Defining how environmental factors influence downstream effects of immune-mediated disease risk-SNPs

Publikacje

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Autorzy: Urmo Võsa, Annique Claringbould, Harm-Jan Westra, Marc Jan Bonder, Patrick Deelen, Biao Zeng, Holger Kirsten, Ashis Saha, Roman Kreuzhuber, Seyhan Yazar, Harm Brugge, Roy Oelen, Dylan H. de Vries, Monique G. P. van der Wijst, Silva Kasela, Natalia Pervjakova, Isabel Alves, Marie-Julie Favé, Mawussé Agbessi, Mark W. Christiansen, Rick Jansen, Ilkka Seppälä, Lin Tong, Alexander Teumer, Katharin
Opublikowane w: Nature Genetics, Numer 53/9, 2021, Strona(/y) 1300-1310, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-021-00913-z

Improving the diagnostic yield of exome- sequencing by predicting gene–phenotype associations using large-scale gene expression analysis

Autorzy: Patrick Deelen, Sipko van Dam, Johanna C. Herkert, Juha M. Karjalainen, Harm Brugge, Kristin M. Abbott, Cleo C. van Diemen, Paul A. van der Zwaag, Erica H. Gerkes, Evelien Zonneveld-Huijssoon, Jelkje J. Boer-Bergsma, Pytrik Folkertsma, Tessa Gillett, K. Joeri van der Velde, Roan Kanninga, Peter C. van den Akker, Sabrina Z. Jan, Edgar T. Hoorntje, Wouter P. te Rijdt, Yvonne J. Vos, Jan D. H. Jongbl
Opublikowane w: Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-019-10649-4

Translational insights from single-cell technologies across the cardiovascular disease continuum

Autorzy: Irene V. van Blokland, Hilde E. Groot, Lude H. Franke, Monique G.P. van der Wijst, Pim van der Harst
Opublikowane w: Trends in Cardiovascular Medicine, 2021, ISSN 1050-1738
Wydawca: Elsevier BV
DOI: 10.1016/j.tcm.2021.02.009

The single-cell eQTLGen consortium

Autorzy: MGP van der Wijst, DH de Vries, HE Groot, G Trynka, CC Hon, MJ Bonder, O Stegle, MC Nawijn, Y Idaghdour, P van der Harst, CJ Ye, J Powell, FJ Theis, A Mahfouz, M Heinig, L Franke
Opublikowane w: eLife, Numer 9, 2020, ISSN 2050-084X
Wydawca: eLife Sciences Publications
DOI: 10.7554/elife.52155

Correction for both common and rare cell types in blood is important to identify genes that correlate with age

Autorzy: Damiano Pellegrino-Coppola, Annique Claringbould, Maartje Stutvoet, Dorret I. Boomsma, M. Arfan Ikram, P. Eline Slagboom, Harm-Jan Westra, Lude Franke
Opublikowane w: BMC Genomics, Numer 22/1, 2021, ISSN 1471-2164
Wydawca: BioMed Central
DOI: 10.1186/s12864-020-07344-w

Overlapping SETBP1 gain-of-function mutations in Schinzel-Giedion syndrome and hematologic malignancies

Autorzy: Rocio Acuna-Hidalgo, Pelagia Deriziotis, Marloes Steehouwer, Christian Gilissen, Sarah A. Graham, Sipko van Dam, Julie Hoover-Fong, Aida B. Telegrafi, Anne Destree, Robert Smigiel, Lindsday A. Lambie, Hülya Kayserili, Umut Altunoglu, Elisabetta Lapi, Maria Luisa Uzielli, Mariana Aracena, Banu G. Nur, Ercan Mihci, Lilia M. A. Moreira, Viviane Borges Ferreira, Dafne D. G. Horovitz, Katia M. da Roch
Opublikowane w: PLOS Genetics, Numer 13/3, 2017, Strona(/y) e1006683, ISSN 1553-7404
Wydawca: Public Library of Science
DOI: 10.1371/journal.pgen.1006683

Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs

Autorzy: Monique G. P. van der Wijst, Harm Brugge, Dylan H. de Vries, Patrick Deelen, Morris A. Swertz, Lude Franke
Opublikowane w: Nature Genetics, Numer 50/4, 2018, Strona(/y) 493-497, ISSN 1061-4036
Wydawca: Nature Publishing Group
DOI: 10.1038/s41588-018-0089-9

Integrating GWAS with bulk and single-cell RNA-sequencing reveals a role for LY86 in the anti-Candida host response

Autorzy: Dylan H. de Vries, Vasiliki Matzaraki, Olivier B. Bakker, Harm Brugge, Harm-Jan Westra, Mihai G. Netea, Lude Franke, Vinod Kumar, Monique G. P. van der Wijst
Opublikowane w: PLOS Pathogens, Numer 16/4, 2020, Strona(/y) e1008408, ISSN 1553-7374
Wydawca: Public Library of Science
DOI: 10.1371/journal.ppat.1008408

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