in various cohorts

Reports on mutational sequencing and epigenetic profiling in various cohorts

Report of ethical, legal, and socio-economical aspects of the elderly low risk MDS population

Report of ethical, legal, and socio-economical aspects of the elderly low risk MDS population

Completed catalogue of all MDS caregiver cooperative groups, patient support groups and existing documents

Completed catalogue of all MDS caregiver cooperative groups, patient support groups and existing documents

Report on new COS including patient-reported, disease-specific outcomes

Report on new COS including patient-reported, disease-specific outcomes

Validation of a MDS-specific HRQoL questionnaire (QUALMS-1)

Validation of a MDS-specific HRQoL questionnaire (QUALMS-1)

Periodic report on immunophenotyping in various cohorts

Periodic report on immunophenotyping in various cohorts

Approved European and International guidelines uploaded at new ELN-linked website

Approved European and International guidelines uploaded at new ELN-linked website

Periodic report on bioinformatic integration of data

Periodic report on bioinformatic integration of data

Report describing prognostic impact of newly defined individual genetic defects on response to the existing HCI

Report describing prognostic impact of newly defined individual genetic defects on response to the existing HCI

Scientific, Clinical and Ethics Advisory Board

Appointment of Scientific, Clinical and Ethics Advisory Board

Promotion of educational and scientific meetings, pocket cards, posters, flyers, exhibition booth for meetings

Promotion of educational and scientific meetings, pocket cards, posters, flyers, exhibition booth for meetings

Report of early treatment response indicators supporting a targeted use of existing HCI

Report of early treatment response indicators supporting a targeted use of existing HCI

Searching for OpenAIRE data...

Publications

Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes

Author(s): Louise de Swart, Chloé Reiniers, Timothy Bagguley, Corine van Marrewijk, David Bowen, Eva Hellström-Lindberg, Aurelia Tatic, Argiris Symeonidis, Gerwin Huls, Jaroslav Cermak, Arjan A. van de Loosdrecht, Hege Garelius, Dominic Culligan, Mac Macheta, Michail Spanoudakis, Panagiotis Panagiotidis, Marta Krejci, Nicole Blijlevens, Saskia Langemeijer, Jackie Droste, Dorine W. Swinkels, Alex Smith, The
Published in: Haematologica, Issue 103/1, 2017, Page(s) 69-79, ISSN 0390-6078
DOI: 10.3324/haematol.2017.171884

GLM-based optimization of NGS data analysis: A case study of Roche 454, Ion Torrent PGM and Illumina NextSeq sequencing data

Author(s): Sarah Sandmann, Aniek O. de Graaf, Bert A. van der Reijden, Joop H. Jansen, Martin Dugas
Published in: PLOS ONE, Issue 12/2, 2017, Page(s) e0171983, ISSN 1932-6203
DOI: 10.1371/journal.pone.0171983

BBCAnalyzer: a visual approach to facilitate variant calling

Author(s): Sarah Sandmann, Aniek O. de Graaf, Martin Dugas
Published in: BMC Bioinformatics, Issue 18/1, 2017, Page(s) 133: 1-6, ISSN 1471-2105
DOI: 10.1186/s12859-017-1549-4

Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel

Author(s): Theo de Witte, David Bowen, Marie Robin, Luca Malcovati, Dietger Niederwieser, Ibrahim Yakoub-Agha, Ghulam J. Mufti, Pierre Fenaux, Guillermo Sanz, Rodrigo Martino, Emilio Paolo Alessandrino, Francesco Onida, Argiris Symeonidis, Jakob Passweg, Guido Kobbe, Arnold Ganser, Uwe Platzbecker, Jürgen Finke, Michel van Gelder, Arjan A. van de Loosdrecht, Per Ljungman, Reinhard Stauder, Liisa Volin, H. J
Published in: Blood, Issue 129/13, 2017, Page(s) 1753-1762, ISSN 0006-4971
DOI: 10.1182/blood-2016-06-724500

Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT

Author(s): Gerbrig Berger, Leonie I. Kroeze, Theresia N. Koorenhof-Scheele, Aniek O. de Graaf, Kenichi Yoshida, Hiroo Ueno, Yuichi Shiraishi, Satoru Miyano, Eva van den Berg, Hein Schepers, Bert A. van der Reijden, Seishi Ogawa, Edo Vellenga, Joop H. Jansen
Published in: Blood, Issue 131/16, 2018, Page(s) 1846-1857, ISSN 0006-4971
DOI: 10.1182/blood-2017-09-805879

Health-related quality of life in lower-risk MDS patients compared with age- and sex-matched reference populations: a European LeukemiaNet study

Author(s): Reinhard Stauder, Ge Yu, Karin A. Koinig, Tim Bagguley, Pierre Fenaux, Argiris Symeonidis, Guillermo Sanz, Jaroslav Cermak, Moshe Mittelman, Eva Hellström-Lindberg, Saskia Langemeijer, Mette Skov Holm, Krzysztof Mądry, Luca Malcovati, Aurelia Tatic, Ulrich Germing, Aleksandar Savic, Corine van Marrewijk, Agnès Guerci-Bresler, Elisa Luño, Jackie Droste, Fabio Efficace, Alex Smith, David Bowen,
Published in: Leukemia, Issue 32/6, 2018, Page(s) 1380-1392, ISSN 0887-6924
DOI: 10.1038/s41375-018-0089-x

Clonal evolution in myelodysplastic syndromes

Author(s): Pedro da Silva-Coelho, Leonie I. Kroeze, Kenichi Yoshida, Theresia N. Koorenhof-Scheele, Ruth Knops, Louis T. van de Locht, Aniek O. de Graaf, Marion Massop, Sarah Sandmann, Martin Dugas, Marian J. Stevens-Kroef, Jaroslav Cermak, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Theo de Witte, Nicole M. A. Blijlevens, Petra Muus, Gerwin Huls, Bert A. van der Reijden, Seishi Ogawa, Joo
Published in: Nature Communications, Issue 8, 2017, Page(s) 15099, ISSN 2041-1723
DOI: 10.1038/ncomms15099

Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data

Author(s): Sarah Sandmann, Aniek O. de Graaf, Mohsen Karimi, Bert A. van der Reijden, Eva Hellström-Lindberg, Joop H. Jansen, Martin Dugas
Published in: Scientific Reports, Issue 7, 2017, Page(s) 43169, ISSN 2045-2322
DOI: 10.1038/srep43169

VIPER: a web application for rapid expert review of variant calls

Author(s): Marius Wöste, Martin Dugas
Published in: Bioinformatics, Issue 34/11, 2018, Page(s) 1928-1929, ISSN 1367-4803
DOI: 10.1093/bioinformatics/bty022

Early platelet count kinetics has prognostic value in lower-risk myelodysplastic syndromes

Author(s): Raphael Itzykson, Simon Crouch, Erica Travaglino, Alex Smith, Argiris Symeonidis, Eva Hellström-Lindberg, Guillermo Sanz, Jaroslav Čermák, Reinhard Stauder, Chiara Elena, Ulrich Germing, Moshe Mittelman, Saskia Langemeijer, Krzysztof Mądry, Aurelia Tatic, Mette Skov Holm, Antonio Medina Almeida, Aleksandar Savic, Njetočka Gredelj Šimec, Elisa Luño, Dominic Culligan, Agnes Guerci-Bresler, Lu
Published in: Blood Advances, Issue 2/16, 2018, Page(s) 2079-2089, ISSN 2473-9529
DOI: 10.1182/bloodadvances.2018020495

Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome

Author(s): H. K. G. Garelius, W. T. Johnston, A. G. Smith, S. Park, L. de Swart, P. Fenaux, A. Symeonidis, G. Sanz, J. Čermák, R. Stauder, L. Malcovati, M. Mittelman, A. A. van de Loosdrecht, C. J. van Marrewijk, D. Bowen, S. Crouch, T. J. M. de Witte, E. Hellström-Lindberg
Published in: Journal of Internal Medicine, Issue 281/3, 2016, Page(s) 284-299, ISSN 0954-6820
DOI: 10.1111/joim.12579

appreci8: a pipeline for precise variant calling integrating 8 tools

Author(s): Sarah Sandmann, Mohsen Karimi, Aniek O de Graaf, Christian Rohde, Stefanie Göllner, Julian Varghese, Jan Ernsting, Gunilla Walldin, Bert A van der Reijden, Carsten Müller-Tidow, Luca Malcovati, Eva Hellström-Lindberg, Joop H Jansen, Martin Dugas
Published in: Bioinformatics, Issue 34/24, 2018, Page(s) 4205-4212, ISSN 1367-4803
DOI: 10.1093/bioinformatics/bty518

ODM Data Analysis—A tool for the automatic validation, monitoring and generation of generic descriptive statistics of patient data

Author(s): Tobias Johannes Brix, Philipp Bruland, Saad Sarfraz, Jan Ernsting, Philipp Neuhaus, Michael Storck, Justin Doods, Sonja Ständer, Martin Dugas
Published in: PLOS ONE, Issue 13/6, 2018, Page(s) e0199242, ISSN 1932-6203
DOI: 10.1371/journal.pone.0199242

Impact of treatment with iron chelation therapy in patients with lower-risk myelodysplastic syndromes participating in the European MDS registry

Author(s): Marlijn Hoeks, Ge Yu, Saskia Langemeijer, Simon Crouch, Louise de Swart, Pierre Fenaux, Argiris Symeonidis, Jaroslav Čermák, Eva Hellström-Lindberg, Guillermo Sanz, Reinhard Stauder, Mette Skov Holm, Moshe Mittelman, Krzysztof Mądry, Luca Malcovati, Aurelia Tatic, Antonio Medina Almeida, Ulrich Germing, Aleksandar Savic, Njetočka Gredelj Šimec, Dominic Culligan, Raphael Itzykson, Agnes Guerc
Published in: Haematologica, Issue Haematologica 2019 Jul 5; Epub ahead of print, 2019, Page(s) haematol.2018.212332, ISSN 0390-6078
DOI: 10.3324/haematol.2018.212332

Impact of red blood cell transfusion dose density on progression-free survival in lower-risk myelodysplastic syndromes patients

Author(s): Louise de Swart, Simon Crouch, Marlijn Hoeks, Alex Smith, Saskia Langemeijer, Pierre Fenaux, Argiris Symeonidis, Jaroslav Čermák, Eva Hellström-Lindberg, Reinhard Stauder, Guillermo Sanz, Moshe Mittelman, Mette Skov Holm, Luca Malcovati, Krzysztof Mądry, Ulrich Germing, Aurelia Tatic, Aleksandar Savic, Antonio Medina Almeida, Njetočka Gredelj-Šimec, Agnes Guerci-Bresler, Odile Beyne-Rauzy, D
Published in: Haematologica, Issue Haematologica 2019 Jun 6; Epub ahead of print, 2019, Page(s) haematol.2018.212217, ISSN 0390-6078
DOI: 10.3324/haematol.2018.212217

Computational analysis of flow cytometry data in hematological malignancies


Published in: ISSN 1040-8746
DOI: 10.1097/cco.0000000000000607

Association of anemia with health-related quality of life and survival: a large population-based cohort study

Author(s): Hanneke J.C.M. Wouters, Melanie M. van der Klauw, Theo de Witte, Reinhard Stauder, Dorine W. Swinkels, Bruce H.R. Wolffenbuttel, Gerwin Huls
Published in: Haematologica, Issue 104/3, 2019, Page(s) 468-476, ISSN 0390-6078
DOI: 10.3324/haematol.2018.195552

Multidisciplinary care in the hematology clinic: Implementation of geriatric oncology

Author(s): Valentin Goede, Reinhard Stauder
Published in: Journal of Geriatric Oncology, Issue 10/3, 2019, Page(s) 497-503, ISSN 1879-4068
DOI: 10.1016/j.jgo.2018.09.003

Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals

Author(s): Isabelle A. van Zeventer, Aniek O. de Graaf, Hanneke JCM Wouters, Bert A. Van der Reijden, Melanie van der Klauw, Theo M de Witte, Marianne A. Jonker, Luca Malcovati, Joop H Jansen, Geert Huls
Published in: Blood, Issue 135(14), 2020, Page(s) 1161-1170, ISSN 0006-4971
DOI: 10.1182/blood.2019004362

AMLVaran: a software approach to implement variant analysis of targeted NGS sequencing data in an oncological care setting

Author(s): Christian Wünsch, Henrik Banck, Carsten Müller-Tidow, Martin Dugas
Published in: BMC Medical Genomics, Issue 13/1, 2020, ISSN 1755-8794
DOI: 10.1186/s12920-020-0668-3

Myelodysplastic syndromes: moving towards personalized management

Author(s): Eva Hellström-Lindberg, Magnus Tobiasson, Peter Greenberg
Published in: Haematologica, Issue 105/7, 2020, Page(s) 1765-1779, ISSN 0390-6078
DOI: 10.3324/haematol.2020.248955

Development of a core outcome set for myelodysplastic syndromes – a Delphi study from the EUMDS Registry Group

Author(s): Ursula Rochau, Igor Stojkov, Annette Conrads‐Frank, Helena H. Borba, Karin A. Koinig, Marjan Arvandi, Corine Marrewijk, Hege Garelius, Ulrich Germing, Argiris Symeonidis, Guillermo F. Sanz, Pierre Fenaux, Theo Witte, Fabio Efficace, Uwe Siebert, Reinhard Stauder
Published in: British Journal of Haematology, Issue 2020 May 14. [Epub ahead of print], 2020, ISSN 0007-1048
DOI: 10.1111/bjh.16654

Clinical and Lab Parameters may rule out and assist in the Diagnosis of MDS

Author(s): Oster HS, Crouch S, Smith A, Yu G, Abu Shrkihe B, Baruch S, Kolomansky A, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Madry K, Guerci-Bresler A, Culligan D, Sanhes L, Mills J, Kotsianidis I, van Marrewijk C, Bowen D, de Witte T and Mittelman M
Published in: Leukemia, Issue (under peer review), 2020, ISSN 0887-6924

Novel dynamic outcome indicators and clinical endpoints in myelodysplastic syndromes; the EUMDS Registry and MDS-RIGHT project perspective.

Author(s): de Witte T, Malcovati L, Fenaux P, Bowen D, Symeonidis A, Mittelman M, Stauder R, Sanz G, Čermák J, Langemeijer S, Hellström-Lindberg E, Germing U, Holm MS, Mądry K, Tatic A, Almeida AM, Savic A, Mandac Rogulj I, Itzykson R, Hoeks M, Garelius HG, Culligan D, Kotsianidis I, Ades L, van de Loosdrecht AA, van Marrewijk C, Yu G, Crouch S, Smith A.
Published in: Haematologica, Issue (under peer-review), 2020, ISSN 0390-6078

Impact of Treatment with Iron Chelation Therapy in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Author(s): Hoeks M, Yu G, Langemeijer S, Crouch S, de Swart L, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Skov-Holm M, Mittelman M, Madry K, Malcovati L, Tatic A, Almeida AM, Germing U, Savic A, Gredelj-Šimec N, Culligan D, Itzykson R, Guerci-Bresler A, Slama B, van Marrewijk C, Droste J, van Kraaij M, Bowen DT, de Witte TM, Smith A.
Published in: Blood, Issue 130, S1, 2017, Page(s) "#425"

Identifying Predictors for Low Health-Related Quality of Life in Patients with Myelodysplastic Syndromes – Research Protocol

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Koinig KA, Arvandi M, Efficace F, Stauder R, Siebert U
Published in: Annual Conference of the German Network for Evidence-based Medicine, 2018

Impact of Treatment with Iron Chelation Therapy in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Author(s): Hoeks M, Yu G, Langemeijer S, Crouch S, de Swart L, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Skov-Holm M, Mittelman M, Madry K, Malcovati L, Tatic A, Almeida AM, Germing U, Savic A, Gredelj-Šimec N, Culligan D, Itzykson R, Guerci-Bresler A, Slama B, van Marrewijk C, Droste J, van Kraaij M, Bowen DT, de Witte TM, Smith A.
Published in: Dutch Hematology Congress 2018, published in: Nederlands Tijdshrift voor Geneeskunde, 2018

Impact of anemia on health-related quality of life depends on age and etiology

Author(s): Wouters HJCM, Van der Klauw MM, de Witte T, Stauder R, Swinkels DW, Wolffenbuttel BHR, Huls G
Published in: Dutch Hematology Congress 2018 (Nederlands Tijdshrift voor Geneeskunde), 2018

Impact of Red Blood Cell Transfusion Intensity on Progression-Free Survival in Lower-Risk MDS Patients Included in the European Leukemianet MDS Registry

Author(s): de Swart L, Crouch S, Hoeks M, Smith A, Langemeijer S, Fenaux P, Symeonidis A, Cermak J, Stauder R, Mittelman M, Sanz G, Hellstrom-Lindberg E, Malcovati L, Holm MS, Germing U, Madry K, Almeida AM, Tatic A, Savic A, Gredelj-Šimec N, Guerci Bresler A, Culligan D, Itzykson R, Beyne-Rauzy O, Park S, van Marrewijk C, Blijlevens NMA Bowen DT, de Witte TM.
Published in: Blood, Issue 130, S1, 2017, Page(s) "#1690"

Identifying Multinational Cost Data: A Methodological Review and Case Study

Author(s): Thomas Patton, Chu-Mei Hung, Martin Henriksson, Mirjana Huić, Ana Patrícia Marques, Sibylle Puntscher, Đurđa Vukićević, Matteo Ruggeri, Andrea Manca
Published in: EUHEA conference 2018, Maastricht, Issue July 2018, 2018

Appreci8: a pipeline for precise variant calling integrating 8 tools

Author(s): Sandmann S, de Graaf AO, Karimi M, van der Reijden BA, Hellström-Lindberg E, Jansen JH, Dugas M
Published in: Haematologica, Issue 102,S2, Jun 26, 2017

Deriving Core Outcomes for Myelodysplastic Syndromes – Health Professionals’ Perspective

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Koinig KA, Arvandi M, Efficace F, Stauder R, Siebert U
Published in: Annual Conference of the German Network for Evidence-based Medicine, 2018

Systematic Overview of Patient-Reported Outcomes for Myelodysplastic Syndromes

Author(s): Stojkov I, Rochau U, Conrads-Frank A, Borba HH, Koinig KA, Arvandi M, Efficace F, Stauder R, Siebert U.
Published in: 17th Biennial European Conference of the Society for Medical Decision Making, 2018

Developing a Core Outcomes for Myelodysplastic Syndromes – The MDS-RIGHT Health Professional Delphi Survey

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Koinig K.A., Arvandi M, Symeonidis A, Sanz G, Fenaux P, Bowen D, Mittelmann M, Garelius H, Germing U, van Marrewijk C , Cermak J, Hellström-Lindberg E, Smith A, de Witte T, Efficace F, Siebert U, Stauder R.
Published in: Haematologica, Issue 103, S1, 2018

Prognostic Value of Early Drop in Platelets in Lower-Risk MDS. A Sub-Study from the European Leukemianet Lower-Risk MDS (EUMDS) Registry

Author(s): Itzykson R, Smith A, Fenaux P, Symeonidis A, Mittelman M, Stauder R, Sanz G, Cermak J, Hellstrom-Lindberg E, Malcovati L, Langemeijer S, Germing U, Madry KM, Holm MS, Tatic A, Almeida AM, Savic A, Gredelj-Šimec N, Bowen D, de Witte T.
Published in: Leukemia Research, Issue 55, S1, 2017, Page(s) "#19, S10-11"

Impact of Red Blood Cell Transfusion Rate, Adjusted by Therapeutic interventions, on Progression-Free Survival in Lower-Risk MDS Patients within the European LeukemiaNet MDS Registry

Author(s): de Swart L, Hoeks M, Crouch S, Smith A, Langemeijer S, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Stauder R, Sanz G, Mittelman M, Holm MS, Malcovati L, Madry K, Germing U, Savic A, Almeida AM, Guerci Bresler A, Itzykson R, Beyne-Rauzy O, Culligan D, van Marrewijk C, Blijlevens NMA Bowen DT, de Witte TM.
Published in: Haematologica, Issue 103, S1, 2018

Benchmarking Variant Calling Tools for NGS Data

Author(s): Sandmann S, de Graaf AO, Karimi M, van der Reijden BA, Hellström-Lindberg E, Jansen JH, Dugas M
Published in: F1000Research, Issue 6(ISCB Comm J):1353, 2017

Health-Related Quality of Life Is Substantially Impaired in Lower-Risk MDS When Compared with Reference Populations and Significantly Affects Overall Survival

Author(s): Stauder R, Yu G, Koinig K, Fenaux P, Symeonidis A, Sanz G, Cermak J, Mittelman M, Hellstrom-Lindberg E, Langemeijer S, Holm MS, Madry K, Malcovati L, Tatic A, Germing U, Savic A, Efficace F, Smith A, Bowen D, de Witte T.
Published in: Leukemia Research, Issue 55, S1, 2017, Page(s) "#22, S12"

Impact of Red Blood Cell Transfusions on Survival in Lower-Risk MDS Patients Included in the European Leukemianet MDS (EUMDS) Registry

Author(s): de Swart L, Crouch S, Smith A, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Malcovati L, Germing U, Langemeijer S, Holm MS, Mittelman M, Mądry K, Almeida A, Savic A, Itzykson R, Bowen D, de Witte T.
Published in: Leukemia Research, Issue 55, S1, 2017, Page(s) "#280, S160-161"

A Prognostic Classifier Based on Early Platelet Drop in Lower-Risk MDS a Study from the European Leukemianet Lower-Risk MDS (EUMDS) Registry

Author(s): Itzykson R, Crouch S, Smith A, Symeonidis A, Hellstrom-Lindberg E, Sanz G, Cermak J, Stauder R, Malcovati L, Germing U, Mittelman M, Langemeijer S, Madry K, Tatic A, Holm MS, Almeida AM, Savic A, Gredelj-Šimec N, Luño Fernandez E, Culligan D, Guerci Bresler A, van Marrewijk C, Bowen DT, de Witte TM, Fenaux P.
Published in: Blood, Issue 130, S1, 2017, Page(s) "#158"

Detecting small structural variants in amplicon-based NGS data - an evaluation of ten algorithms

Author(s): Marius Wöste, Sarah Sandmann, Aniek de Graaf, Bert van der Reijden, Joop Jansen, and Martin Dugas
Published in: ISMB abstrats, 2017

Developing a Core Outcome Set for Myelodysplastic Syndromes - an International Delphi Survey

Author(s): Stojkov I, Rochau U, Conrads-Frank A, Koinig K.A., Arvandi M, Symeonidis A, Sanz G, Fenaux P, Bowen D, Mittelmann M, Garelius H, Germing U, van Marrewijk C , Cermak J, Hellström-Lindberg E, Smith A, de Witte T, Efficace F, Stauder R, Siebert U.
Published in: 40th Annual North American Meeting of the Society for Medical Decision Making, Issue october 2018, 2018

Impact van behandeling met ijzerchelatietherapie op patiënten met een laag-risico myelodysplastisch syndroom die deelnemen aan de Europese MDS registratie

Author(s): Hoeks M, Yu G, Langemeijer S, Crouch S, de Swart L, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Skov-Holm M, Mittelman M, Madry K, Malcovati L, Tatic A, Almeida AM, Germing U, Savic A, Gredelj-Šimec N, Culligan D, Itzykson R, Guerci-Bresler A, Slama B, van Marrewijk C, Droste J, van Kraaij M, Bowen DT, de Witte TM, Smith A.
Published in: NVB-TRIP, 2018

Systematic Review of Quality of Life Measurement Instruments and Response Criteria among Patients with Myelodysplastic Syndromes

Author(s): Stojkov I, Rochau U, Borba HH, Jevdjevic M, Koinig KA, Arvandi M, Efficace F, Stauder R, Siebert U.
Published in: ISPOR 19th Annual European Congress; publised in: Value in Health, Issue 19/7, 2016, Page(s) A596, ISSN 1098-3015

Impact of Treatment with Iron Chelators in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Author(s): Saskia Langemeijer, Louise De Swart, Ge Yu, Alex Smith, Simon Crouch, Tom Johnston, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Eva Hellstrom-Lindberg, Guillermo Sanz, Reinhard Stauder, Luca Malcovati, Ulrich Germing, Mette Skov Holm, Moshe Mittelman, Krzysztof Madry, Aurelia Tatic, Antonio Almeida, Aleksandar Savic, Sophie Park, Odile Beyne-Rauzy, Raphaël Itzykson, Corine van Marrewijk,
Published in: Blood, Issue 128, 2016, Page(s) 3186

Comparison of 1690 MDS Patients from the European LeukemiaNet Registry and Reference Populations - Evidence for a Significant impairment in QoL in MDS and Definition of Predictors of Diminished QoL

Author(s): Reinhard Stauder , Ge Yu , Tim Bagguley , Pierre Fenaux , Argiris Symeonidis , Guillermo Sanz , Jaroslav Cermak , Moshe Mittelman , Eva Hellström-Lindberg , Saskia Langemeijer , Mette Skov Holm , Krzysztof Mądry , Luca Malcovati , Aurelia Tatic , Ulrich Germing , Aleksandar Savic , Corine van Marrewijk , Agnès Guerci-Bresler , Elisa Luño , Jackie Droste , Karin Koinig , Alex Smith , David Bowe
Published in: Hematologica, Issue Volume: 101 Pages: 16-17 Supplement: 1 Meeting Abstract: S13, 2016

Systematic Overview of Response Criteria among Patients with Myelodysplastic Syndromes

Author(s): I Stojkov, U Rochau, HH Borba, M Jevdjevic, K Koinig, M Arvandi, F Efficace, R Stauder, U Siebert
Published in: Society for Medical Decision Making, 38th Annual North American Meeting; published in Value in Health, Issue 19/7, 2016, Page(s) A596 (PSY119), ISSN 1098-3015

Elevated Labile Plasma Iron Levels (LPI) and Increased Oxidative Stress Are Associated with Red Blood Cell Transfusions in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) Subtitle: from the European Leukemianet MDS Registry

Author(s): Marlijn Hoeks, Saskia Langemeijer, Louise De Swart, Tim Bagguley, Corine van Marrewijk, David Bowen, Jaroslav Cermak, Eva Hellstrom-Lindberg, Aurelia Tatic, Argiris Symeonidis, Marian G.J. Van Kraaij, Panagiotis Panagiotidis, Hege Garelius, Dominic J Culligan, Marta Krejci, Jackie Droste, Alexandra Smith, Dorine W. Swinkels and Theo de Witte
Published in: Blood, Issue 128, 2016, Page(s) 4327

Evaluating and Optimizing Variant Calling: A Comparison of Roche 454, Ion Torrent PGM and Illumina NextSeq Sequencing Data

Author(s): Sarah Sandmann, Aniek de Graaf, Bert van der Reijden, Joop Jansen and Martin Dugas
Published in: F1000Research, 2015

Confident Variant Calling in NGS Data – A Mission Impossible?

Author(s): Sarah Sandmann, Aniek de Graaf, Bert van der Reijden, Joop Jansen and Martin Dugas
Published in: F1000Research, 2016

Elevated Labile Plasma Iron (LPI) Levels in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) Are Associated with Decreased Quality of Life and Reduced Survival

Author(s): Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellström-Lindberg E, Tatic A, Langemeijer S, Culligan DJ, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels DW, and de Witte TM
Published in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Issue 132, S1, 2018, Page(s) 4392

DTUrtle – an easily accessible Differential Transcript Usage analysis pipeline

Author(s): Tekath T, Dugas M
Published in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Issue 14-Aug, 2019, Page(s) 8-1434, ISSN 2046-1402

New prognostic indicators in MDS identified during the first 10 years of the EUropean LeukemiaNet MDS (EUMDS) Registry

Author(s): de Witte T, Fenaux P, Bowen D, Symeonidis A, Mittelman M, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Langemeijer S, Germing U, Holm MS, Mądry K, Tatic A, Almeida AM, Savic A, Gredelj Šimec N, Itzykson R, Culligan D, Kotsianidis I, Ades L, van de Loosdrecht AA, van Marrewijk C, Yu G, Crouch S, Malcovati L, Smith A, on behalf of the EUMDS Registry Participants
Published in: MDS-Foundation (15th) International symposium on MDS; published in: Leukemia Research, 2019

Can We Diagnose MDS without Bone Marrow Examination? a Proposed EUMDS-Based Non-Invasive Diagnostic Model

Author(s): Oster HS, Shrkihe BA, Crouch S, Smith A, Yu G, Carmi G, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Cermak J, Sanz G, Hellstrom-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Madry K, Tatic A, Almeida AM, Savic A, Gredelj-Šimec N, Guerci Bresler A, van Marrewijk C, Bowen DT, de Witte TMM, Mittelman M
Published in: American Society of Hematology 2017 (59th) Annual meeting; published in: Blood, Issue 130, S1, 2017, Page(s) 2975

Deriving Core Patient-Reported Outcomes in Patients with Myelodysplastic Syndromes - a Delphi Survey from the European-MDS Registry

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Koinig KA, Borba H, Arvandi M, Fenaux P, Symeonidis A, Bowen DT, Mittelman M, van Marrewijk C, de Witte T, Efficace F, Siebert U and Stauder R
Published in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Issue 132, S1, 2018, Page(s) 2295

Transfusie-afhankelijkheid is geassocieerd met de aanwezigheid van toxische ijzersoorten en slechtere overleving bij patiënten met een laag-risico myelodysplastisch syndroom

Author(s): Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellstrom-Lindberg E, Tatic A, Langemeijer S, Culligan D, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels D, de Witte T
Published in: Nederlandse Vereniging voor Bloedtransfusie - TRIP Symposium 2019; published in: unknown, 2019, Page(s) "#27"

I-CARE for MDS: Development of Guidelines-Based Indicators for Appropriate Care in Adult Patients with Myelodysplastic Syndromes

Author(s): Stojkov K, Silzle T, Stussi G, Schwappach D, Bernhard J, Bowen D, Čermák J, Dinmohamed A, Eeltink C, Eggmann S, Fenaux P, Germing U, Haschke M, Hellstrom-Lindberg E, Heger M, van de Loosdrecht AA, Passweg J, Pfeilstöcker M, Platzbecker U, Malcovati L, Almeida AM, Mittelman M, Morgenthaler C, Steensma D, Santini V, Stauder R, Symeonidis A, Schaer S, Maddox C, de Witte T, Bohlius J, Bonadies N
Published in: American Society of Hematology 2019 (61th) Annual meeting; published in: Blood, Issue 134, S1, 2019, Page(s) 4752

Transfusion dependancy is associated with presence of toxic iron species and inferior survival in patients with lower-risk myelodysplastic syndromes

Author(s): Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellstrom-Lindberg E, Tatic A, Langemeijer S, Culligan D, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels D, de Witte T
Published in: International Society of Blood Transfusion (29th) Regional Congress; published in: unknown, 2019

Clonal evolution in MDS

Author(s): Jansen J
Published in: European hematology Association 2017 (22nd) Congress; published in: EHA open access library, 2017

Consensus on a Core Outcome Set for Myelodysplastic syndromes

Author(s): Rochau U, Stojkov I, Conrads-Frank A, Borba H, Koining K, Arvandi M, van Marrewijk C, Garelius H, Germing U, Symeonidis A, Sanz G, Fenaux P, de Witte T, Efficace F, Siebert U, Stauder R.
Published in: MDS-Foundation (15th) International symposium on MDS; published in: Leukemia Research, 2019

Excess Mortality in Low-Risk MDS Can be Explained By MDS and AML Related Causes of Death

Author(s): Mądry K, Yu G, Lis K, Fenaux P, Bowen D, Symeonidis A, Mittelman M, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Guerci-Bresler A, Culligan D, Sanhes L, Mills J, Kotsianidis I, van Marrewijk C, Couch S, de Witte T, Smith A, on behalf of the EUMDS Registry Participants
Published in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Issue 132, S1, 2018, Page(s) 4385

Transfusion dependancy is associated with presence of toxic iron species and inferior survival in patients with lower-risk myelodysplastic syndromes

Author(s): Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellstrom-Lindberg E, Tatic A, Langemeijer S, Culligan D, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels D, de Witte T
Published in: European hematology Association 2019 (24th) Congress; published in: EHA open access library, Issue 15-Jun, 2019, Page(s) 267421; S838

"Appreci8R: an R package for calling variants the ""appreci8""-way"

Author(s): Sandmann S, Dugas M
Published in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Issue 12-Aug, 2019, Page(s) 8-1414, ISSN 2046-1402

Labile Plasma Iron (LPI) Is a Clinical Indicator of Overt Iron Overload in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) from the European Leukemianet MDS Registry

Author(s): de Swart L, Reiniers C, Bagguley T, Bowen D, Cermak J, Hellstrom-Lindberg E, Tatic A, Symeonidis A, Huls G, Panagiotidis P, Garelius H, Culligan D, Krejci M, van Marrewijk C, Droste J, Smith A, Swinkels DW, de Witte T
Published in: American Society of Hematology 2015 (57th) Annual meeting; published in: Blood, Issue 126/23, 2015, Page(s) 2865

Longitudinal Changes of Impairments in Health-Related Quality of Life in Lower-Risk MDS Patients: A European Leukemianet Study

Author(s): Stauder R, Yu G, Koinig KA, Culligan D, Fenaux P, Cermak J, Symeonidis A, Bernal T, Hellström-Lindberg E, Mittelman M, Langemeijer S, Holm MS, Mills J, Guerci-Bresler A, van Marrewijk C, Garelius H, Efficace F, Smith A, Bowen D, and de Witte TM
Published in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Issue 132, S1, 2018, Page(s) 3097

How to “appreci8” Variant Calling in NGS Data

Author(s): Sandmann S, Dugas M
Published in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Issue 20-Dec, 2019, Page(s) 8-2128, ISSN 2046-1402

A Web Application Could Help in MDS Diagnosis and Obviate the Bone Marrow Examination

Author(s): Oster H, Crouch S, Smith A, Yu G, Abu Shrkihe B, Shoham B, Kolomansky A, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Malcovati L, Germing U, Holm MS, Guerci- Bresler A, Culligan D, Laurence S, Mills J, Kotsianidis I, van Marrewijk C, Bowen D, de Witte T, Mittelman M.
Published in: MDS-Foundation (15th) International symposium on MDS; published in: Leukemia Research, 2019

Prognostic Impact of Transfusions Intensity on Survival and Development of Thrombocytopenia in Newly Diagnosed Lower-Risk MDS Patients Participating in the European Leukemianet EUMDS Registry

Author(s): de Swart L, Johnston T, Smith A, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Malcovati L, Germing U, Huls G, Holm MS, Mittelman M, Madry K, Tatic A, Almeida AM, Savic A, Park S, Beyne-Rauzy O, Itzykson R, van Marrewijk C, Bowen D, de Witte T
Published in: American Society of Hematology 2015 (57th) Annual meeting; published in: Blood, Issue 126/23, 2015, Page(s) 1677

Immunophenotypically Aberrant Stem Cells in Myelodysplastic Syndromes: A Biomarker for Leukemic Progression

Author(s): Margot F. Van Spronsen, Theresia M. Westers, Birgit I. Witte, Gert J. Ossenkoppele, Arjan A. Van de Loosdrecht
Published in: American Society of Hematology 2017 (59th) Annual meeting; published in: Blood, Issue 130, S1, 2017, Page(s) 4240

AMLVaran: Improvements in user-friendlyness of a human NGS variant assessment system

Author(s): Wünsch C, Dugas M
Published in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Issue 30-Jul, 2019, Page(s) 8-1232, ISSN 2046-1402

MDS Diagnosis: Many Patients May Not Require Bone Marrow Examination

Author(s): Oster HS, Crouch S, Smith A, Yu G, Abu Shrkihe B, Baruch S, Kolomansky A, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Cermak J, Sanz G, Hellström-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Madry K, Guerci-Bresler A, Culligan D, Sanhes L, Mills J, Kotsianidis I, van Marrewijk C, Bowen D, de Witte T and Mittelman M
Published in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Issue 132, S1, 2018, Page(s) 4357

The anemia-independant effect of Myelodysplastic Syndromes on Health-Related Quality of Life

Author(s): Wouters H, Conrads-Frank A, Koinig KA, Smith A, Yu G, de Witte T, Wolffenbuttel B, Huls G, Siebert U, Stauder R, van der Klauw M
Published in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Issue 6-dec, 2020, Page(s) 295150; S331

Assessing the Determinants of Health-Related Quality of Life in patients with Myelodysplastic Syndromes

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Arvandi M, Koinig KA, Schomaker M, Puntscher S, Schmid D, van Marrewijk C, Smith A, de Witte T, Siebert U, Stauder R
Published in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Issue 6-dec, 2020, Page(s) 294713; EP796

Impact of Erythropoietin Stimulation Agents and Red Blood Cell Transfusion on Health-related Quality of Life in Lower-risk Myelodysplastic Syndrome

Author(s): Garelius H, Smith A, Appleton S, Bowen D, Fenaux P, Symeonidis A, Mittelman M, Stauder R, Čermák J, Sanz G, Langemeijer S, Holm MS, Itzykson R, Culligan D, Heibl S, Mills J, Bernal T, Kotsianidis I, Ades L, Koinig K, van Marrewijk C, Crouch S, de Witte T, Hellström-Lindberg E
Published in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Issue 6-Dec, 2020, Page(s) 294733; EP816

Consensus set of Core Patient-Reported Outcomes for Myelodysplastic Syndromes defined by patients and hematologists - EUMDS Registry group study

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Koinig K, Arvandi M, Puntscher S, van Marrewijk C, Fenaux P, Symeonidis A, Chermat F, Garelius H, Bowen D, Mittelman M, Mora E, de Witte T, Efficace F, Siebert U, Stauder R
Published in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Issue 6-dec, 2020, Page(s) 294734; EP817

Development of Core Patient-Reported Outcomes in Myelodysplastic Syndromes

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Koinig K, Arvandi M, Puntscher S, van Marrewijk C, Fenaux P, de Witte T, Efficace F, Siebert U, and Stauder R
Published in: Society for Medical Decision Making (18th) Biennial European Conference; published in: SMDM.org/meetings/archive, Issue (June) Postponed to 2021, 2020

Determinants of Health-Related Quality of Life in Patients with Myelodysplastic Syndromes

Author(s): Stojkov I, Conrads-Frank A, Rochau U, Arvandi M, Koinig K, Schomaker M, Puntscher S, Schmid D, van Marrewijk C, Smith A, de Witte T, Stauder R, and Siebert U
Published in: Society for Medical Decision Making (18th) Biennial European Conference; published in: SMDM.org/meetings/archive, Issue (June) Postponed to 2021, 2020

Quality of Life in MDS: Relevance for Patients, Physicians, and Stakeholders

Author(s): Stauder R.
Published in: 2019 Annual Meeting of the German, Austrian and Swiss Societies of Hematology and Medical Oncology, Issue October, 2019

Relevance of patient-reported outcomes (PROs) in patients with cancer at advanced age

Author(s): Stauder R.
Published in: 2019 Annual Meeting of the German, Austrian and Swiss Societies of Hematology and Medical Oncology, Issue October, 2019

Toxic iron species and oxidative stress in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Author(s): Hoeks M, Bagguley T, van Marrewijk C, Smith A, Bowen D, Culligan D, Macheta M, Symeonidis A, Garelius HKG, Spanoudakis M, Langemeijer S, Roelofs R, Wiegerinck E, Tatic A, Killick S, Panagiotidis P, Stanca O, Hellström-Lindberg E, Čermák J, van der Klauw M, Wouters H, van Kraaij M, Blijlevens N, Swinkels DW and de Witte T, on behalf of the EUMDS Registry Participants
Published in: Leukemia, Issue (under peer review), 2020, ISSN 0887-6925

Computational flow cytometry: a diagnostic tool in MDS

Author(s): Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, van de Loosdrecht AA
Published in: EMSCO 6th annual meeting, Amsterdam, The Netherlands 21-22 sept 2018, published in: unknown, Issue September, 2018

Artificial intelligence for flow cytometry data analysis in suspected-MDS enables an accurate, objective and fast diagnosis

Author(s): Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, Saeys Y, van de Loosdrecht AA
Published in: MDS-Foundation (15th) International symposium on MDS; published in: Unknown, Issue May, 2019

Artificial intelligence improves flow cytometry diagnostics in myelodysplastic syndromes

Author(s): Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, Saeys Y, van de Loosdrecht AA
Published in: Cancer Research UK - New Directions in Immuno-Oncolog, London UK, Published in : unknown, Issue September, 2019

Computational flow cytometry: a novel diagnostic tool in myelodysplastic syndromes

Author(s): Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, van de Loosdrecht AA
Published in: Dutch Hematology Congress 2019, published in: Nederlands Tijdshrift voor Hematologie, Issue October, 2019, ISSN 1572-1590

IJzerchelatie bij laag-risico myelodysplsie


Published in: ISSN 1572-1590

The mutational landscape and microenvironment in Myelodysplastic Syndromes with deletion of chromosome 5q

Author(s): Christian Scharenberg, MD
Published in: Issue 2 March, 2018

Registry studies on myelodysplastic syndrome and secondary acute myeloid leukemia

Author(s): Hege Garelius, MD
Published in: Issue 4 May, 2018

Patients with lower-risk myelodysplastic syndromes: in scope of iron related complications

Author(s): Louise de Swart
Published in: Issue 12 June, 2019

MDS: de juiste zorg op het juiste moment - MDS is een complexe en relatief zeldzame ziekte, maar het aantal patiënten groeit. Het project MDS-RIGHT heeft tot doel de zorg voor MDS-patiënten te verbeteren. Op welke manier?

Author(s): de Witte, T (Gal M)
Published in: HEMATON [In Dutch], Issue Magazine 16 Winter 2017, 2017, Page(s) 28-31

Immuunfenotype als voorspeller voor pregressie bij MDS

Author(s): van Spronsen M
Published in: Nederlands Tijdschrift voor Hematologie [In Dutch], Issue DHC special April, 2018, Page(s) 11, ISSN 1572-1590

Anemie en kwaliteit van leven

Author(s): Wouters HJCM
Published in: Nederlands Tijdschrift voor Hematologie [In Dutch], Issue DHC special April, 2018, Page(s) 12, ISSN 1572-1590

Moleculaire Diagnostiek

Author(s): Jansen J
Published in: Nederlands Tijdschrift voor Hematologie [In Dutch], Issue DHC special April, 2018, Page(s) 54, ISSN 1572-1590

Patiënten met laagrisico-MDS: met het oog op ijzergerelateerde problematiek

Author(s): de Swart L
Published in: Medidact – Hematlogie [In Dutch], Issue Augustus vol. 4 / nr. 4, 2019, Page(s) 18

De nieuwste ontwikkelingen op het gebied van ijzerstapeling bij myelodysplastisch syndroom

Author(s): Hoeks M, Zwaginga JJ
Published in: Hematologie Actueel [In Dutch], Issue Jaargang 19 | nr. 2 | september 2019 [In Dutch], 2019