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PARAGONE: vaccines for animal parasites

Rezultaty

PARAGONE website established

Website designed, mounted on the WWW and publicised. Work to be led by the 5M publishing arm of BAHL.

F. hepatica phenotypes

A bank of Fasciola hepatica phenotypes will be established and the stocks held at QUB

Immunological Tools Workshop

A three day workshop will be held in ULPGC on the subject of immunological tools and livestock models of infection. This will be open to PhD and post-Docs from across the consortium as well as to young scientists from other relevant laboratories working on ruminant vaccinology. A small number of scholarships will be available to facilitate travel and attendance of the workshop participants.

Stakeholder Meeting III: Stakeholders' Input to Prototype Development

This Stakeholders' View meeting will take place in ULPGC and will be an interface meeting of partner scientists from across the consortium with farmers and veterinarians to discuss the pros and cons of vaccination versus chemical treatment of parasites. Feedback from this meeting will be used to help inform product design, a focus of WP4 (Demonstration)

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Publikacje

Tegument Glycoproteins and Cathepsins of Newly Excysted Juvenile Fasciola hepatica Carry Mannosidic and Paucimannosidic N-glycans

Autorzy: Andres Garcia-Campos, Alessandra Ravidà, D. Linh Nguyen, Krystyna Cwiklinski, John P. Dalton, Cornelis H. Hokke, Sandra O’Neill, Grace Mulcahy
Opublikowane w: PLOS Neglected Tropical Diseases, Issue 10/5, 2016, Page(s) e0004688, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0004688

Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica

Autorzy: Maria Teresa Ruiz-Campillo, Veronica Molina Hernandez, Alejandro Escamilla, Michael Stevenson, Jose Perez, Alvaro Martinez-Moreno, Sheila Donnelly, John P. Dalton, Krystyna Cwiklinski
Opublikowane w: Scientific Reports, Issue 7/1, 2017, Page(s) 1-14, ISSN 2045-2322
DOI: 10.1038/s41598-017-03094-0

Distribution of Foxp3+ T cells in the liver and hepatic lymph nodes of goats and sheep experimentally infected with Fasciola hepatica

Autorzy: A. Escamilla, R. Zafra, J. Pérez, T.N. McNeilly, I.L. Pacheco, L. Buffoni, F.J. Martínez-Moreno, V. Molina-Hernández, A. Martínez-Moreno
Opublikowane w: Veterinary Parasitology, Issue 230, 2016, Page(s) 14-19, ISSN 0304-4017
DOI: 10.1016/j.vetpar.2016.10.020

Th1/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica

Autorzy: I.L. Pacheco, N. Abril, N. Morales-Prieto, M.J. Bautista, R. Zafra, A. Escamilla, M.T. Ruiz, A. Martínez-Moreno, J. Pérez
Opublikowane w: Veterinary Parasitology, Issue 238, 2017, Page(s) 61-65, ISSN 0304-4017
DOI: 10.1016/j.vetpar.2017.03.022

Apoptosis of peritoneal leucocytes during early stages of Fasciola hepatica infections in sheep

Autorzy: A. Escamilla, R. Pérez-Caballero, R. Zafra, M.J. Bautista, I.L. Pacheco, M.T. Ruiz, M.S. Martínez-Cruz, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Opublikowane w: Veterinary Parasitology, Issue 238, 2017, Page(s) 49-53, ISSN 0304-4017
DOI: 10.1016/j.vetpar.2017.03.015

Infection by the Helminth Parasite Fasciola hepatica Requires Rapid Regulation of Metabolic, Virulence, and Invasive Factors to Adjust to Its Mammalian Host

Autorzy: Krystyna Cwiklinski, Heather Jewhurst, Paul McVeigh, Tara Barbour, Aaron G. Maule, Jose Tort, Sandra M. O'Neill, Mark W. Robinson, Sheila Donnelly, John P. Dalton
Opublikowane w: Molecular & Cellular Proteomics, Issue 17/4, 2018, Page(s) 792-809, ISSN 1535-9476
DOI: 10.1074/mcp.RA117.000445

Advances in Fasciola hepatica research using ‘omics’ technologies

Autorzy: Krystyna Cwiklinski, John P. Dalton
Opublikowane w: International Journal for Parasitology, Issue 48/5, 2018, Page(s) 321-331, ISSN 0020-7519
DOI: 10.1016/j.ijpara.2017.12.001

Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica -infected and/or vaccinated cattle and identification of protective linear B-cell epitopes

Autorzy: Laura Garza-Cuartero, Thomas Geurden, Suman M. Mahan, John M. Hardham, John P. Dalton, Grace Mulcahy
Opublikowane w: Vaccine, Issue 36/7, 2018, Page(s) 958-968, ISSN 0264-410X
DOI: 10.1016/j.vaccine.2018.01.020

The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity

Autorzy: Akane Tanaka, Venkata Sita Rama Raju Allam, Jennifer Simpson, Natalia Tiberti, Jenna Shiels, Joyce To, Maria Lund, Valery Combes, Sinead Weldon, Cliff Taggart, John P. Dalton, Simon Phipps, Maria B. Sukkar, Sheila Donnelly
Opublikowane w: Journal of Allergy and Clinical Immunology, 2018, ISSN 0091-6749
DOI: 10.1016/j.jaci.2018.01.050

Comparative analysis of the immune responses induced by native versus recombinant versions of the ASP-based vaccine against the bovine intestinal parasite Cooperia oncophora

Autorzy: Ana González-Hernández, Jimmy Borloo, Iris Peelaers, Stijn Casaert, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Opublikowane w: International Journal for Parasitology, Issue 48/1, 2018, Page(s) 41-49, ISSN 0020-7519
DOI: 10.1016/j.ijpara.2017.07.002

The immunoregulatory effects of co-infection with Fasciola hepatica : From bovine tuberculosis to Johne's disease

Autorzy: Amalia Naranjo Lucena, Laura Garza Cuartero, Grace Mulcahy, Annetta Zintl
Opublikowane w: The Veterinary Journal, Issue 222, 2017, Page(s) 9-16, ISSN 1090-0233
DOI: 10.1016/j.tvjl.2017.02.007

Migration of Fasciola hepatica newly excysted juveniles is inhibited by high-mannose and oligomannose-type N-glycan-binding lectins

Autorzy: ANDRES GARCIA-CAMPOS, ALAN W. BAIRD, GRACE MULCAHY
Opublikowane w: Parasitology, Issue 144/13, 2017, Page(s) 1708-1717, ISSN 0031-1820
DOI: 10.1017/S003118201700124X

Fasciola hepatica infection reduces Mycobacterium bovis burden and mycobacterial uptake and suppresses the pro-inflammatory response

Autorzy: L. Garza-Cuartero, J. O'Sullivan, A. Blanco, J. McNair, M. Welsh, R. J. Flynn, D. Williams, P. Diggle, J. Cassidy, G. Mulcahy
Opublikowane w: Parasite Immunology, Issue 38/7, 2016, Page(s) 387-402, ISSN 0141-9838
DOI: 10.1111/pim.12326

Network Analysis of the Systemic Response to Fasciola hepatica Infection in Sheep Reveals Changes in Fibrosis, Apoptosis, Toll-Like Receptors 3/4, and B Cell Function

Autorzy: Yan Fu, John A. Browne, Kate Killick, Grace Mulcahy
Opublikowane w: Frontiers in Immunology, Issue 8, 2017, ISSN 1664-3224
DOI: 10.3389/fimmu.2017.00485

Host protective ASP-based vaccine against the parasitic nematode Ostertagia ostertagi triggers NK cell activation and mixed IgG1-IgG2 response

Autorzy: Ana González-Hernández, Stefanie Van Coppernolle, Jimmy Borloo, Frederik Van Meulder, Oonagh Paerewijck, Iris Peelaers, Georges Leclercq, Edwin Claerebout, Peter Geldhof
Opublikowane w: Scientific Reports, Issue 6, 2016, Page(s) 29496, ISSN 2045-2322
DOI: 10.1038/srep29496

Fasciola hepatica induces eosinophil apoptosis in the migratory and biliary stages of infection in sheep

Autorzy: A. Escamilla, M.J. Bautista, R. Zafra, I.L. Pacheco, M.T. Ruiz, S. Martínez-Cruz, A. Méndez, A. Martínez-Moreno, V. Molina-Hernández, J. Pérez
Opublikowane w: Veterinary Parasitology, Issue 216, 2016, Page(s) 84-88, ISSN 0304-4017
DOI: 10.1016/j.vetpar.2015.12.013

Impeding movement of the poultry red mite, Dermanyssus gallinae

Autorzy: James Pritchard, Tatiana Küster, David George, Olivier Sparagano, Fiona Tomley
Opublikowane w: Veterinary Parasitology, Issue 225, 2016, Page(s) 104-107, ISSN 0304-4017
DOI: 10.1016/j.vetpar.2016.06.006

Fasciolosis in South America: epidemiology and control challenges

Autorzy: C. Carmona, J.F. Tort
Opublikowane w: Journal of Helminthology, 2016, Page(s) 1-11, ISSN 0022-149X
DOI: 10.1017/S0022149X16000560

Transcriptomic Study on Ovine Immune Responses to Fasciola hepatica Infection

Autorzy: Yan Fu, Andreas L. Chryssafidis, John A. Browne, Jack O'Sullivan, Paul A. McGettigan, Grace Mulcahy
Opublikowane w: PLOS Neglected Tropical Diseases, Issue 10/9, 2016, Page(s) e0005015, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0005015

Progress in the development of subunit vaccines for gastrointestinal nematodes of ruminants

Autorzy: Matthews JB, Geldhof P, Tzelos T, Claerebout E
Opublikowane w: Parasite Immunol., Issue 10/12, 2016, ISSN 1365-3024
DOI: 10.1111/pim.12391

Fasciola hepatica Surface Tegument: Glycoproteins at the Interface of Parasite and Host

Autorzy: Alessandra Ravidà, Krystyna Cwiklinski, Allison M. Aldridge, Paul Clarke, Roisin Thompson, Jared Q. Gerlach, Michelle Kilcoyne, Cornelis H. Hokke, John P. Dalton, Sandra M. O'Neill
Opublikowane w: Molecular & Cellular Proteomics, Issue 15/10, 2016, Page(s) 3139-3153, ISSN 1535-9476
DOI: 10.1074/mcp.M116.059774

Fasciola hepatica Surface Coat Glycoproteins Contain Mannosylated and Phosphorylated N-glycans and Exhibit Immune Modulatory Properties Independent of the Mannose Receptor

Autorzy: Alessandra Ravidà, Allison M. Aldridge, Nicole N. Driessen, Ferry A. H. Heus, Cornelis H. Hokke, Sandra M. O’Neill
Opublikowane w: PLOS Neglected Tropical Diseases, Issue 10/4, 2016, Page(s) e0004601, ISSN 1935-2735
DOI: 10.1371/journal.pntd.0004601

A prospective view of animal and human Fasciolosis

Autorzy: K. Cwiklinski, S. M. O'Neill, S. Donnelly, J. P. Dalton
Opublikowane w: Parasite Immunology, Issue 38/9, 2016, Page(s) 558-568, ISSN 0141-9838
DOI: 10.1111/pim.12343

The Extracellular Vesicles of the Helminth Pathogen, Fasciola hepatica : Biogenesis Pathways and Cargo Molecules Involved in Parasite Pathogenesis

Autorzy: Krystyna Cwiklinski, Eduardo de la Torre-Escudero, Maria Trelis, Dolores Bernal, Philippe J. Dufresne, Gerard P. Brennan, Sandra O'Neill, Jose Tort, Steve Paterson, Antonio Marcilla, John P. Dalton, Mark W. Robinson
Opublikowane w: Molecular & Cellular Proteomics, Issue 14/12, 2015, Page(s) 3258-3273, ISSN 1535-9476
DOI: 10.1074/mcp.M115.053934

Unexpected Activity of a Novel Kunitz-type Inhibitor

Autorzy: David Smith, Irina G. Tikhonova, Heather L. Jewhurst, Orla C. Drysdale, Jan Dvořák, Mark W. Robinson, Krystyna Cwiklinski, John P. Dalton
Opublikowane w: Journal of Biological Chemistry, Issue 291/37, 2016, Page(s) 19220-19234, ISSN 0021-9258
DOI: 10.1074/jbc.M116.724344

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

Autorzy: R. Alvarado, J. To, M. E. Lund, A. Pinar, A. Mansell, M. W. Robinson, B. A. OBrien, J. P. Dalton, S. Donnelly
Opublikowane w: The FASEB Journal, Issue 28/09/2016, 2016, Page(s) 1 - 11, ISSN 0892-6638
DOI: 10.1096/fj.201500093R

A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis

Autorzy: Maria E. Lund, Judith Greer, Aakanksha Dixit, Raquel Alvarado, Padraig McCauley-Winter, Joyce To, Akane Tanaka, Andrew T. Hutchinson, Mark W. Robinson, Ann M. Simpson, Bronwyn A. O’Brien, John P. Dalton, Sheila Donnelly
Opublikowane w: Scientific Reports, Issue 6, 2016, Page(s) 37789, ISSN 2045-2322
DOI: 10.1038/srep37789

The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta

Autorzy: Alasdair J. Nisbet, Tom N. McNeilly, Daniel R.G. Price, E. Margaret Oliver, Yvonne Bartley, Mairi Mitchell, Javier Palarea-Albaladejo, Jacqueline B. Matthews
Opublikowane w: International Journal for Parasitology, Issue 49/3-4, 2019, Page(s) 257-265, ISSN 0020-7519
DOI: 10.1016/j.ijpara.2018.10.006

Identification of reference genes for real-time PCR cytokine gene expression studies in sheep experimentally infected with Fasciola hepatica

Autorzy: I. L. Pacheco, N. Abril, R. Zafra, N. Morales-Prieto, V. Molina Hernández, M. T. Ruiz, R. Perez-Caballero, A. Martínez-Moreno, J. Pérez
Opublikowane w: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
DOI: 10.1038/s41598-018-37672-7

Expression of free radicals by peritoneal cells of sheep during the early stages of Fasciola hepatica infection

Autorzy: Raúl Pérez-Caballero, Leandro Buffoni, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, José Pérez, Álvaro Martínez-Moreno
Opublikowane w: Parasites & Vectors, Issue 11/1, 2018, ISSN 1756-3305
DOI: 10.1186/s13071-018-3072-5

Comparative dynamics of peritoneal cell immunophenotypes in sheep during the early and late stages of the infection with Fasciola hepatica by flow cytometric analysis

Autorzy: Raúl Pérez-Caballero, F. Javier Martínez-Moreno, Rafael Zafra, Verónica Molina-Hernández, Isabel L. Pacheco, M. Teresa Ruiz-Campillo, Alejandro Escamilla, José Pérez, Álvaro Martínez-Moreno, Leandro Buffoni
Opublikowane w: Parasites & Vectors, Issue 11/1, 2018, ISSN 1756-3305
DOI: 10.1186/s13071-018-3250-5

Low allelic diversity in vaccine candidates genes from different locations sustain hope for Fasciola hepatica immunization

Autorzy: Maria Fernanda Dominguez, Javier González-Miguel, Carlos Carmona, John P. Dalton, Krystyna Cwiklinski, José Tort, Mar Siles-Lucas
Opublikowane w: Veterinary Parasitology, Issue 258, 2018, Page(s) 46-52, ISSN 0304-4017
DOI: 10.1016/j.vetpar.2018.06.011

Impacts of breed type and vaccination on Teladorsagia circumcincta infection in native sheep in Gran Canaria

Autorzy: Jorge F. González, Julia N. Hernández, Cynthia Machín, Tara Pérez-Hernández, Harry W. Wright, Yolanda Corripio-Miyar, Daniel R. G. Price, Jacqueline B. Matthews, Tom N. McNeilly, Alasdair J. Nisbet
Opublikowane w: Veterinary Research, Issue 50/1, 2019, Page(s) 1-7, ISSN 1297-9716
DOI: 10.1186/s13567-019-0646-y