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Growth factors and ovarian function in cattle. The IGF system and the oestrogen receptor

Ziel

Studies performed at the universities of Nottingham, Edinburgh and Aberdeen have identified the insulin/IGF systems as a major putative mediator of nutritional influences on reproduction as this system exerts both endocrine and locally mediated effects on ovarian folliculogenesis, oogenesis and embryogenesis. However, little is known about the down-stream mechanisms that allow this regulation. Bioavailability of IGF-I at the ovary could be a key factor through effects on follicular and oocyte growth in addition to positive effects on embryo development. Preliminary results obtained by the applicant during the tenure of the previous Marie Cure action would suggest that IGF-I stimulates numerous cellular activities on follicular cells, including ligand-independent activation of the beta-oestrogen receptor, which could be used as an indirect marker of fertility. The continuing decline in fertility over the last years has a major impact on sustainability of dairy production, and therefore has considerable social consequences. This project will continue the previous experiments performed by the applicant at the University of Nottingham under the supervision of Prof. Webb and Prof. Flint aiming to identify a key step by which dietary inputs, in direct relation to the IGF system, affect dairy cow fertility.

Wissenschaftliches Gebiet (EuroSciVoc)

Schlüsselbegriffe

Thema/Themen

Aufforderung zur Vorschlagseinreichung

FP6-2002-MOBILITY-11
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

ERG - Marie Curie actions-European Re-integration Grants

Koordinator

UNIVERSITAT AUTONOMA DE BARCELONA
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Campus Universitari
BELLATERRA (CERDANYOLA DEL VALLES)
Spanien
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