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Epigenetic regulation of endocrine therapy resistance in breast cancer: A systems medicine approach to predict treatment outcome

Ziel

The mission of EpiPredict is to train a multidisciplinary cohort of young researchers in a new approach to fully exploit the epigenetics of complex diseases. The 12 early-stage researchers (ESRs) will focus on a narrowly defined case, Tamoxifen-induced resistance in Estrogen Receptor positive (ER+) breast cancer, considering five resistance interacting pathways. Given the frequent Tamoxifen treatment failure, resistance prevention and reversal is an urgent clinical problem that is central in EpiPredict. The EpiPredict intersectorial training programme employs a timely systems medicine approach combining next-generation systematic epigenetic, gene/protein profiling with innovative gene-specific epigenetic interference technologies for iterative computational modelling. Together the ESRs will identify key epigenetic changes underlying Tamoxifen induced resistance. This will provide an important step towards diagnostic markers/tools to predict treatment outcome and response monitoring setting the scene for breast cancer personalized medicine. The fellows will be trained by experts from 6 academic and 2 non-academic beneficiaries and 7 partner organizations (1 academic, 6 non-academic including industrial/socio-public parties) and 5 visiting scientists, from fields ranging from epigenetics to both computation and medicine. Strong involvement of the private sector ensures exploitation of EpiPredict achievements and exposure of the ESRs to an entrepreneurial mindset.
The cohort of supradisciplinary researchers represents a new generation of research leaders equipped to address complex diseases whilst taking personalized patient aspects into consideration. They will be equipped to compete successfully and succeed in their personal careers. EpiPredict will boost academia and pharma/biotech environments, providing extra impulses to drive European translational science, systems medicine, pharmaceutical industry, and Medical ICT offering ample job opportunities.

Wissenschaftliches Gebiet

  • /Naturwissenschaften/Biowissenschaften/Genetik und Vererbung/DNS
  • /Naturwissenschaften/Biowissenschaften/Biochemie/Biomoleküle/Proteine
  • /Medizin- und Gesundheitswissenschaften/Grundlagenmedizin/Pharmakologie und Pharmazie/Arzneimittelresistenz
  • /Medizin- und Gesundheitswissenschaften/Klinische Medizin/Onkologie/Krebs/Brustkrebs
  • /Naturwissenschaften/Biowissenschaften/Genetik und Vererbung/Epigenetik

Aufforderung zur Vorschlagseinreichung

H2020-MSCA-ITN-2014
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MSCA-ITN-ETN - European Training Networks

Koordinator

UNIVERSITEIT VAN AMSTERDAM
Adresse
Spui 21
1012WX Amsterdam
Niederlande
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 766 122,84

Beteiligte (7)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU-Beitrag
€ 546 575,76
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London
Aktivitätstyp
Higher or Secondary Education Establishments
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Deutschland
EU-Beitrag
€ 498 432,96
Adresse
Im Neuenheimer Feld 280
69120 Heidelberg
Aktivitätstyp
Research Organisations
UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA
Italien
EU-Beitrag
€ 258 061,32
Adresse
Piazza Dell'ateneo Nuovo 1
20126 Milano
Aktivitätstyp
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Niederlande
EU-Beitrag
€ 255 374,28
Adresse
Hanzeplein 1
9713 GZ Groningen
Aktivitätstyp
Higher or Secondary Education Establishments
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Ungarn
EU-Beitrag
€ 223 913,52
Adresse
Temesvari Korut 62
6726 Szeged
Aktivitätstyp
Research Organisations
Epiontis GmbH
Deutschland
EU-Beitrag
€ 249 216,48
Adresse
Rudower Chaussee 29
12489 Berlin
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CLINICAGENO LIMITED

Beteiligung beendet

United Kingdom
EU-Beitrag
€ 0
Adresse
Station Approach 11 Coulsdon North
CR5 2NR Coulsdon Surrey
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partner (7)

Synvolux Therapeutics BV
Niederlande
Adresse
Jh Oortweg 19
2333 CH Leiden
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK
Schweden
Adresse
Chalmers Science Park
41288 Goeteborg
Aktivitätstyp
Research Organisations
FH JOANNEUM GESELLSCHAFT MBH
Österreich
Adresse
Alte Poststrasse 149
8020 Graz
Aktivitätstyp
Higher or Secondary Education Establishments
AHT Management Kft
Ungarn
Adresse

Budapest
Aktivitätstyp
Other
Rathenau Instituut
Niederlande
Adresse

Amsterdam
Aktivitätstyp
Other
Biotecture
Niederlande
Adresse
Rudolf Dieselstraat 80-Hs
1097 AZ Amsterdam
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Schweiz
Adresse
Raemistrasse 101
8092 Zuerich
Aktivitätstyp
Higher or Secondary Education Establishments