Unravelling cross-presentation pathways using a chemical biology approach

Informazioni relative al progetto

Crosstag

ID dell’accordo di sovvenzione: 639005

DOI 10.3030/639005

Progetto chiuso

Data della firma CE 11 Marzo 2015

Data di avvio 1 Maggio 2015

Data di completamento 30 Aprile 2020

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 500 000,00

Contributo UE € 1 500 000,00

Coordinato da

UNIVERSITEIT LEIDEN
Netherlands

Pubblicazioni

Peer reviewed articles (19)

Negatively Charged Lipid Membranes Catalyze Supramolecular Hydrogel Formation

Autori: Frank Versluis, Daphne M. van Elsland, Serhii Mytnyk, Dayinta L. Perrier, Fanny Trausel, Jos M. Poolman, Chandan Maity, Vincent A. A. le Sage, Sander I. van Kasteren, Jan H. van Esch, Rienk Eelkema
Pubblicato in: Journal of the American Chemical Society, Numero 138/28, 2016, Pagina/e 8670-8673, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.6b03853

The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes

Autori: Joanna B. Pawlak, Brett J. Hos, Michel J. van de Graaff, Otty A. Megantari, Nico Meeuwenoord, Herman S. Overkleeft, Dmitri V. Filippov, Ferry Ossendorp, Sander I. van Kasteren
Pubblicato in: ACS Chemical Biology, Numero 11/11, 2016, Pagina/e 3172-3178, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.6b00498

Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein

Autori: S. Anwar Jagessar, Inge R. Holtman, Sam Hofman, Elena Morandi, Nicole Heijmans, Jon D. Laman, Bruno Gran, Bart W. Faber, Sander I. van Kasteren, Bart J. L. Eggen, Bert A. ‘t Hart
Pubblicato in: The Journal of Immunology, Numero 197/4, 2016, Pagina/e 1074-1088, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1600124

Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes

Autori: Daphne M. van Elsland, Erik Bos, Wouter de Boer, Herman S. Overkleeft, Abraham J. Koster, Sander I. van Kasteren
Pubblicato in: Chem. Sci., Numero 7/1, 2016, Pagina/e 752-758, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/C5SC02905H

Bioorthogonal Deprotection on the Dendritic Cell Surface for Chemical Control of Antigen Cross-Presentation

Autori: Joanna B. Pawlak, Geoffroy P. P. Gential, Tracy J. Ruckwardt, Jessica S. Bremmers, Nico J. Meeuwenoord, Ferry A. Ossendorp, Herman S. Overkleeft, Dmitri V. Filippov, Sander I. van Kasteren
Pubblicato in: Angewandte Chemie International Edition, Numero 54/19, 2015, Pagina/e 5628-5631, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201500301

Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes

Autori: Thomas Bakkum, Tyrza van Leeuwen, Alexi J. C. Sarris, Daphne M. van Elsland, Dimitrios Poulcharidis, Herman S. Overkleeft, Sander I. van Kasteren
Pubblicato in: ACS Chemical Biology, Numero 13/5, 2018, Pagina/e 1173-1179, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.8b00355

Imaging Bioorthogonal Groups in Their Ultrastructural Context with Electron Microscopy

Autori: Daphne M. van Elsland, Sander I. van Kasteren
Pubblicato in: Angewandte Chemie International Edition, Numero 55/33, 2016, Pagina/e 9472-9473, ISSN 1433-7851
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201604672

A flow cytometry assay to quantify intercellular exchange of membrane components

Autori: Dimitrios Poulcharidis, Kimberley Belfor, Alexander Kros, Sander I. van Kasteren
Pubblicato in: Chemical Science, Numero 8/8, 2017, Pagina/e 5585-5590, ISSN 2041-6520
Editore: Royal Society of Chemistry
DOI: 10.1039/c7sc00260b

Chemical Tools for Studying TLR Signaling Dynamics

Autori: Timo Oosenbrug, Michel J. van de Graaff, Maaike E. Ressing, Sander I. van Kasteren
Pubblicato in: Cell Chemical Biology, Numero 24/7, 2017, Pagina/e 801-812, ISSN 2451-9456
Editore: Elsevier
DOI: 10.1016/j.chembiol.2017.05.022

Going Native: Synthesis of Glycoproteins and Glycopeptides via Native Linkages To Study Glycan-Specific Roles in the Immune System

Autori: Mikkel H. S. Marqvorsen, Can Araman, Sander I. van Kasteren
Pubblicato in: Bioconjugate Chemistry, Numero 30/11, 2019, Pagina/e 2715-2726, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.9b00588

Amyloid-like Behavior of Site-Specifically Citrullinated Myelin Oligodendrocyte Protein (MOG) Peptide Fragments inside EBV-Infected B-Cells Influences Their Cytotoxicity and Autoimmunogenicity

Autori: Can Araman, Miriam E. van Gent, Nico J. Meeuwenoord, Nicole Heijmans, Mikkel H. S. Marqvorsen, Ward Doelman, Bart W. Faber, Bert A. ’t Hart, Sander I. Van Kasteren
Pubblicato in: Biochemistry, Numero 58/6, 2018, Pagina/e 763-775, ISSN 0006-2960
Editore: American Chemical Society
DOI: 10.1021/acs.biochem.8b00852

Ultrastructural Imaging of Salmonella -Host Interactions Using Super-resolution Correlative Light-Electron Microscopy of Bioorthogonal Pathogens

Autori: Daphne M. van Elsland, Sílvia Pujals, Thomas Bakkum, Erik Bos, Nikolaos Oikonomeas-Koppasis, Ilana Berlin, Jacques Neefjes, Annemarie H. Meijer, Abraham J. Koster, Lorenzo Albertazzi, Sander I. van Kasteren
Pubblicato in: ChemBioChem, Numero 19/16, 2018, Pagina/e 1766-1770, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.201800230

Localization of active endogenous and exogenous β‐glucocerebrosidase by correlative light‐electron microscopy in human fibroblasts

Autori: Eline van Meel, Erik Bos, Martijn J. C. van der Lienden, Herman S. Overkleeft, Sander I. van Kasteren, Abraham J. Koster, Johannes M. F. G. Aerts
Pubblicato in: Traffic, Numero 20/5, 2019, Pagina/e 346-356, ISSN 1398-9219
Editore: Blackwell Publishing Inc.
DOI: 10.1111/tra.12641

Immunoproteasome Inhibitor–Doxorubicin Conjugates Target Multiple Myeloma Cells and Release Doxorubicin upon Low-Dose Photon Irradiation

Autori: Elmer Maurits, Michel J. van de Graaff, Santina Maiorana, Dennis P. A. Wander, Patrick M. Dekker, Sabina Y. van der Zanden, Bogdan I. Florea, Jacques J. C. Neefjes, Herman S. Overkleeft, Sander I. van Kasteren
Pubblicato in: Journal of the American Chemical Society, Numero 142/16, 2020, Pagina/e 7250-7253, ISSN 0002-7863
Editore: American Chemical Society
DOI: 10.1021/jacs.9b11969

Fluorogenic Bifunctional trans ‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics

Autori: Mark A. R. Geus, Elmer Maurits, Alexi J. C. Sarris, Thomas Hansen, Max S. Kloet, Kiki Kamphorst, Wolter Hoeve, Marc S. Robillard, Andrea Pannwitz, Sylvestre A. Bonnet, Jeroen D. C. Codée, Dmitri V. Filippov, Herman S. Overkleeft, Sander I. Kasteren
Pubblicato in: Chemistry – A European Journal, Numero 26/44, 2020, Pagina/e 9900-9904, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201905446

Conditionally Controlling Human TLR2 Activity via Trans-Cyclooctene Caged Ligands

Autori: Michel J. van de Graaff, Timo Oosenbrug, Mikkel H. S. Marqvorsen, Clarissa R. Nascimento, Mark A. R. de Geus, Bénédicte Manoury, Maaike E. Ressing, Sander I. van Kasteren
Pubblicato in: Bioconjugate Chemistry, Numero 31/6, 2020, Pagina/e 1685-1692, ISSN 1043-1802
Editore: American Chemical Society
DOI: 10.1021/acs.bioconjchem.0c00237

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans -Cyclooctene-Modified Epitopes

Autori: Anouk M. F. van der Gracht, Mark A. R. de Geus, Marcel G. M. Camps, Tracy J. Ruckwardt, Alexi J. C. Sarris, Jessica Bremmers, Elmer Maurits, Joanna B. Pawlak, Michelle M. Posthoorn, Kimberly M. Bonger, Dmitri V. Filippov, Herman S. Overkleeft, Marc S. Robillard, Ferry Ossendorp, Sander I. van Kasteren
Pubblicato in: ACS Chemical Biology, Numero 13/6, 2018, Pagina/e 1569-1576, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.8b00155

Efficient synthesis and enzymatic extension of an N -GlcNAz asparagine building block

Autori: Mikkel Haarslev Schröder Marqvorsen, Sivasinthujah Paramasivam, Ward Doelman, Antony John Fairbanks, Sander Izaäk van Kasteren
Pubblicato in: Chemical Communications, Numero 55/36, 2019, Pagina/e 5287-5290, ISSN 1359-7345
Editore: Royal Society of Chemistry
DOI: 10.1039/c9cc02051a

Fast and pH‐Independent Elimination of trans ‐Cyclooctene by Using Aminoethyl‐Functionalized Tetrazines

Autori: Alexi J. C. Sarris, Thomas Hansen, Mark A. R. de Geus, Elmer Maurits, Ward Doelman, Herman S. Overkleeft, Jeroen D. C. Codée, Dmitri V. Filippov, Sander I. van Kasteren
Pubblicato in: Chemistry – A European Journal, Numero 24/68, 2018, Pagina/e 18075-18081, ISSN 0947-6539
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201803839