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PARAGONE: vaccines for animal parasites

Resultado final

PARAGONE website established

Website designed mounted on the WWW and publicised Work to be led by the 5M publishing arm of BAHL

F. hepatica phenotypes

A bank of Fasciola hepatica phenotypes will be established and the stocks held at QUB

Immunological Tools Workshop

A three day workshop will be held in ULPGC on the subject of immunological tools and livestock models of infection This will be open to PhD and postDocs from across the consortium as well as to young scientists from other relevant laboratories working on ruminant vaccinology A small number of scholarships will be available to facilitate travel and attendance of the workshop participants

Stakeholder Meeting III: Stakeholders' Input to Prototype Development

This Stakeholders View meeting will take place in ULPGC and will be an interface meeting of partner scientists from across the consortium with farmers and veterinarians to discuss the pros and cons of vaccination versus chemical treatment of parasites Feedback from this meeting will be used to help inform product design a focus of WP4 Demonstration

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Publicaciones

Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans

Autores: Andres Garcia-Campos, Alessandra Ravidà, D. Linh Nguyen, Krystyna Cwiklinski, John P. Dalton, Cornelis H. Hokke, Sandra O’Neill, Grace Mulcahy
Publicado en: PLOS Neglected Tropical Diseases, 10/5, 2016, Page(s) e0004688, ISSN 1935-2735
Editor: PLOS
DOI: 10.1371/journal.pntd.0004688

Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica

Autores: Maria Teresa Ruiz-Campillo, Veronica Molina Hernandez, Alejandro Escamilla, Michael Stevenson, Jose Perez, Alvaro Martinez-Moreno, Sheila Donnelly, John P. Dalton, Krystyna Cwiklinski
Publicado en: Scientific Reports, 7/1, 2017, Page(s) 1-14, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-03094-0

Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica

Autores: A. Escamilla, R. Zafra, J. Pérez, T.N. McNeilly, I.L. Pacheco, L. Buffoni, F.J. Martínez-Moreno, V. Molina-Hernández, A. Martínez-Moreno
Publicado en: Veterinary Parasitology, 230, 2016, Page(s) 14-19, ISSN 0304-4017
Editor: Elsevier BV
DOI: 10.1016/j.vetpar.2016.10.020

Th1/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica

Autores: I.L. Pacheco, N. Abril, N. Morales-Prieto, M.J. Bautista, R. Zafra, A. Escamilla, M.T. Ruiz, A. Martínez-Moreno, J. Pérez
Publicado en: Veterinary Parasitology, 238, 2017, Page(s) 61-65, ISSN 0304-4017
Editor: Elsevier BV
DOI: 10.1016/j.vetpar.2017.03.022

Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep

Autores: A. Escamilla, R. Pérez-Caballero, R. Zafra, M.J. Bautista, I.L. Pacheco, M.T. Ruiz, M.S. Martínez-Cruz, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Publicado en: Veterinary Parasitology, 238, 2017, Page(s) 49-53, ISSN 0304-4017
Editor: Elsevier BV
DOI: 10.1016/j.vetpar.2017.03.015

Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host

Autores: Krystyna Cwiklinski, Heather Jewhurst, Paul McVeigh, Tara Barbour, Aaron G. Maule, Jose Tort, Sandra M. O'Neill, Mark W. Robinson, Sheila Donnelly, John P. Dalton
Publicado en: Molecular & Cellular Proteomics, 17/4, 2018, Page(s) 792-809, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.RA117.000445

Advances in Fasciola hepatica research using ‘omics’ technologies

Autores: Krystyna Cwiklinski, John P. Dalton
Publicado en: International Journal for Parasitology, 48/5, 2018, Page(s) 321-331, ISSN 0020-7519
Editor: Elsevier BV
DOI: 10.1016/j.ijpara.2017.12.001

Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica -infected and/or vaccinated cattle and identification of protective linear B-cell epitopes

Autores: Laura Garza-Cuartero, Thomas Geurden, Suman M. Mahan, John M. Hardham, John P. Dalton, Grace Mulcahy
Publicado en: Vaccine, 36/7, 2018, Page(s) 958-968, ISSN 0264-410X
Editor: Elsevier BV
DOI: 10.1016/j.vaccine.2018.01.020

The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity

Autores: Akane Tanaka, Venkata Sita Rama Raju Allam, Jennifer Simpson, Natalia Tiberti, Jenna Shiels, Joyce To, Maria Lund, Valery Combes, Sinead Weldon, Cliff Taggart, John P. Dalton, Simon Phipps, Maria B. Sukkar, Sheila Donnelly
Publicado en: Journal of Allergy and Clinical Immunology, 2018, ISSN 0091-6749
Editor: Mosby Inc.
DOI: 10.1016/j.jaci.2018.01.050

Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora

Autores: Ana González-Hernández, Jimmy Borloo, Iris Peelaers, Stijn Casaert, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Publicado en: International Journal for Parasitology, 48/1, 2018, Page(s) 41-49, ISSN 0020-7519
Editor: Elsevier BV
DOI: 10.1016/j.ijpara.2017.07.002

The immunoregulatory effects of co-infection with Fasciola hepatica : From bovine tuberculosis to Johne's disease

Autores: Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl
Publicado en: The Veterinary Journal, 222, 2017, Page(s) 9-16, ISSN 1090-0233
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.tvjl.2017.02.007

Migration of Fasciola hepatica newly excysted juveniles is inhibited by high-mannose and oligomannose-type N-glycan-binding lectins

Autores: ANDRES GARCIA-CAMPOS, ALAN W. BAIRD, GRACE MULCAHY
Publicado en: Parasitology, 144/13, 2017, Page(s) 1708-1717, ISSN 0031-1820
Editor: Cambridge University Press
DOI: 10.1017/S003118201700124X

Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response

Autores: L. Garza-Cuartero, J. O'Sullivan, A. Blanco, J. McNair, M. Welsh, R. J. Flynn, D. Williams, P. Diggle, J. Cassidy, G. Mulcahy
Publicado en: Parasite Immunology, 38/7, 2016, Page(s) 387-402, ISSN 0141-9838
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pim.12326

Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function

Autores: Yan Fu, John A. Browne, Kate Killick, Grace Mulcahy
Publicado en: Frontiers in Immunology, 8, 2017, ISSN 1664-3224
Editor: Frontiers
DOI: 10.3389/fimmu.2017.00485

Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response

Autores: Ana González-Hernández, Stefanie Van Coppernolle, Jimmy Borloo, Frederik Van Meulder, Oonagh Paerewijck, Iris Peelaers, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Publicado en: Scientific Reports, 6, 2016, Page(s) 29496, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep29496

Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep

Autores: A. Escamilla, M.J. Bautista, R. Zafra, I.L. Pacheco, M.T. Ruiz, S. Martínez-Cruz, A. Méndez, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Publicado en: Veterinary Parasitology, 216, 2016, Page(s) 84-88, ISSN 0304-4017
Editor: Elsevier BV
DOI: 10.1016/j.vetpar.2015.12.013

Impeding movement of the poultry red mite, Dermanyssus gallinae

Autores: James Pritchard, Tatiana Küster, David George, Olivier Sparagano, Fiona Tomley
Publicado en: Veterinary Parasitology, 225, 2016, Page(s) 104-107, ISSN 0304-4017
Editor: Elsevier BV
DOI: 10.1016/j.vetpar.2016.06.006

Fasciolosis in South America: epidemiology and control challenges

Autores: C. Carmona, J.F. Tort
Publicado en: Journal of Helminthology, 2016, Page(s) 1-11, ISSN 0022-149X
Editor: CABI Publishing
DOI: 10.1017/S0022149X16000560

Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection

Autores: Yan Fu, Andreas L. Chryssafidis, John A. Browne, Jack O'Sullivan, Paul A. McGettigan, Grace Mulcahy
Publicado en: PLOS Neglected Tropical Diseases, 10/9, 2016, Page(s) e0005015, ISSN 1935-2735
Editor: PLOS
DOI: 10.1371/journal.pntd.0005015

Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants

Autores: Matthews JB, Geldhof P, Tzelos T, Claerebout E
Publicado en: Parasite Immunol., 10/12, 2016, ISSN 1365-3024
Editor: Blackwell
DOI: 10.1111/pim.12391

Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host

Autores: Alessandra Ravidà, Krystyna Cwiklinski, Allison M. Aldridge, Paul Clarke, Roisin Thompson, Jared Q. Gerlach, Michelle Kilcoyne, Cornelis H. Hokke, John P. Dalton, Sandra M. O'Neill
Publicado en: Molecular & Cellular Proteomics, 15/10, 2016, Page(s) 3139-3153, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.M116.059774

Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor

Autores: Alessandra Ravidà, Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill
Publicado en: PLOS Neglected Tropical Diseases, 10/4, 2016, Page(s) e0004601, ISSN 1935-2735
Editor: Plos
DOI: 10.1371/journal.pntd.0004601

A prospective view of animal and human Fasciolosis

Autores: K. Cwiklinski, S. M. O'Neill, S. Donnelly, J. P. Dalton
Publicado en: Parasite Immunology, 38/9, 2016, Page(s) 558-568, ISSN 0141-9838
Editor: Blackwell Publishing Inc.
DOI: 10.1111/pim.12343

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica : Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis

Autores: Krystyna Cwiklinski, Eduardo de la Torre-Escudero, Maria Trelis, Dolores Bernal, Philippe J. Dufresne, Gerard P. Brennan, Sandra O'Neill, Jose Tort, Steve Paterson, Antonio Marcilla, John P. Dalton, Mark W. Robinson
Publicado en: Molecular & Cellular Proteomics, 14/12, 2015, Page(s) 3258-3273, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.M115.053934

Unexpected Activity of a Novel Kunitz-type Inhibitor

Autores: David Smith, Irina G. Tikhonova, Heather L. Jewhurst, Orla C. Drysdale, Jan Dvořák, Mark W. Robinson, Krystyna Cwiklinski, John P. Dalton
Publicado en: Journal of Biological Chemistry, 291/37, 2016, Page(s) 19220-19234, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.M116.724344

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

Autores: R. Alvarado, J. To, M. E. Lund, A. Pinar, A. Mansell, M. W. Robinson, B. A. OBrien, J. P. Dalton, S. Donnelly
Publicado en: The FASEB Journal, 28/09/2016, 2016, Page(s) 1 - 11, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201500093R

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

Autores: Maria E. Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T. Hutchinson, Mark W. Robinson, Ann M. Simpson, Bronwyn A. O’Brien, John P. Dalton, Sheila Donnelly
Publicado en: Scientific Reports, 6, 2016, Page(s) 37789, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep37789

The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta

Autores: Alasdair J. Nisbet, Tom N. McNeilly, Daniel R.G. Price, E. Margaret Oliver, Yvonne Bartley, Mairi Mitchell, Javier Palarea-Albaladejo, Jacqueline B. Matthews
Publicado en: International Journal for Parasitology, 49/3-4, 2019, Page(s) 257-265, ISSN 0020-7519
Editor: Elsevier BV
DOI: 10.1016/j.ijpara.2018.10.006

Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica

Autores: I. L. Pacheco, N. Abril, R. Zafra, N. Morales-Prieto, V. Molina Hernández, M. T. Ruiz, R. Perez-Caballero, A. Martínez-Moreno, J. Pérez
Publicado en: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-37672-7

Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection

Autores: Raúl Pérez-Caballero, Leandro Buffoni, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, José Pérez, Álvaro Martínez-Moreno
Publicado en: Parasites & Vectors, 11/1, 2018, ISSN 1756-3305
Editor: BioMed Central
DOI: 10.1186/s13071-018-3072-5

Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis

Autores: Raúl Pérez-Caballero, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, Isabel L. Pacheco, M. Teresa Ruiz-Campillo, Alejandro Escamilla, José Pérez, Álvaro Martínez-Moreno, Leandro Buffoni
Publicado en: Parasites & Vectors, 11/1, 2018, ISSN 1756-3305
Editor: BioMed Central
DOI: 10.1186/s13071-018-3250-5

Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization

Autores: Maria Fernanda Dominguez, Javier González-Miguel, Carlos Carmona, John P. Dalton, Krystyna Cwiklinski, José Tort, Mar Siles-Lucas
Publicado en: Veterinary Parasitology, 258, 2018, Page(s) 46-52, ISSN 0304-4017
Editor: Elsevier BV
DOI: 10.1016/j.vetpar.2018.06.011

Impacts of breed type and vaccination on Teladorsagia circumcincta infection in native sheep in Gran Canaria

Autores: Jorge F. González, Julia N. Hernández, Cynthia Machín, Tara Pérez-Hernández, Harry W. Wright, Yolanda Corripio-Miyar, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet
Publicado en: Veterinary Research, 50/1, 2019, Page(s) 1-7, ISSN 1297-9716
Editor: SpringerNature
DOI: 10.1186/s13567-019-0646-y