Unravelling cross-presentation pathways using a chemical biology approach

Project Information

Crosstag

Grant agreement ID: 639005

DOI 10.3030/639005

Project closed

EC signature date 11 March 2015

Start date 1 May 2015

End date 30 April 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 500 000,00

EU contribution € 1 500 000,00

Coordinated by

UNIVERSITEIT LEIDEN
Netherlands

Publications

Peer reviewed articles (19)

Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation

Author(s): Frank Versluis, Daphne M. van Elsland, Serhii Mytnyk, Dayinta L. Perrier, Fanny Trausel, Jos M. Poolman, Chandan Maity, Vincent A. A. le Sage, Sander I. van Kasteren, Jan H. van Esch, Rienk Eelkema
Published in: Journal of the American Chemical Society, Issue 138/28, 2016, Page(s) 8670-8673, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.6b03853

The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes

Author(s): Joanna B. Pawlak, Brett J. Hos, Michel J. van de Graaff, Otty A. Megantari, Nico Meeuwenoord, Herman S. Overkleeft, Dmitri V. Filippov, Ferry Ossendorp, Sander I. van Kasteren
Published in: ACS Chemical Biology, Issue 11/11, 2016, Page(s) 3172-3178, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.6b00498

Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein

Author(s): S. Anwar Jagessar, Inge R. Holtman, Sam Hofman, Elena Morandi, Nicole Heijmans, Jon D. Laman, Bruno Gran, Bart W. Faber, Sander I. van Kasteren, Bart J. L. Eggen, Bert A. ‘t Hart
Published in: The Journal of Immunology, Issue 197/4, 2016, Page(s) 1074-1088, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1600124

Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes

Author(s): Daphne M. van Elsland, Erik Bos, Wouter de Boer, Herman S. Overkleeft, Abraham J. Koster, Sander I. van Kasteren
Published in: Chem. Sci., Issue 7/1, 2016, Page(s) 752-758, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/C5SC02905H

Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

Author(s): Joanna B. Pawlak, Geoffroy P. P. Gential, Tracy J. Ruckwardt, Jessica S. Bremmers, Nico J. Meeuwenoord, Ferry A. Ossendorp, Herman S. Overkleeft, Dmitri V. Filippov, Sander I. van Kasteren
Published in: Angewandte Chemie International Edition, Issue 54/19, 2015, Page(s) 5628-5631, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201500301

Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes

Author(s): Thomas Bakkum, Tyrza van Leeuwen, Alexi J. C. Sarris, Daphne M. van Elsland, Dimitrios Poulcharidis, Herman S. Overkleeft, Sander I. van Kasteren
Published in: ACS Chemical Biology, Issue 13/5, 2018, Page(s) 1173-1179, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.8b00355

Imaging Bioorthogonal Groups in Their Ultrastructural Context with Electron Microscopy

Author(s): Daphne M. van Elsland, Sander I. van Kasteren
Published in: Angewandte Chemie International Edition, Issue 55/33, 2016, Page(s) 9472-9473, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201604672

A flow cytometry assay to quantify intercellular exchange of membrane components

Author(s): Dimitrios Poulcharidis, Kimberley Belfor, Alexander Kros, Sander I. van Kasteren
Published in: Chemical Science, Issue 8/8, 2017, Page(s) 5585-5590, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c7sc00260b

Chemical Tools for Studying TLR Signaling Dynamics

Author(s): Timo Oosenbrug, Michel J. van de Graaff, Maaike E. Ressing, Sander I. van Kasteren
Published in: Cell Chemical Biology, Issue 24/7, 2017, Page(s) 801-812, ISSN 2451-9456
Publisher: Elsevier
DOI: 10.1016/j.chembiol.2017.05.022

Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System

Author(s): Mikkel H. S. Marqvorsen, Can Araman, Sander I. van Kasteren
Published in: Bioconjugate Chemistry, Issue 30/11, 2019, Page(s) 2715-2726, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00588

Amyloid-like Behavior of Site-Specifically Citrullinated Myelin Oligodendrocyte Protein (MOG) Peptide Fragments inside EBV-Infected B-Cells Influences Their Cytotoxicity and Autoimmunogenicity

Author(s): Can Araman, Miriam E. van Gent, Nico J. Meeuwenoord, Nicole Heijmans, Mikkel H. S. Marqvorsen, Ward Doelman, Bart W. Faber, Bert A. ’t Hart, Sander I. Van Kasteren
Published in: Biochemistry, Issue 58/6, 2018, Page(s) 763-775, ISSN 0006-2960
Publisher: American Chemical Society
DOI: 10.1021/acs.biochem.8b00852

Ultrastructural Imaging of Salmonella -Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens

Author(s): Daphne M. van Elsland, Sílvia Pujals, Thomas Bakkum, Erik Bos, Nikolaos Oikonomeas-Koppasis, Ilana Berlin, Jacques Neefjes, Annemarie H. Meijer, Abraham J. Koster, Lorenzo Albertazzi, Sander I. van Kasteren
Published in: ChemBioChem, Issue 19/16, 2018, Page(s) 1766-1770, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800230

Localization of active endogenous and exogenous β‐glucocerebrosidase by correlative light‐electron microscopy in human fibroblasts

Author(s): Eline van Meel, Erik Bos, Martijn J. C. van der Lienden, Herman S. Overkleeft, Sander I. van Kasteren, Abraham J. Koster, Johannes M. F. G. Aerts
Published in: Traffic, Issue 20/5, 2019, Page(s) 346-356, ISSN 1398-9219
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/tra.12641

Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation

Author(s): Elmer Maurits, Michel J. van de Graaff, Santina Maiorana, Dennis P. A. Wander, Patrick M. Dekker, Sabina Y. van der Zanden, Bogdan I. Florea, Jacques J. C. Neefjes, Herman S. Overkleeft, Sander I. van Kasteren
Published in: Journal of the American Chemical Society, Issue 142/16, 2020, Page(s) 7250-7253, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.9b11969

Fluorogenic Bifunctional trans ‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics

Author(s): Mark A. R. Geus, Elmer Maurits, Alexi J. C. Sarris, Thomas Hansen, Max S. Kloet, Kiki Kamphorst, Wolter Hoeve, Marc S. Robillard, Andrea Pannwitz, Sylvestre A. Bonnet, Jeroen D. C. Codée, Dmitri V. Filippov, Herman S. Overkleeft, Sander I. Kasteren
Published in: Chemistry – A European Journal, Issue 26/44, 2020, Page(s) 9900-9904, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905446

Conditionally Controlling Human TLR2 Activity via Trans-Cyclooctene Caged Ligands

Author(s): Michel J. van de Graaff, Timo Oosenbrug, Mikkel H. S. Marqvorsen, Clarissa R. Nascimento, Mark A. R. de Geus, Bénédicte Manoury, Maaike E. Ressing, Sander I. van Kasteren
Published in: Bioconjugate Chemistry, Issue 31/6, 2020, Page(s) 1685-1692, ISSN 1043-1802
Publisher: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00237

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans -Cyclooctene-Modified Epitopes

Author(s): Anouk M. F. van der Gracht, Mark A. R. de Geus, Marcel G. M. Camps, Tracy J. Ruckwardt, Alexi J. C. Sarris, Jessica Bremmers, Elmer Maurits, Joanna B. Pawlak, Michelle M. Posthoorn, Kimberly M. Bonger, Dmitri V. Filippov, Herman S. Overkleeft, Marc S. Robillard, Ferry Ossendorp, Sander I. van Kasteren
Published in: ACS Chemical Biology, Issue 13/6, 2018, Page(s) 1569-1576, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.8b00155

Efficient synthesis and enzymatic extension of an N -GlcNAz asparagine building block

Author(s): Mikkel Haarslev Schröder Marqvorsen, Sivasinthujah Paramasivam, Ward Doelman, Antony John Fairbanks, Sander Izaäk van Kasteren
Published in: Chemical Communications, Issue 55/36, 2019, Page(s) 5287-5290, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc02051a

Fast and pH‐Independent Elimination of trans ‐Cyclooctene by Using Aminoethyl‐Functionalized Tetrazines

Author(s): Alexi J. C. Sarris, Thomas Hansen, Mark A. R. de Geus, Elmer Maurits, Ward Doelman, Herman S. Overkleeft, Jeroen D. C. Codée, Dmitri V. Filippov, Sander I. van Kasteren
Published in: Chemistry – A European Journal, Issue 24/68, 2018, Page(s) 18075-18081, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201803839