Defining how environmental factors influence downstream effects of immune-mediated disease risk-SNPs

Project Information

ImmRisk

Grant agreement ID: 637640

DOI 10.3030/637640

Project closed

EC signature date 13 May 2015

Start date 1 September 2015

End date 28 February 2021

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 496 690,00

EU contribution € 1 496 690,00

Coordinated by

ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands

Publications

Peer reviewed articles (8)

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Author(s): Urmo Võsa, Annique Claringbould, Harm-Jan Westra, Marc Jan Bonder, Patrick Deelen, Biao Zeng, Holger Kirsten, Ashis Saha, Roman Kreuzhuber, Seyhan Yazar, Harm Brugge, Roy Oelen, Dylan H. de Vries, Monique G. P. van der Wijst, Silva Kasela, Natalia Pervjakova, Isabel Alves, Marie-Julie Favé, Mawussé Agbessi, Mark W. Christiansen, Rick Jansen, Ilkka Seppälä, Lin Tong, Alexander Teumer, Katharin
Published in: Nature Genetics, Issue 53/9, 2021, Page(s) 1300-1310, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00913-z

Improving the diagnostic yield of exome- sequencing by predicting gene–phenotype associations using large-scale gene expression analysis

Author(s): Patrick Deelen, Sipko van Dam, Johanna C. Herkert, Juha M. Karjalainen, Harm Brugge, Kristin M. Abbott, Cleo C. van Diemen, Paul A. van der Zwaag, Erica H. Gerkes, Evelien Zonneveld-Huijssoon, Jelkje J. Boer-Bergsma, Pytrik Folkertsma, Tessa Gillett, K. Joeri van der Velde, Roan Kanninga, Peter C. van den Akker, Sabrina Z. Jan, Edgar T. Hoorntje, Wouter P. te Rijdt, Yvonne J. Vos, Jan D. H. Jongbl
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-10649-4

Translational insights from single-cell technologies across the cardiovascular disease continuum

Author(s): Irene V. van Blokland, Hilde E. Groot, Lude H. Franke, Monique G.P. van der Wijst, Pim van der Harst
Published in: Trends in Cardiovascular Medicine, 2021, ISSN 1050-1738
Publisher: Elsevier BV
DOI: 10.1016/j.tcm.2021.02.009

The single-cell eQTLGen consortium

Author(s): MGP van der Wijst, DH de Vries, HE Groot, G Trynka, CC Hon, MJ Bonder, O Stegle, MC Nawijn, Y Idaghdour, P van der Harst, CJ Ye, J Powell, FJ Theis, A Mahfouz, M Heinig, L Franke
Published in: eLife, Issue 9, 2020, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.52155

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

Author(s): Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra, Lude Franke
Published in: BMC Genomics, Issue 22/1, 2021, ISSN 1471-2164
Publisher: BioMed Central
DOI: 10.1186/s12864-020-07344-w

Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies

Author(s): Rocio Acuna-Hidalgo, Pelagia Deriziotis, Marloes Steehouwer, Christian Gilissen, Sarah A. Graham, Sipko van Dam, Julie Hoover-Fong, Aida B. Telegrafi, Anne Destree, Robert Smigiel, Lindsday A. Lambie, Hülya Kayserili, Umut Altunoglu, Elisabetta Lapi, Maria Luisa Uzielli, Mariana Aracena, Banu G. Nur, Ercan Mihci, Lilia M. A. Moreira, Viviane Borges Ferreira, Dafne D. G. Horovitz, Katia M. da Roch
Published in: PLOS Genetics, Issue 13/3, 2017, Page(s) e1006683, ISSN 1553-7404
Publisher: Public Library of Science
DOI: 10.1371/journal.pgen.1006683

Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs

Author(s): Monique G. P. van der Wijst, Harm Brugge, Dylan H. de Vries, Patrick Deelen, Morris A. Swertz, Lude Franke
Published in: Nature Genetics, Issue 50/4, 2018, Page(s) 493-497, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-018-0089-9

Integrating GWAS with bulk and single-cell RNA-sequencing reveals a role for LY86 in the anti-Candida host response

Author(s): Dylan H. de Vries, Vasiliki Matzaraki, Olivier B. Bakker, Harm Brugge, Harm-Jan Westra, Mihai G. Netea, Lude Franke, Vinod Kumar, Monique G. P. van der Wijst
Published in: PLOS Pathogens, Issue 16/4, 2020, Page(s) e1008408, ISSN 1553-7374
Publisher: Public Library of Science
DOI: 10.1371/journal.ppat.1008408