Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time

Risultati finali

Updated patient handbooks of the national MDS patient groups
Operational project specific MDS-RIGHT website
Yearly electronic updates of the evidence-based therapeutic guidelines

Yearly electronic updates of the evidencebased therapeutic guidelines

Discussion platforms and a common website for stakeholder interaction
Yearly updates of MDS website

Report of two meetings on state-of-the-art in the field of MDS
Report on the endorsement of the new evidence-based guidelines for MDS patients
Final dataset incorporating data generated from WP2, WP3 & WP4
Periodic report on mutational sequencing and epigenetic profiling in various cohorts

Reports on mutational sequencing and epigenetic profiling in various cohorts

Report of ethical, legal, and socio-economical aspects of the elderly low risk MDS population
Completed catalogue of all MDS caregiver cooperative groups, patient support groups and existing documents
Report on the newly defined burden of MDS on HRQoL in MDS and nonMDS cohorts
Report describing the flexible electronic web-based system with evidence-based guidelines for MDS
Yearly MDS Stakeholders Newsletters
Report on the participation in international patient support group meetings.
Report on new COS including patient-reported, disease-specific outcomes
Report of new predictors and prediction functions for impaired HRQoL
Final analyses of models from D1.3 for use in WP5 and WP6
Final report of WP1 and preparation of manuscripts
Validation of a MDS-specific HRQoL questionnaire (QUALMS-1)
A list of HRQoL-adapted treatments for each biologic MDS-subtype
Report on newly generated, high-quality health economic evidence of benefit by personalised MDS care strategies
Periodic report on immunophenotyping in various cohorts
Approved European and International guidelines uploaded at new ELN-linked website
Periodic report on bioinformatic integration of data
Report describing prognostic impact of newly defined individual genetic defects on response to the existing HCI
Report on ms data 100 blood samples with 100 paired BM samples

List of newly identified genetic defects that support development of novel drugs
Report of new specific genetic signatures that support minimal diagnostic criteria recognizing MDS in older individuals
Description of effect estimates for various health-care interventions on HRQoL
Promotion of educational and scientific meetings, pocket cards, posters, flyers, exhibition booth for meetings
A set of measures and prediction functions of HRQoL
Report of early treatment response indicators supporting a targeted use of existing HCI

Scientific, Clinical and Ethics Advisory Board

Appointment of Scientific, Clinical and Ethics Advisory Board

Pubblicazioni

Moleculaire diagnostiek

Autori: Jansen J
Pubblicato in: Dutch Hematology Congress 2018, published in: Nederlands Tijdshrift voor Hematologie, Numero DHC special April, 2018, ISSN 1572-1590
Editore: Ariez B.V.

Immuunfenotype als voorspeller oor progressie bij MDS

Autori: van Spronsen et al.
Pubblicato in: Dutch Hematology Congress 2018, published in: Nederlands Tijdshrift voor Geneeskunde, Numero DHC special April, 2018, ISSN 1572-1590
Editore: Ariez B.V.

DTUrtle – Differential transcript usage analysis for bulk and single-cell data

Autori: Tekath T, Dugas M
Pubblicato in: 28th International Conference on Intelligent Systems for Molecular Biology (ISMB) 2020, Numero 31 July 2020, 2020, ISSN 2046-1402
Editore: F1000 Research Ltd

A variant erythroferrone induced by clonal erythropoiesis disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome

Autori: Bondu S
Pubblicato in: 2019
Editore: ?

A variant erythroferrone induced by clonal erythropoiesis disrupts iron homeostasis in SF3B1-mutated myelodysplastic syndrome

Autori: Bondu S
Pubblicato in: 2020
Editore: ?

Longitudinal Study on Determinants of Health-Related Quality of Life in Patients with Myelodysplastic Syndromes

Autori: Stojkov I, Conrads-Frank A, Rochau U, Arvandi M, Koinig KA, Schomaker M, Fenaux P, Bowen D, Symeonidis A, Mittelman M, Cermak J, Sanz GF, Hellstrom Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Madry K, Guerci Bresler A, Culligan DJ, Kotsianidis I, Sanhes L, Mills J, Puntscher S, Schmid D, van Marrewijk C, Smith A, de Witte T, Siebert U, Stauder R
Pubblicato in: American Society of Hematology 2020 (62nd) Annual meeting; published in: Blood, Numero December 2020, 2020
Editore: American Society of Hematology

Diagnose en prognose van MDS [In Dutch]

Autori: vd Loosdrecht AA
Pubblicato in: Dutch Hematology Congress 2020, published in: Nederlands Tijdshrift voor Hematologie, 2020, ISSN 1572-1590
Editore: Ariez B.V.

Determinants of Health-Related Quality of Life in Patients with Myelodysplastic Syndromes

Autori: Stojkov I, Conrads-Frank A, Rochau U, Arvandi M, Koinig K, Schomaker M, Puntscher S, Schmid D, van Marrewijk C, Smith A, de Witte T, Stauder R, Siebert U
Pubblicato in: 42nd Annual North American Meeting of the Society for Medical Decision Making; published in: Med Decis Making, Numero October 2020, 2020
Editore: Society for Medical Decision Making

Impact of Treatment with Iron Chelation Therapy in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Autori: Hoeks M, Yu G, Langemeijer S, Crouch S, de Swart L, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Skov-Holm M, Mittelman M, Madry K, Malcovati L, Tatic A, Almeida AM, Germing U, Savic A, Gredelj-Šimec N, Culligan D, Itzykson R, Guerci-Bresler A, Slama B, van Marrewijk C, Droste J, van Kraaij M, Bowen DT, de Witte TM, Smith A.
Pubblicato in: Blood, Numero 130, S1, 2017, Pagina/e "#425"
Editore: American Society of Hematology

Identifying Predictors for Low Health-Related Quality of Life in Patients with Myelodysplastic Syndromes – Research Protocol

Autori: Stojkov I, Conrads-Frank A, Rochau U, Koinig KA, Arvandi M, Efficace F, Stauder R, Siebert U
Pubblicato in: Annual Conference of the German Network for Evidence-based Medicine, 2018
Editore: German Medical Science Publishing House

Impact of Treatment with Iron Chelation Therapy in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Autori: Hoeks M, Yu G, Langemeijer S, Crouch S, de Swart L, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Skov-Holm M, Mittelman M, Madry K, Malcovati L, Tatic A, Almeida AM, Germing U, Savic A, Gredelj-Šimec N, Culligan D, Itzykson R, Guerci-Bresler A, Slama B, van Marrewijk C, Droste J, van Kraaij M, Bowen DT, de Witte TM, Smith A.
Pubblicato in: Dutch Hematology Congress 2018, published in: Nederlands Tijdshrift voor Geneeskunde, 2018
Editore: Ariez B.V.

Impact of anemia on health-related quality of life depends on age and etiology

Autori: Wouters HJCM, Van der Klauw MM, de Witte T, Stauder R, Swinkels DW, Wolffenbuttel BHR, Huls G
Pubblicato in: Dutch Hematology Congress 2018 (Nederlands Tijdshrift voor Geneeskunde), 2018
Editore: Ariez B.V.

Impact of Red Blood Cell Transfusion Intensity on Progression-Free Survival in Lower-Risk MDS Patients Included in the European Leukemianet MDS Registry

Autori: de Swart L, Crouch S, Hoeks M, Smith A, Langemeijer S, Fenaux P, Symeonidis A, Cermak J, Stauder R, Mittelman M, Sanz G, Hellstrom-Lindberg E, Malcovati L, Holm MS, Germing U, Madry K, Almeida AM, Tatic A, Savic A, Gredelj-Šimec N, Guerci Bresler A, Culligan D, Itzykson R, Beyne-Rauzy O, Park S, van Marrewijk C, Blijlevens NMA Bowen DT, de Witte TM.
Pubblicato in: Blood, Numero 130, S1, 2017, Pagina/e "#1690"
Editore: American Society of Hematology

Identifying Multinational Cost Data: A Methodological Review and Case Study

Autori: Thomas Patton, Chu-Mei Hung, Martin Henriksson, Mirjana Huić, Ana Patrícia Marques, Sibylle Puntscher, Đurđa Vukićević, Matteo Ruggeri, Andrea Manca
Pubblicato in: EUHEA conference 2018, Maastricht, Numero July 2018, 2018
Editore: European Health Economics Association

Appreci8: a pipeline for precise variant calling integrating 8 tools

Autori: Sandmann S, de Graaf AO, Karimi M, van der Reijden BA, Hellström-Lindberg E, Jansen JH, Dugas M
Pubblicato in: Haematologica, Numero 102,S2, Jun 26, 2017
Editore: Ferrata Storti Foundation

Deriving Core Outcomes for Myelodysplastic Syndromes – Health Professionals’ Perspective

Systematic Overview of Patient-Reported Outcomes for Myelodysplastic Syndromes

Autori: Stojkov I, Rochau U, Conrads-Frank A, Borba HH, Koinig KA, Arvandi M, Efficace F, Stauder R, Siebert U.
Pubblicato in: 17th Biennial European Conference of the Society for Medical Decision Making, 2018
Editore: Sage Publishing

Developing a Core Outcomes for Myelodysplastic Syndromes – The MDS-RIGHT Health Professional Delphi Survey

Autori: Stojkov I, Conrads-Frank A, Rochau U, Koinig K.A., Arvandi M, Symeonidis A, Sanz G, Fenaux P, Bowen D, Mittelmann M, Garelius H, Germing U, van Marrewijk C , Cermak J, Hellström-Lindberg E, Smith A, de Witte T, Efficace F, Siebert U, Stauder R.
Pubblicato in: 23rd Congress of the European Hematology Association; published in: Haematologica, Numero 103, S1 (June 2018), 2018
Editore: Ferrata Storti Foundation

Prognostic Value of Early Drop in Platelets in Lower-Risk MDS. A Sub-Study from the European Leukemianet Lower-Risk MDS (EUMDS) Registry

Autori: Itzykson R, Smith A, Fenaux P, Symeonidis A, Mittelman M, Stauder R, Sanz G, Cermak J, Hellstrom-Lindberg E, Malcovati L, Langemeijer S, Germing U, Madry KM, Holm MS, Tatic A, Almeida AM, Savic A, Gredelj-Šimec N, Bowen D, de Witte T.
Pubblicato in: Leukemia Research, Numero 55, S1, 2017, Pagina/e "#19, S10-11"
Editore: Pergamon Press Ltd.

Impact of Red Blood Cell Transfusion Rate, Adjusted by Therapeutic interventions, on Progression-Free Survival in Lower-Risk MDS Patients within the European LeukemiaNet MDS Registry

Autori: de Swart L, Hoeks M, Crouch S, Smith A, Langemeijer S, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Stauder R, Sanz G, Mittelman M, Holm MS, Malcovati L, Madry K, Germing U, Savic A, Almeida AM, Guerci Bresler A, Itzykson R, Beyne-Rauzy O, Culligan D, van Marrewijk C, Blijlevens NMA Bowen DT, de Witte TM.
Pubblicato in: Haematologica, Numero 103, S1, 2018
Editore: Ferrata Storti Foundation

Benchmarking Variant Calling Tools for NGS Data

Autori: Sandmann S, de Graaf AO, Karimi M, van der Reijden BA, Hellström-Lindberg E, Jansen JH, Dugas M
Pubblicato in: F1000Research, Numero 6(ISCB Comm J):1353, 2017
Editore: F1000 Research Ltd

Health-Related Quality of Life Is Substantially Impaired in Lower-Risk MDS When Compared with Reference Populations and Significantly Affects Overall Survival

Autori: Stauder R, Yu G, Koinig K, Fenaux P, Symeonidis A, Sanz G, Cermak J, Mittelman M, Hellstrom-Lindberg E, Langemeijer S, Holm MS, Madry K, Malcovati L, Tatic A, Germing U, Savic A, Efficace F, Smith A, Bowen D, de Witte T.
Pubblicato in: Leukemia Research, Numero 55, S1, 2017, Pagina/e "#22, S12"
Editore: Elsevier

Impact of Red Blood Cell Transfusions on Survival in Lower-Risk MDS Patients Included in the European Leukemianet MDS (EUMDS) Registry

Autori: de Swart L, Crouch S, Smith A, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Malcovati L, Germing U, Langemeijer S, Holm MS, Mittelman M, Mądry K, Almeida A, Savic A, Itzykson R, Bowen D, de Witte T.
Pubblicato in: Leukemia Research, Numero 55, S1, 2017, Pagina/e "#280, S160-161"
Editore: Pergamon Press Ltd.

A Prognostic Classifier Based on Early Platelet Drop in Lower-Risk MDS a Study from the European Leukemianet Lower-Risk MDS (EUMDS) Registry

Autori: Itzykson R, Crouch S, Smith A, Symeonidis A, Hellstrom-Lindberg E, Sanz G, Cermak J, Stauder R, Malcovati L, Germing U, Mittelman M, Langemeijer S, Madry K, Tatic A, Holm MS, Almeida AM, Savic A, Gredelj-Šimec N, Luño Fernandez E, Culligan D, Guerci Bresler A, van Marrewijk C, Bowen DT, de Witte TM, Fenaux P.
Pubblicato in: Blood, Numero 130, S1, 2017, Pagina/e "#158"
Editore: American Society of Hematology

Detecting small structural variants in amplicon-based NGS data - an evaluation of ten algorithms

Autori: Marius Wöste, Sarah Sandmann, Aniek de Graaf, Bert van der Reijden, Joop Jansen, and Martin Dugas
Pubblicato in: ISMB abstrats, 2017
Editore: F1000Research

Developing a Core Outcome Set for Myelodysplastic Syndromes - an International Delphi Survey

Autori: Stojkov I, Rochau U, Conrads-Frank A, Koinig K.A., Arvandi M, Symeonidis A, Sanz G, Fenaux P, Bowen D, Mittelmann M, Garelius H, Germing U, van Marrewijk C , Cermak J, Hellström-Lindberg E, Smith A, de Witte T, Efficace F, Stauder R, Siebert U.
Pubblicato in: 40th Annual North American Meeting of the Society for Medical Decision Making, Numero october 2018, 2018
Editore: F1000 Research Ltd

Impact van behandeling met ijzerchelatietherapie op patiënten met een laag-risico myelodysplastisch syndroom die deelnemen aan de Europese MDS registratie

Systematic Review of Quality of Life Measurement Instruments and Response Criteria among Patients with Myelodysplastic Syndromes

Autori: Stojkov I, Rochau U, Borba HH, Jevdjevic M, Koinig KA, Arvandi M, Efficace F, Stauder R, Siebert U.
Pubblicato in: ISPOR 19th Annual European Congress; published in: Value in Health, Numero 19/7 (October 2016), 2016, Pagina/e A596, ISSN 1098-3015
Editore: Blackwell Publishing Inc.

Impact of Treatment with Iron Chelators in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry

Autori: Saskia Langemeijer, Louise De Swart, Ge Yu, Alex Smith, Simon Crouch, Tom Johnston, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Eva Hellstrom-Lindberg, Guillermo Sanz, Reinhard Stauder, Luca Malcovati, Ulrich Germing, Mette Skov Holm, Moshe Mittelman, Krzysztof Madry, Aurelia Tatic, Antonio Almeida, Aleksandar Savic, Sophie Park, Odile Beyne-Rauzy, Raphaël Itzykson, Corine van Marrewijk,
Pubblicato in: Blood, Numero 128, 2016, Pagina/e 3186
Editore: American Society of Hematology

Comparison of 1690 MDS Patients from the European LeukemiaNet Registry and Reference Populations - Evidence for a Significant impairment in QoL in MDS and Definition of Predictors of Diminished QoL

Autori: Reinhard Stauder , Ge Yu , Tim Bagguley , Pierre Fenaux , Argiris Symeonidis , Guillermo Sanz , Jaroslav Cermak , Moshe Mittelman , Eva Hellström-Lindberg , Saskia Langemeijer , Mette Skov Holm , Krzysztof Mądry , Luca Malcovati , Aurelia Tatic , Ulrich Germing , Aleksandar Savic , Corine van Marrewijk , Agnès Guerci-Bresler , Elisa Luño , Jackie Droste , Karin Koinig , Alex Smith , David Bowe
Pubblicato in: Hematologica, Numero Volume: 101 Pages: 16-17 Supplement: 1 Meeting Abstract: S13, 2016
Editore: Ferrata Storti Foundation

Systematic Overview of Response Criteria among Patients with Myelodysplastic Syndromes

Autori: I Stojkov, U Rochau, HH Borba, M Jevdjevic, K Koinig, M Arvandi, F Efficace, R Stauder, U Siebert
Pubblicato in: Society for Medical Decision Making, 38th Annual North American Meeting; published in Value in Health, Numero 19/7, 2016, Pagina/e A596 (PSY119), ISSN 1098-3015
Editore: Blackwell Publishing Inc.

Elevated Labile Plasma Iron Levels (LPI) and Increased Oxidative Stress Are Associated with Red Blood Cell Transfusions in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) Subtitle: from the European Leukemianet MDS Registry

Autori: Marlijn Hoeks, Saskia Langemeijer, Louise De Swart, Tim Bagguley, Corine van Marrewijk, David Bowen, Jaroslav Cermak, Eva Hellstrom-Lindberg, Aurelia Tatic, Argiris Symeonidis, Marian G.J. Van Kraaij, Panagiotis Panagiotidis, Hege Garelius, Dominic J Culligan, Marta Krejci, Jackie Droste, Alexandra Smith, Dorine W. Swinkels and Theo de Witte
Pubblicato in: Blood, Numero 128, 2016, Pagina/e 4327
Editore: The American Society of Hematology

Evaluating and Optimizing Variant Calling: A Comparison of Roche 454, Ion Torrent PGM and Illumina NextSeq Sequencing Data

Autori: Sarah Sandmann, Aniek de Graaf, Bert van der Reijden, Joop Jansen and Martin Dugas
Pubblicato in: F1000Research, 2015
Editore: F1000Research

Confident Variant Calling in NGS Data – A Mission Impossible?

Autori: Sarah Sandmann, Aniek de Graaf, Bert van der Reijden, Joop Jansen and Martin Dugas
Pubblicato in: F1000Research, 2016
Editore: F1000Research

Elevated Labile Plasma Iron (LPI) Levels in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) Are Associated with Decreased Quality of Life and Reduced Survival

Autori: Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellström-Lindberg E, Tatic A, Langemeijer S, Culligan DJ, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels DW, and de Witte TM
Pubblicato in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Numero 132, S1, 2018, Pagina/e 4392
Editore: American Society of Hematology

DTUrtle – an easily accessible Differential Transcript Usage analysis pipeline

Autori: Tekath T, Dugas M
Pubblicato in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Numero 14-Aug, 2019, Pagina/e 8-1434, ISSN 2046-1402
Editore: F1000 Research Ltd

New prognostic indicators in MDS identified during the first 10 years of the EUropean LeukemiaNet MDS (EUMDS) Registry

Autori: de Witte T, Fenaux P, Bowen D, Symeonidis A, Mittelman M, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Langemeijer S, Germing U, Holm MS, Mądry K, Tatic A, Almeida AM, Savic A, Gredelj Šimec N, Itzykson R, Culligan D, Kotsianidis I, Ades L, van de Loosdrecht AA, van Marrewijk C, Yu G, Crouch S, Malcovati L, Smith A, on behalf of the EUMDS Registry Participants
Pubblicato in: MDS-Foundation (15th) International symposium on MDS; published in: Leukemia Research, 2019
Editore: Pergamon Press Ltd.

Can We Diagnose MDS without Bone Marrow Examination? a Proposed EUMDS-Based Non-Invasive Diagnostic Model

Autori: Oster HS, Shrkihe BA, Crouch S, Smith A, Yu G, Carmi G, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Cermak J, Sanz G, Hellstrom-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Madry K, Tatic A, Almeida AM, Savic A, Gredelj-Šimec N, Guerci Bresler A, van Marrewijk C, Bowen DT, de Witte TMM, Mittelman M
Pubblicato in: American Society of Hematology 2017 (59th) Annual meeting; published in: Blood, Numero 130, S1, 2017, Pagina/e 2975
Editore: American Society of Hematology

Deriving Core Patient-Reported Outcomes in Patients with Myelodysplastic Syndromes - a Delphi Survey from the European-MDS Registry

Autori: Stojkov I, Conrads-Frank A, Rochau U, Koinig KA, Borba H, Arvandi M, Fenaux P, Symeonidis A, Bowen DT, Mittelman M, van Marrewijk C, de Witte T, Efficace F, Siebert U and Stauder R
Pubblicato in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Numero 132, S1, 2018, Pagina/e 2295
Editore: American Society of Hematology

Transfusie-afhankelijkheid is geassocieerd met de aanwezigheid van toxische ijzersoorten en slechtere overleving bij patiënten met een laag-risico myelodysplastisch syndroom

Autori: Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellstrom-Lindberg E, Tatic A, Langemeijer S, Culligan D, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels D, de Witte T
Pubblicato in: Nederlandse Vereniging voor Bloedtransfusie - TRIP Symposium 2019; published in: unknown, 2019, Pagina/e "#27"
Editore: unknown

I-CARE for MDS: Development of Guidelines-Based Indicators for Appropriate Care in Adult Patients with Myelodysplastic Syndromes

Autori: Stojkov K, Silzle T, Stussi G, Schwappach D, Bernhard J, Bowen D, Čermák J, Dinmohamed A, Eeltink C, Eggmann S, Fenaux P, Germing U, Haschke M, Hellstrom-Lindberg E, Heger M, van de Loosdrecht AA, Passweg J, Pfeilstöcker M, Platzbecker U, Malcovati L, Almeida AM, Mittelman M, Morgenthaler C, Steensma D, Santini V, Stauder R, Symeonidis A, Schaer S, Maddox C, de Witte T, Bohlius J, Bonadies N
Pubblicato in: American Society of Hematology 2019 (61th) Annual meeting; published in: Blood, Numero 134, S1, 2019, Pagina/e 4752
Editore: American Society of Hematology

Transfusion dependancy is associated with presence of toxic iron species and inferior survival in patients with lower-risk myelodysplastic syndromes

Autori: Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellstrom-Lindberg E, Tatic A, Langemeijer S, Culligan D, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels D, de Witte T
Pubblicato in: International Society of Blood Transfusion (29th) Regional Congress; published in: unknown, 2019
Editore: unknown

Clonal evolution in MDS

Autori: Jansen J
Pubblicato in: European hematology Association 2017 (22nd) Congress; published in: EHA open access library, 2017
Editore: European Hematology Association

Consensus on a Core Outcome Set for Myelodysplastic syndromes

Autori: Rochau U, Stojkov I, Conrads-Frank A, Borba H, Koining K, Arvandi M, van Marrewijk C, Garelius H, Germing U, Symeonidis A, Sanz G, Fenaux P, de Witte T, Efficace F, Siebert U, Stauder R.
Pubblicato in: MDS-Foundation (15th) International symposium on MDS; published in: Leukemia Research, 2019
Editore: Pergamon Press Ltd.

Excess Mortality in Low-Risk MDS Can be Explained By MDS and AML Related Causes of Death

Autori: Mądry K, Yu G, Lis K, Fenaux P, Bowen D, Symeonidis A, Mittelman M, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Guerci-Bresler A, Culligan D, Sanhes L, Mills J, Kotsianidis I, van Marrewijk C, Couch S, de Witte T, Smith A, on behalf of the EUMDS Registry Participants
Pubblicato in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Numero 132, S1, 2018, Pagina/e 4385
Editore: American Society of Hematology

Transfusion dependancy is associated with presence of toxic iron species and inferior survival in patients with lower-risk myelodysplastic syndromes

Autori: Hoeks M, Bagguley T, Roelofs R, de Swart L, Bowen D, Symeonidis A, van Marrewijk C, Hellstrom-Lindberg E, Tatic A, Langemeijer S, Culligan D, Macheta M, Garelius H, Spanoudakis M, Killick S, Panagiotidis P, Stanca Ciocan O, Mills J, Pottinger B, Ackroyd S, Hall C, Droste J, Smith A, Swinkels D, de Witte T
Pubblicato in: European hematology Association 2019 (24th) Congress; published in: EHA open access library, Numero 15-Jun, 2019, Pagina/e 267421; S838
Editore: European Hematology Association

"Appreci8R: an R package for calling variants the ""appreci8""-way"

Autori: Sandmann S, Dugas M
Pubblicato in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Numero 12-Aug, 2019, Pagina/e 8-1414, ISSN 2046-1402
Editore: F1000 Research Ltd

Labile Plasma Iron (LPI) Is a Clinical Indicator of Overt Iron Overload in Patients with Lower-Risk Myelodysplastic Syndromes (MDS) from the European Leukemianet MDS Registry

Autori: de Swart L, Reiniers C, Bagguley T, Bowen D, Cermak J, Hellstrom-Lindberg E, Tatic A, Symeonidis A, Huls G, Panagiotidis P, Garelius H, Culligan D, Krejci M, van Marrewijk C, Droste J, Smith A, Swinkels DW, de Witte T
Pubblicato in: American Society of Hematology 2015 (57th) Annual meeting; published in: Blood, Numero 126/23, 2015, Pagina/e 2865
Editore: American Society of Hematology

Longitudinal Changes of Impairments in Health-Related Quality of Life in Lower-Risk MDS Patients: A European Leukemianet Study

Autori: Stauder R, Yu G, Koinig KA, Culligan D, Fenaux P, Cermak J, Symeonidis A, Bernal T, Hellström-Lindberg E, Mittelman M, Langemeijer S, Holm MS, Mills J, Guerci-Bresler A, van Marrewijk C, Garelius H, Efficace F, Smith A, Bowen D, and de Witte TM
Pubblicato in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Numero 132, S1, 2018, Pagina/e 3097
Editore: American Society of Hematology

How to “appreci8” Variant Calling in NGS Data

Autori: Sandmann S, Dugas M
Pubblicato in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Numero 20-Dec, 2019, Pagina/e 8-2128, ISSN 2046-1402
Editore: F1000 Research Ltd

A Web Application Could Help in MDS Diagnosis and Obviate the Bone Marrow Examination

Autori: Oster H, Crouch S, Smith A, Yu G, Abu Shrkihe B, Shoham B, Kolomansky A, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Malcovati L, Germing U, Holm MS, Guerci- Bresler A, Culligan D, Laurence S, Mills J, Kotsianidis I, van Marrewijk C, Bowen D, de Witte T, Mittelman M.
Pubblicato in: MDS-Foundation (15th) International symposium on MDS; published in: Leukemia Research, 2019
Editore: Pergamon Press Ltd.

Prognostic Impact of Transfusions Intensity on Survival and Development of Thrombocytopenia in Newly Diagnosed Lower-Risk MDS Patients Participating in the European Leukemianet EUMDS Registry

Autori: de Swart L, Johnston T, Smith A, Fenaux P, Symeonidis A, Cermak J, Hellstrom-Lindberg E, Sanz G, Stauder R, Malcovati L, Germing U, Huls G, Holm MS, Mittelman M, Madry K, Tatic A, Almeida AM, Savic A, Park S, Beyne-Rauzy O, Itzykson R, van Marrewijk C, Bowen D, de Witte T
Pubblicato in: American Society of Hematology 2015 (57th) Annual meeting; published in: Blood, Numero 126/23, 2015, Pagina/e 1677
Editore: American Society of Hematology

Immunophenotypically Aberrant Stem Cells in Myelodysplastic Syndromes: A Biomarker for Leukemic Progression

Autori: Margot F. Van Spronsen, Theresia M. Westers, Birgit I. Witte, Gert J. Ossenkoppele, Arjan A. Van de Loosdrecht
Pubblicato in: American Society of Hematology 2017 (59th) Annual meeting; published in: Blood, Numero 130, S1, 2017, Pagina/e 4240
Editore: American Society of Hematology

AMLVaran: Improvements in user-friendlyness of a human NGS variant assessment system

Autori: Wünsch C, Dugas M
Pubblicato in: Intelligent Systems for Molecular Biology (27th) and European Conference on Computational Biology (18th) Annual International Conference; published in: F1000Research, Numero 30-Jul, 2019, Pagina/e 8-1232, ISSN 2046-1402
Editore: F1000 Research Ltd

MDS Diagnosis: Many Patients May Not Require Bone Marrow Examination

Autori: Oster HS, Crouch S, Smith A, Yu G, Abu Shrkihe B, Baruch S, Kolomansky A, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Cermak J, Sanz G, Hellström-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Madry K, Guerci-Bresler A, Culligan D, Sanhes L, Mills J, Kotsianidis I, van Marrewijk C, Bowen D, de Witte T and Mittelman M
Pubblicato in: American Society of Hematology 2018 (60th) Annual meeting; published in: Blood, Numero 132, S1, 2018, Pagina/e 4357
Editore: American Society of Hematology

The anemia-independant effect of Myelodysplastic Syndromes on Health-Related Quality of Life

Autori: Wouters H, Conrads-Frank A, Koinig KA, Smith A, Yu G, de Witte T, Wolffenbuttel B, Huls G, Siebert U, Stauder R, van der Klauw M
Pubblicato in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Numero 6-dec, 2020, Pagina/e 295150; S331
Editore: European Hematology Association

Assessing the Determinants of Health-Related Quality of Life in patients with Myelodysplastic Syndromes

Autori: Stojkov I, Conrads-Frank A, Rochau U, Arvandi M, Koinig KA, Schomaker M, Puntscher S, Schmid D, van Marrewijk C, Smith A, de Witte T, Siebert U, Stauder R
Pubblicato in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Numero 6-dec, 2020, Pagina/e 294713; EP796
Editore: European Hematology Association

Impact of Erythropoietin Stimulation Agents and Red Blood Cell Transfusion on Health-related Quality of Life in Lower-risk Myelodysplastic Syndrome

Autori: Garelius H, Smith A, Appleton S, Bowen D, Fenaux P, Symeonidis A, Mittelman M, Stauder R, Čermák J, Sanz G, Langemeijer S, Holm MS, Itzykson R, Culligan D, Heibl S, Mills J, Bernal T, Kotsianidis I, Ades L, Koinig K, van Marrewijk C, Crouch S, de Witte T, Hellström-Lindberg E
Pubblicato in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Numero 6-Dec, 2020, Pagina/e 294733; EP816
Editore: European Hematology Association

Consensus set of Core Patient-Reported Outcomes for Myelodysplastic Syndromes defined by patients and hematologists - EUMDS Registry group study

Autori: Stojkov I, Conrads-Frank A, Rochau U, Koinig K, Arvandi M, Puntscher S, van Marrewijk C, Fenaux P, Symeonidis A, Chermat F, Garelius H, Bowen D, Mittelman M, Mora E, de Witte T, Efficace F, Siebert U, Stauder R
Pubblicato in: Virtual 25th Congress of European Hematology Association; published in EHA open access library, Numero 6-dec, 2020, Pagina/e 294734; EP817
Editore: European Hematology Association

Development of Core Patient-Reported Outcomes in Myelodysplastic Syndromes

Autori: Stojkov I, Conrads-Frank A, Rochau U, Koinig K, Arvandi M, Puntscher S, van Marrewijk C, Fenaux P, de Witte T, Efficace F, Siebert U, and Stauder R
Pubblicato in: Society for Medical Decision Making (18th) Biennial European Conference; published in: Med Decis Making, Numero PS1-20 (June) Postponed to 2022, 2020
Editore: unknown

Determinants of Health-Related Quality of Life in Patients with Myelodysplastic Syndromes

Autori: Stojkov I, Conrads-Frank A, Rochau U, Arvandi M, Koinig K, Schomaker M, Puntscher S, Schmid D, van Marrewijk C, Smith A, de Witte T, Stauder R, and Siebert U
Pubblicato in: Society for Medical Decision Making (18th) Biennial European Conference, Numero TRA-1-2 (June 2020) Postponed to 2022, 2020
Editore: unknown

Quality of Life in MDS: Relevance for Patients, Physicians, and Stakeholders

Autori: Stauder R.
Pubblicato in: 2019 Annual Meeting of the German, Austrian and Swiss Societies of Hematology and Medical Oncology, Numero October, 2019
Editore: unknown

Relevance of patient-reported outcomes (PROs) in patients with cancer at advanced age

Autori: Stauder R.
Pubblicato in: 2019 Annual Meeting of the German, Austrian and Swiss Societies of Hematology and Medical Oncology, Numero October, 2019
Editore: unknown

Computational flow cytometry: a diagnostic tool in MDS

Autori: Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, van de Loosdrecht AA
Pubblicato in: EMSCO 6th annual meeting, Amsterdam, The Netherlands 21-22 sept 2018, published in: unknown, Numero September, 2018
Editore: unknown

Artificial intelligence for flow cytometry data analysis in suspected-MDS enables an accurate, objective and fast diagnosis

Autori: Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, Saeys Y, van de Loosdrecht AA
Pubblicato in: MDS-Foundation (15th) International symposium on MDS; published in: Unknown, Numero May, 2019
Editore: 1452126

Artificial intelligence improves flow cytometry diagnostics in myelodysplastic syndromes

Autori: Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, Saeys Y, van de Loosdrecht AA
Pubblicato in: Cancer Research UK - New Directions in Immuno-Oncolog, London UK, Published in : unknown, Numero September, 2019
Editore: unknown

Computational flow cytometry: a novel diagnostic tool in myelodysplastic syndromes

Autori: Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, van de Loosdrecht AA
Pubblicato in: Dutch Hematology Congress 2019, published in: Nederlands Tijdshrift voor Hematologie, Numero October, 2019, ISSN 1572-1590
Editore: Ariez B.V.

Mutation Profiles Identify Distinct Clusters of Lower Risk Myelodysplastic Syndromes with Unique Clinical and Biological Features and Clinical Endpoints

Autori: Malcovati L , Crouch S, de Graaf AO, Sandmann S, Tobiasson M, Kosmider O, van der Reijden BA, Painter D , van de Loosdrecht AA , Symeonidis A, Cermak J, Clappier E, Preudhomme C, Staudern R, Mittelman M, Germing U, Bowen D, Fenaux P, van Marrewijk C, Smith A, Dugas M, Hellstrom Lindberg E, de Witte TM , Fontenay M, Jansen J
Pubblicato in: American Society of Hematology 2020 (62nd) Annual meeting; published in: Blood, Numero 136/S1 (5 November 2020), 2020, Pagina/e 29
Editore: American Society of Hematology

A Web Application Could Help Diagnose or Exclude MDS, Providing a Noninvasive Alternative to Bone Marrow Examination

Autori: Oster H, Crouch S, Smith A, Yu G, Ben-Ezra J, Fenaux P, Symeonidis A, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Mądry K, Guerci- Bresler A, Culligan D, Laurence S, Mills J, Kotsianidis I, van Marrewijk C, Bowen D, de Witte T, Mittelman M.
Pubblicato in: American Society of Hematology 2019 (61th) Annual meeting; Submitted, 2019
Editore: -

Analyzing coverage in smMIPs data

Autori: Sandmann S, de Graaf AO, Jansen JH, Dugas M
Pubblicato in: German Conference on Bioinformatics (2020); published in: F1000Research, Numero 29 September 2020, 2020, ISSN 2046-1402
Editore: F1000 Research Ltd

How to “appreci8” Variant Calling in NGS Data

Autori: Sandmann S, Dugas M
Pubblicato in: German Conference on Bioinformatics, Numero September 2019, 2019
Editore: ?

Delphi-Survey-Based Development of Core Patient-Reported Outcomes in Myelodysplastic Syndromes

Autori: Stojkov I, Conrads-Frank A, Rochau U, Koinig KA, Arvandi M, Puntscher S, van Marrewijk C, Fenaux P, de Witte T, Efficace F, Siebert U, Stauder R
Pubblicato in: 42nd Annual North American Meeting of the Society for Medical Decision Making; published in: Med Decis Making, Numero October 2020, 2020
Editore: Society for Medical Decision Making

Mutatiespectrum en dynamiek van klonale hematopoése bij ouderen met anemie [In Dutch]

Autori: van Zeventer et al.
Pubblicato in: Dutch Hematology Congress 2020, published in: Nederlands Tijdshrift voor Hematologie, 2020, ISSN 1572-1590
Editore: Ariez B.V.

Distinct bone marrow immunophenotypic features define the splicing factor 3B subunit 1 ( SF3B1 )‐mutant myelodysplastic syndromes subtype

Autori: Carolien Duetz, Theresia M. Westers, Florentien E. M. in ’t Hout, Eline M. P. Cremers, Canan Alhan, Bianca Venniker‐Punt, Heleen A. Visser‐Wisselaar, Dana A. Chitu, Aniek O. Graaf, Linda Smit, Joop H. Jansen, Arjan A. Loosdrecht
Pubblicato in: British Journal of Haematology, Numero 193/4, 2021, Pagina/e 798-803, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.17414

Impact of red blood cell transfusion dose density on progression-free survival in patients with lower-risk myelodysplastic syndromes

Autori: Louise de Swart, Simon Crouch, Marlijn Hoeks, Alex Smith, Saskia Langemeijer, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermâk, Eva Hellström-Lindberg, Reinhard Stauder, Guillermo Sanz, Moshe Mittelman, Mette Skov Holm, Luca Malcovati, Krzysztof Mądry, Ulrich Germing, Aurelia Tatic, Aleksandar Savic, Antonio Medina Almeida, Njetocka Gredelj-Simec, Agnes Guerci-Bresler, Odile Beyne-Rauzy, Domi
Pubblicato in: Haematologica, Numero 105/3, 2020, Pagina/e 632-639, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.212217

CopyDetective: Detection threshold–aware copy number variant calling in whole-exome sequencing data

Autori: Sarah Sandmann, Marius Wöste, Aniek O de Graaf, Birgit Burkhardt, Joop H Jansen, Martin Dugas
Pubblicato in: GigaScience, Numero 9/11, 2020, Pagina/e giaa118, ISSN 2047-217X
Editore: Oxford University Press and the Beijing Genomics Institute
DOI: 10.1093/gigascience/giaa118

Multicenter Next-Generation Sequencing Studies between Theory and Practice

Autori: Sarah Sandmann, Aniek O. de Graaf, Magnus Tobiasson, Olivier Kosmider, María Abáigar, Emmanuelle Clappier, Anna Gallì, Bert A. van der Reijden, Luca Malcovati, Pierre Fenaux, María Díez-Campelo, Michaela Fontenay, Eva Hellström-Lindberg, Joop H. Jansen, Martin Dugas
Pubblicato in: The Journal of Molecular Diagnostics, Numero 23/3, 2021, Pagina/e 347-357, ISSN 1525-1578
Editore: American Society for Investigative Pathology
DOI: 10.1016/j.jmoldx.2020.12.001

Immunophenotypic aberrant hematopoietic stem cells in myelodysplastic syndromes: a biomarker for leukemic progression

Autori: van Spronsen M, Hanekamp D, Westers T, Jansen J, Lissenberg-Witte B, Cloos J, Schuurhuis G, van de Loosdrecht AA
Pubblicato in: Blood, Numero (under peer-review), 2021, ISSN 0006-4971
Editore: American Society of Hematology

Computational flow cytometry as a diagnostic tool in suspected-myelodysplastic syndromes.

Autori: Duetz C, van Gassen S, Westers TM, van Spronsen MF, Bachas C, Saeys Y, van de Loosdrecht AA
Pubblicato in: Cytometry A., Numero (under peer-review - conditionally accepted with minor changes), 2021, ISSN 1552-4922
Editore: John Wiley & Sons Ltd.

Labile plasma iron levels predict survival in patients with lower-risk myelodysplastic syndromes

Autori: Louise de Swart, Chloé Reiniers, Timothy Bagguley, Corine van Marrewijk, David Bowen, Eva Hellström-Lindberg, Aurelia Tatic, Argiris Symeonidis, Gerwin Huls, Jaroslav Cermak, Arjan A. van de Loosdrecht, Hege Garelius, Dominic Culligan, Mac Macheta, Michail Spanoudakis, Panagiotis Panagiotidis, Marta Krejci, Nicole Blijlevens, Saskia Langemeijer, Jackie Droste, Dorine W. Swinkels, Alex Smith, The
Pubblicato in: Haematologica, Numero 103/1, 2017, Pagina/e 69-79, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2017.171884

GLM-based optimization of NGS data analysis: A case study of Roche 454, Ion Torrent PGM and Illumina NextSeq sequencing data

Autori: Sarah Sandmann, Aniek O. de Graaf, Bert A. van der Reijden, Joop H. Jansen, Martin Dugas
Pubblicato in: PLOS ONE, Numero 12/2, 2017, Pagina/e e0171983, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0171983

BBCAnalyzer: a visual approach to facilitate variant calling

Autori: Sarah Sandmann, Aniek O. de Graaf, Martin Dugas
Pubblicato in: BMC Bioinformatics, Numero 18/1, 2017, Pagina/e 133: 1-6, ISSN 1471-2105
Editore: BioMed Central
DOI: 10.1186/s12859-017-1549-4

Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel

Autori: Theo de Witte, David Bowen, Marie Robin, Luca Malcovati, Dietger Niederwieser, Ibrahim Yakoub-Agha, Ghulam J. Mufti, Pierre Fenaux, Guillermo Sanz, Rodrigo Martino, Emilio Paolo Alessandrino, Francesco Onida, Argiris Symeonidis, Jakob Passweg, Guido Kobbe, Arnold Ganser, Uwe Platzbecker, Jürgen Finke, Michel van Gelder, Arjan A. van de Loosdrecht, Per Ljungman, Reinhard Stauder, Liisa Volin, H. J
Pubblicato in: Blood, Numero 129/13, 2017, Pagina/e 1753-1762, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2016-06-724500

Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT

Autori: Gerbrig Berger, Leonie I. Kroeze, Theresia N. Koorenhof-Scheele, Aniek O. de Graaf, Kenichi Yoshida, Hiroo Ueno, Yuichi Shiraishi, Satoru Miyano, Eva van den Berg, Hein Schepers, Bert A. van der Reijden, Seishi Ogawa, Edo Vellenga, Joop H. Jansen
Pubblicato in: Blood, Numero 131/16, 2018, Pagina/e 1846-1857, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2017-09-805879

Autori: Reinhard Stauder, Ge Yu, Karin A. Koinig, Tim Bagguley, Pierre Fenaux, Argiris Symeonidis, Guillermo Sanz, Jaroslav Cermak, Moshe Mittelman, Eva Hellström-Lindberg, Saskia Langemeijer, Mette Skov Holm, Krzysztof Mądry, Luca Malcovati, Aurelia Tatic, Ulrich Germing, Aleksandar Savic, Corine van Marrewijk, Agnès Guerci-Bresler, Elisa Luño, Jackie Droste, Fabio Efficace, Alex Smith, David Bowen,
Pubblicato in: Leukemia, Numero 32/6, 2018, Pagina/e 1380-1392, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-018-0089-x

Clonal evolution in myelodysplastic syndromes

Autori: Pedro da Silva-Coelho, Leonie I. Kroeze, Kenichi Yoshida, Theresia N. Koorenhof-Scheele, Ruth Knops, Louis T. van de Locht, Aniek O. de Graaf, Marion Massop, Sarah Sandmann, Martin Dugas, Marian J. Stevens-Kroef, Jaroslav Cermak, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Theo de Witte, Nicole M. A. Blijlevens, Petra Muus, Gerwin Huls, Bert A. van der Reijden, Seishi Ogawa, Joo
Pubblicato in: Nature Communications, Numero 8, 2017, Pagina/e 15099, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/ncomms15099

Evaluating Variant Calling Tools for Non-Matched Next-Generation Sequencing Data

Autori: Sarah Sandmann, Aniek O. de Graaf, Mohsen Karimi, Bert A. van der Reijden, Eva Hellström-Lindberg, Joop H. Jansen, Martin Dugas
Pubblicato in: Scientific Reports, Numero 7, 2017, Pagina/e 43169, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep43169

VIPER: a web application for rapid expert review of variant calls

Autori: Marius Wöste, Martin Dugas
Pubblicato in: Bioinformatics, Numero 34/11, 2018, Pagina/e 1928-1929, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/bty022

Early platelet count kinetics has prognostic value in lower-risk myelodysplastic syndromes

Autori: Raphael Itzykson, Simon Crouch, Erica Travaglino, Alex Smith, Argiris Symeonidis, Eva Hellström-Lindberg, Guillermo Sanz, Jaroslav Čermák, Reinhard Stauder, Chiara Elena, Ulrich Germing, Moshe Mittelman, Saskia Langemeijer, Krzysztof Mądry, Aurelia Tatic, Mette Skov Holm, Antonio Medina Almeida, Aleksandar Savic, Njetočka Gredelj Šimec, Elisa Luño, Dominic Culligan, Agnes Guerci-Bresler, Lu
Pubblicato in: Blood Advances, Numero 2/16, 2018, Pagina/e 2079-2089, ISSN 2473-9529
Editore: American Society of Hematology
DOI: 10.1182/bloodadvances.2018020495

Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome

Autori: H. K. G. Garelius, W. T. Johnston, A. G. Smith, S. Park, L. de Swart, P. Fenaux, A. Symeonidis, G. Sanz, J. Čermák, R. Stauder, L. Malcovati, M. Mittelman, A. A. van de Loosdrecht, C. J. van Marrewijk, D. Bowen, S. Crouch, T. J. M. de Witte, E. Hellström-Lindberg
Pubblicato in: Journal of Internal Medicine, Numero 281/3, 2016, Pagina/e 284-299, ISSN 0954-6820
Editore: Blackwell Publishing Inc.
DOI: 10.1111/joim.12579

appreci8: a pipeline for precise variant calling integrating 8 tools

Autori: Sarah Sandmann, Mohsen Karimi, Aniek O de Graaf, Christian Rohde, Stefanie Göllner, Julian Varghese, Jan Ernsting, Gunilla Walldin, Bert A van der Reijden, Carsten Müller-Tidow, Luca Malcovati, Eva Hellström-Lindberg, Joop H Jansen, Martin Dugas
Pubblicato in: Bioinformatics, Numero 34/24, 2018, Pagina/e 4205-4212, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/bty518

ODM Data Analysis—A tool for the automatic validation, monitoring and generation of generic descriptive statistics of patient data

Autori: Tobias Johannes Brix, Philipp Bruland, Saad Sarfraz, Jan Ernsting, Philipp Neuhaus, Michael Storck, Justin Doods, Sonja Ständer, Martin Dugas
Pubblicato in: PLOS ONE, Numero 13/6, 2018, Pagina/e e0199242, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0199242

Association of anemia with health-related quality of life and survival: a large population-based cohort study

Autori: Hanneke J.C.M. Wouters, Melanie M. van der Klauw, Theo de Witte, Reinhard Stauder, Dorine W. Swinkels, Bruce H.R. Wolffenbuttel, Gerwin Huls
Pubblicato in: Haematologica, Numero 104/3, 2019, Pagina/e 468-476, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.195552

Multidisciplinary care in the hematology clinic: Implementation of geriatric oncology

Autori: Valentin Goede, Reinhard Stauder
Pubblicato in: Journal of Geriatric Oncology, Numero 10/3, 2019, Pagina/e 497-503, ISSN 1879-4068
Editore: Elsevier BV
DOI: 10.1016/j.jgo.2018.09.003

Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals

Autori: Isabelle A. van Zeventer, Aniek O. de Graaf, Hanneke JCM Wouters, Bert A. Van der Reijden, Melanie van der Klauw, Theo M de Witte, Marianne A. Jonker, Luca Malcovati, Joop H Jansen, Geert Huls
Pubblicato in: Blood, Numero 135(14), 2020, Pagina/e 1161-1170, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood.2019004362

AMLVaran: a software approach to implement variant analysis of targeted NGS sequencing data in an oncological care setting

Autori: Christian Wünsch, Henrik Banck, Carsten Müller-Tidow, Martin Dugas
Pubblicato in: BMC Medical Genomics, Numero 13/1, 2020, ISSN 1755-8794
Editore: BioMed Central
DOI: 10.1186/s12920-020-0668-3

Myelodysplastic syndromes: moving towards personalized management

Autori: Eva Hellström-Lindberg, Magnus Tobiasson, Peter Greenberg
Pubblicato in: Haematologica, Numero 105/7, 2020, Pagina/e 1765-1779, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2020.248955

Algorithm using clinical and lab parameters may assist in ruling out and in diagnosing MDS

Autori: Oster HS, Crouch S, Smith A, Yu G, Abu Shrkihe B, Baruch S, Kolomansky A, Ben-Ezra J, Naor S, Fenaux P, Symeonidis A, Stauder R, Čermák J, Sanz G, Hellström-Lindberg E, Malcovati L, Langemeijer S, Germing U, Holm MS, Madry K, Guerci-Bresler A, Culligan D, Sanhes L, Mills J, Kotsianidis I, van Marrewijk C, Bowen D, de Witte T and Mittelman M
Pubblicato in: Blood Advances, Numero (accepted for publication), 2020, ISSN 0887-6924
Editore: Nature Publishing Group

Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome

Autori: Marlijn Hoeks, Tim Bagguley, Corine van Marrewijk, Alex Smith, David Bowen, Dominic Culligan, Seye Kolade, Argiris Symeonidis, Hege Garelius, Michail Spanoudakis, Saskia Langemeijer, Rian Roelofs, Erwin Wiegerinck, Aurelia Tatic, Sally Killick, Panagiotis Panagiotidis, Oana Stanca, Eva Hellström-Lindberg, Jaroslav Cermak, Melanie van der Klauw, Hanneke Wouters, Marian van Kraaij, Nicole Blijleven
Pubblicato in: Leukemia, Numero Sep 18. [Epub ahead of print], 2020, Pagina/e 2021 Jun;35(6):1745-1750 [jounal version], ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-020-01022-2

Novel dynamic outcome indicators and clinical endpoints in myelodysplastic syndrome; the European LeukemiaNet MDS Registry and MDS-RIGHT project perspective

Autori: Theo De Witte, Luca Malcovati, Pierre Fenaux, David Bowen, Argiris Symeonidis, Moshe Mittelman, Reinhard Stauder, Guillermo Sanz, Jaroslav Čermák, Saskia Langemeijer, Eva Hellström-Lindberg, Ulrich Germing, Mette Skov Holm, Krzysztof Mądry, Aurelia Tatic, António Medina Almeida, Aleksandar Savic, Inga Mandac Rogulj, Raphael Itzykson, Marlijn Hoeks, Hege Gravdahl Garelius, Dominic Culligan, Io
Pubblicato in: Haematologica, Numero 105/11, 2020, Pagina/e 2516-2523, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2020.266817

Core Set of Patient-Reported Outcomes for Myelodysplastic Syndromes - EUMDS Delphi Study in Patients and Hematologists

Autori: Igor Stojkov, Annette Conrads-Frank, Ursula Rochau, Karin A. Koinig, Marjan Arvandi, Sibylle Puntscher, Corine van Marrewijk, Pierre Fenaux, Argiris Symeonidis, Fatiha Chermat, Hege Garelius, David Bowen, Moshe Mittelman, Elvira Mora, Theo de Witte, Fabio Efficace, MD, Uwe Siebert, Reinhard Stauder
Pubblicato in: Blood Advances, Numero (under peer-review - revision invited), 2020, ISSN 0006-4971
Editore: American Society of Hematology

Comparison of Open-access Databases for Clinical Variant Interpretation in Cancer: A Case Study of MDS/AML

Autori: HENRIK BANCK, MARTIN DUGAS, CARSTEN MÜLLER-TIDOW, SARAH SANDMANN
Pubblicato in: Cancer Genomics - Proteomics, Numero 18/2, 2021, Pagina/e 157-166, ISSN 1109-6535
Editore: International Institute of Anticancer Research
DOI: 10.21873/cgp.20250

Computational analysis of flow cytometry data in hematological malignancies: future clinical practice?

Autori: Carolien Duetz, Costa Bachas, Theresia M. Westers, Arjan A. van de Loosdrecht
Pubblicato in: Current Opinion in Oncology, Numero 32/2, 2020, Pagina/e 162-169, ISSN 1040-8746
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/cco.0000000000000607

Impact of treatment with iron chelation therapy in patients with lower-risk myelodysplastic syndromes participating in the European MDS registry

Autori: Marlijn Hoeks, Ge Yu, Saskia Langemeijer, Simon Crouch, Louise de Swart, Pierre Fenaux, Argiris Symeonidis, Jaroslav Čermák, Eva Hellström-Lindberg, Guillermo Sanz, Reinhard Stauder, Mette Skov Holm, Moshe Mittelman, Krzysztof Mądry, Luca Malcovati, Aurelia Tatic, Antonio Medina Almeida, Ulrich Germing, Aleksandar Savic, Njetočka Gredelj Šimec, Dominic Culligan, Raphael Itzykson, Agnes Guerc
Pubblicato in: Haematologica, Numero 105/3, 2020, Pagina/e 640-651, ISSN 0390-6078
Editore: Ferrata Storti Foundation
DOI: 10.3324/haematol.2018.212332

Development of a core outcome set for myelodysplastic syndromes – a Delphi study from the EUMDS Registry Group

Autori: Ursula Rochau, Igor Stojkov, Annette Conrads‐Frank, Helena H. Borba, Karin A. Koinig, Marjan Arvandi, Corine Marrewijk, Hege Garelius, Ulrich Germing, Argiris Symeonidis, Guillermo F. Sanz, Pierre Fenaux, Theo Witte, Fabio Efficace, Uwe Siebert, Reinhard Stauder
Pubblicato in: British Journal of Haematology, Numero 191/3, 2020, Pagina/e 405-417, ISSN 0007-1048
Editore: Blackwell Publishing Inc.
DOI: 10.1111/bjh.16654

Myelodysplastisch syndroom

Autori: van de Loostdrecht AA
Pubblicato in: Nederlands Tijdschrift voor Hematologie [In Dutch], Numero DHC special April, 2020, ISSN 1572-1590
Editore: Ariez B.V.

Mutatiespectrum en dynamiek van klonale hematopoëse bij ouderen met anemie

Autori: van Zeventer, I
Pubblicato in: Nederlands Tijdschrift voor Hematologie [In Dutch], Numero DHC special April, 2020, ISSN 1572-1590
Editore: Ariez B.V.

IJzerchelatie bij laag-risico myelodysplsie

Autori: Langemeijer S (& Hoeks M)
Pubblicato in: Nederlands Tijdschrift voor Hematologie, Numero DHC special April 2018, 2018, Pagina/e 18-19, ISSN 1572-1590
Editore: Ariez B.V.

MDS: de juiste zorg op het juiste moment - MDS is een complexe en relatief zeldzame ziekte, maar het aantal patiënten groeit. Het project MDS-RIGHT heeft tot doel de zorg voor MDS-patiënten te verbeteren. Op welke manier?

Autori: de Witte, T (Gal M)
Pubblicato in: HEMATON [In Dutch], Numero Magazine 16 Winter 2017, 2017, Pagina/e 28-31
Editore: Stichting Hematon

Immuunfenotype als voorspeller voor pregressie bij MDS

Autori: van Spronsen M
Pubblicato in: Nederlands Tijdschrift voor Hematologie [In Dutch], Numero DHC special April, 2018, Pagina/e 11, ISSN 1572-1590
Editore: Ariez B.V.

Anemie en kwaliteit van leven

Autori: Wouters HJCM
Pubblicato in: Nederlands Tijdschrift voor Hematologie [In Dutch], Numero DHC special April, 2018, Pagina/e 12, ISSN 1572-1590
Editore: Ariez B.V.

Moleculaire Diagnostiek

Autori: Jansen J
Pubblicato in: Nederlands Tijdschrift voor Hematologie [In Dutch], Numero DHC special April, 2018, Pagina/e 54, ISSN 1572-1590
Editore: Ariez B.V.

Patiënten met laagrisico-MDS: met het oog op ijzergerelateerde problematiek

Autori: de Swart L
Pubblicato in: Medidact – Hematlogie [In Dutch], Numero Augustus vol. 4 / nr. 4, 2019, Pagina/e 18
Editore: unknown

De nieuwste ontwikkelingen op het gebied van ijzerstapeling bij myelodysplastisch syndroom

Autori: Hoeks M, Zwaginga JJ
Pubblicato in: Hematologie Actueel [In Dutch], Numero Jaargang 19 | nr. 2 | september 2019 [In Dutch], 2019
Editore: Academic Pharmaceutical Productions bv

Red blood cell transfusions in hemato-oncological patients - Don't iron out the consequences

Autori: Marlijn Hoeks, MD
Pubblicato in: Numero 3 November, 2020, ISBN 978-94-6421-027-9
Editore: Ipskamp Printing

The mutational landscape and microenvironment in Myelodysplastic Syndromes with deletion of chromosome 5q

Autori: Christian Scharenberg, MD
Pubblicato in: Numero 2 March, 2018, ISBN 978-91-7676-985-0
Editore: Karolinska Institutet

Registry studies on myelodysplastic syndrome and secondary acute myeloid leukemia

Autori: Hege Garelius, MD
Pubblicato in: Numero 4 May, 2018, ISBN 978-91-629-0488-3
Editore: BrandFactory

Patients with lower-risk myelodysplastic syndromes: in scope of iron related complications

Autori: Louise de Swart
Pubblicato in: Numero 12 June, 2019, ISBN 978-94-6380-330-4
Editore: ProefschriftMaken.nl

Translational regulations in normal and pathological erythropoiesis

Autori: Ismael Boussaid
Pubblicato in: UNIVERSITÉ DE PARIS, 2020
Editore: HAL OPEN SCIENCE

The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies [Internet]

Autori: Robin M, de Witte T. Myelodysplastic Syndromes. In: Carreras E, Dufour C, Mohty M, Kröger N, editors.
Pubblicato in: The EBMT Handbook, 7th ed., Numero Chapter 73, 2019
Editore: Springer

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