Risultati finali Websites, patent fillings, videos etc. (1) PARAGONE website established Website designed mounted on the WWW and publicised Work to be led by the 5M publishing arm of BAHL Documents, reports (3) F. hepatica phenotypes A bank of Fasciola hepatica phenotypes will be established and the stocks held at QUB Immunological Tools Workshop A three day workshop will be held in ULPGC on the subject of immunological tools and livestock models of infection This will be open to PhD and postDocs from across the consortium as well as to young scientists from other relevant laboratories working on ruminant vaccinology A small number of scholarships will be available to facilitate travel and attendance of the workshop participants Stakeholder Meeting III: Stakeholders' Input to Prototype Development This Stakeholders View meeting will take place in ULPGC and will be an interface meeting of partner scientists from across the consortium with farmers and veterinarians to discuss the pros and cons of vaccination versus chemical treatment of parasites Feedback from this meeting will be used to help inform product design a focus of WP4 Demonstration Pubblicazioni Peer reviewed articles (33) Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans Autori: Andres Garcia-Campos, Alessandra Ravidà, D. Linh Nguyen, Krystyna Cwiklinski, John P. Dalton, Cornelis H. Hokke, Sandra O’Neill, Grace Mulcahy Pubblicato in: PLOS Neglected Tropical Diseases, Issue 10/5, 2016, Page(s) e0004688, ISSN 1935-2735 Editore: PLOS DOI: 10.1371/journal.pntd.0004688 Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica Autori: Maria Teresa Ruiz-Campillo, Veronica Molina Hernandez, Alejandro Escamilla, Michael Stevenson, Jose Perez, Alvaro Martinez-Moreno, Sheila Donnelly, John P. Dalton, Krystyna Cwiklinski Pubblicato in: Scientific Reports, Issue 7/1, 2017, Page(s) 1-14, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/s41598-017-03094-0 Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica Autori: A. Escamilla, R. Zafra, J. Pérez, T.N. McNeilly, I.L. Pacheco, L. Buffoni, F.J. Martínez-Moreno, V. Molina-Hernández, A. Martínez-Moreno Pubblicato in: Veterinary Parasitology, Issue 230, 2016, Page(s) 14-19, ISSN 0304-4017 Editore: Elsevier BV DOI: 10.1016/j.vetpar.2016.10.020 Th1/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica Autori: I.L. Pacheco, N. Abril, N. Morales-Prieto, M.J. Bautista, R. Zafra, A. Escamilla, M.T. Ruiz, A. Martínez-Moreno, J. Pérez Pubblicato in: Veterinary Parasitology, Issue 238, 2017, Page(s) 61-65, ISSN 0304-4017 Editore: Elsevier BV DOI: 10.1016/j.vetpar.2017.03.022 Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep Autori: A. Escamilla, R. Pérez-Caballero, R. Zafra, M.J. Bautista, I.L. Pacheco, M.T. Ruiz, M.S. Martínez-Cruz, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez Pubblicato in: Veterinary Parasitology, Issue 238, 2017, Page(s) 49-53, ISSN 0304-4017 Editore: Elsevier BV DOI: 10.1016/j.vetpar.2017.03.015 Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host Autori: Krystyna Cwiklinski, Heather Jewhurst, Paul McVeigh, Tara Barbour, Aaron G. Maule, Jose Tort, Sandra M. O'Neill, Mark W. Robinson, Sheila Donnelly, John P. Dalton Pubblicato in: Molecular & Cellular Proteomics, Issue 17/4, 2018, Page(s) 792-809, ISSN 1535-9476 Editore: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/mcp.RA117.000445 Advances in Fasciola hepatica research using ‘omics’ technologies Autori: Krystyna Cwiklinski, John P. Dalton Pubblicato in: International Journal for Parasitology, Issue 48/5, 2018, Page(s) 321-331, ISSN 0020-7519 Editore: Elsevier BV DOI: 10.1016/j.ijpara.2017.12.001 Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica -infected and/or vaccinated cattle and identification of protective linear B-cell epitopes Autori: Laura Garza-Cuartero, Thomas Geurden, Suman M. Mahan, John M. Hardham, John P. Dalton, Grace Mulcahy Pubblicato in: Vaccine, Issue 36/7, 2018, Page(s) 958-968, ISSN 0264-410X Editore: Elsevier BV DOI: 10.1016/j.vaccine.2018.01.020 The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity Autori: Akane Tanaka, Venkata Sita Rama Raju Allam, Jennifer Simpson, Natalia Tiberti, Jenna Shiels, Joyce To, Maria Lund, Valery Combes, Sinead Weldon, Cliff Taggart, John P. Dalton, Simon Phipps, Maria B. Sukkar, Sheila Donnelly Pubblicato in: Journal of Allergy and Clinical Immunology, 2018, ISSN 0091-6749 Editore: Mosby Inc. DOI: 10.1016/j.jaci.2018.01.050 Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora Autori: Ana González-Hernández, Jimmy Borloo, Iris Peelaers, Stijn Casaert, Georges Leclercq, Edwin Claerebout, Peter Geldhof Pubblicato in: International Journal for Parasitology, Issue 48/1, 2018, Page(s) 41-49, ISSN 0020-7519 Editore: Elsevier BV DOI: 10.1016/j.ijpara.2017.07.002 The immunoregulatory effects of co-infection with Fasciola hepatica : From bovine tuberculosis to Johne's disease Autori: Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl Pubblicato in: The Veterinary Journal, Issue 222, 2017, Page(s) 9-16, ISSN 1090-0233 Editore: W. B. Saunders Co., Ltd. DOI: 10.1016/j.tvjl.2017.02.007 Migration of Fasciola hepatica newly excysted juveniles is inhibited by high-mannose and oligomannose-type N-glycan-binding lectins Autori: ANDRES GARCIA-CAMPOS, ALAN W. BAIRD, GRACE MULCAHY Pubblicato in: Parasitology, Issue 144/13, 2017, Page(s) 1708-1717, ISSN 0031-1820 Editore: Cambridge University Press DOI: 10.1017/S003118201700124X Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response Autori: L. Garza-Cuartero, J. O'Sullivan, A. Blanco, J. McNair, M. Welsh, R. J. Flynn, D. Williams, P. Diggle, J. Cassidy, G. Mulcahy Pubblicato in: Parasite Immunology, Issue 38/7, 2016, Page(s) 387-402, ISSN 0141-9838 Editore: Blackwell Publishing Inc. DOI: 10.1111/pim.12326 Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function Autori: Yan Fu, John A. Browne, Kate Killick, Grace Mulcahy Pubblicato in: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224 Editore: Frontiers DOI: 10.3389/fimmu.2017.00485 Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response Autori: Ana González-Hernández, Stefanie Van Coppernolle, Jimmy Borloo, Frederik Van Meulder, Oonagh Paerewijck, Iris Peelaers, Georges Leclercq, Edwin Claerebout, Peter Geldhof Pubblicato in: Scientific Reports, Issue 6, 2016, Page(s) 29496, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/srep29496 Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep Autori: A. Escamilla, M.J. Bautista, R. Zafra, I.L. Pacheco, M.T. Ruiz, S. Martínez-Cruz, A. Méndez, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez Pubblicato in: Veterinary Parasitology, Issue 216, 2016, Page(s) 84-88, ISSN 0304-4017 Editore: Elsevier BV DOI: 10.1016/j.vetpar.2015.12.013 Impeding movement of the poultry red mite, Dermanyssus gallinae Autori: James Pritchard, Tatiana Küster, David George, Olivier Sparagano, Fiona Tomley Pubblicato in: Veterinary Parasitology, Issue 225, 2016, Page(s) 104-107, ISSN 0304-4017 Editore: Elsevier BV DOI: 10.1016/j.vetpar.2016.06.006 Fasciolosis in South America: epidemiology and control challenges Autori: C. Carmona, J.F. Tort Pubblicato in: Journal of Helminthology, 2016, Page(s) 1-11, ISSN 0022-149X Editore: CABI Publishing DOI: 10.1017/S0022149X16000560 Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection Autori: Yan Fu, Andreas L. Chryssafidis, John A. Browne, Jack O'Sullivan, Paul A. McGettigan, Grace Mulcahy Pubblicato in: PLOS Neglected Tropical Diseases, Issue 10/9, 2016, Page(s) e0005015, ISSN 1935-2735 Editore: PLOS DOI: 10.1371/journal.pntd.0005015 Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants Autori: Matthews JB, Geldhof P, Tzelos T, Claerebout E Pubblicato in: Parasite Immunol., Issue 10/12, 2016, ISSN 1365-3024 Editore: Blackwell DOI: 10.1111/pim.12391 Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host Autori: Alessandra Ravidà, Krystyna Cwiklinski, Allison M. Aldridge, Paul Clarke, Roisin Thompson, Jared Q. Gerlach, Michelle Kilcoyne, Cornelis H. Hokke, John P. Dalton, Sandra M. O'Neill Pubblicato in: Molecular & Cellular Proteomics, Issue 15/10, 2016, Page(s) 3139-3153, ISSN 1535-9476 Editore: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/mcp.M116.059774 Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor Autori: Alessandra Ravidà, Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill Pubblicato in: PLOS Neglected Tropical Diseases, Issue 10/4, 2016, Page(s) e0004601, ISSN 1935-2735 Editore: Plos DOI: 10.1371/journal.pntd.0004601 A prospective view of animal and human Fasciolosis Autori: K. Cwiklinski, S. M. O'Neill, S. Donnelly, J. P. Dalton Pubblicato in: Parasite Immunology, Issue 38/9, 2016, Page(s) 558-568, ISSN 0141-9838 Editore: Blackwell Publishing Inc. DOI: 10.1111/pim.12343 The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica : Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis Autori: Krystyna Cwiklinski, Eduardo de la Torre-Escudero, Maria Trelis, Dolores Bernal, Philippe J. Dufresne, Gerard P. Brennan, Sandra O'Neill, Jose Tort, Steve Paterson, Antonio Marcilla, John P. Dalton, Mark W. Robinson Pubblicato in: Molecular & Cellular Proteomics, Issue 14/12, 2015, Page(s) 3258-3273, ISSN 1535-9476 Editore: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/mcp.M115.053934 Unexpected Activity of a Novel Kunitz-type Inhibitor Autori: David Smith, Irina G. Tikhonova, Heather L. Jewhurst, Orla C. Drysdale, Jan Dvořák, Mark W. Robinson, Krystyna Cwiklinski, John P. Dalton Pubblicato in: Journal of Biological Chemistry, Issue 291/37, 2016, Page(s) 19220-19234, ISSN 0021-9258 Editore: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.M116.724344 The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages Autori: R. Alvarado, J. To, M. E. Lund, A. Pinar, A. Mansell, M. W. Robinson, B. A. OBrien, J. P. Dalton, S. Donnelly Pubblicato in: The FASEB Journal, Issue 28/09/2016, 2016, Page(s) 1 - 11, ISSN 0892-6638 Editore: Federation of American Societies for Experimental Biology DOI: 10.1096/fj.201500093R A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis Autori: Maria E. Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T. Hutchinson, Mark W. Robinson, Ann M. Simpson, Bronwyn A. O’Brien, John P. Dalton, Sheila Donnelly Pubblicato in: Scientific Reports, Issue 6, 2016, Page(s) 37789, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/srep37789 The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta Autori: Alasdair J. Nisbet, Tom N. McNeilly, Daniel R.G. Price, E. Margaret Oliver, Yvonne Bartley, Mairi Mitchell, Javier Palarea-Albaladejo, Jacqueline B. Matthews Pubblicato in: International Journal for Parasitology, Issue 49/3-4, 2019, Page(s) 257-265, ISSN 0020-7519 Editore: Elsevier BV DOI: 10.1016/j.ijpara.2018.10.006 Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica Autori: I. L. Pacheco, N. Abril, R. Zafra, N. Morales-Prieto, V. Molina Hernández, M. T. Ruiz, R. Perez-Caballero, A. Martínez-Moreno, J. Pérez Pubblicato in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322 Editore: Nature Publishing Group DOI: 10.1038/s41598-018-37672-7 Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection Autori: Raúl Pérez-Caballero, Leandro Buffoni, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, José Pérez, Álvaro Martínez-Moreno Pubblicato in: Parasites & Vectors, Issue 11/1, 2018, ISSN 1756-3305 Editore: BioMed Central DOI: 10.1186/s13071-018-3072-5 Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis Autori: Raúl Pérez-Caballero, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, Isabel L. Pacheco, M. Teresa Ruiz-Campillo, Alejandro Escamilla, José Pérez, Álvaro Martínez-Moreno, Leandro Buffoni Pubblicato in: Parasites & Vectors, Issue 11/1, 2018, ISSN 1756-3305 Editore: BioMed Central DOI: 10.1186/s13071-018-3250-5 Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization Autori: Maria Fernanda Dominguez, Javier González-Miguel, Carlos Carmona, John P. Dalton, Krystyna Cwiklinski, José Tort, Mar Siles-Lucas Pubblicato in: Veterinary Parasitology, Issue 258, 2018, Page(s) 46-52, ISSN 0304-4017 Editore: Elsevier BV DOI: 10.1016/j.vetpar.2018.06.011 Impacts of breed type and vaccination on Teladorsagia circumcincta infection in native sheep in Gran Canaria Autori: Jorge F. González, Julia N. Hernández, Cynthia Machín, Tara Pérez-Hernández, Harry W. Wright, Yolanda Corripio-Miyar, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet Pubblicato in: Veterinary Research, Issue 50/1, 2019, Page(s) 1-7, ISSN 1297-9716 Editore: SpringerNature DOI: 10.1186/s13567-019-0646-y È in corso la ricerca di dati su OpenAIRE... Si è verificato un errore durante la ricerca dei dati su OpenAIRE Nessun risultato disponibile
