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Engineering of new-generation protein secretion systems

Objective

The market for recombinant proteins, including biopharmaceuticals, industrial enzymes and membrane proteins, is estimated to be about 78 billion Euro and rising. A high proportion of the target proteins are produced in bacteria, where secretion out of the cytoplasm is a favoured strategy. However, current production platforms have severe limitations and cannot handle many secreted enzymes and membrane proteins. There is an overwhelming need for new production systems that can deliver these products in greater yields, with higher quality and at lower costs. The 'ProteinFactory' ETN will meet these challenges through the provision of a suite of super-secreting strains with unique capabilities. These strains will be engineered to bypass major production bottlenecks such as secretion stress, and will be capable of secreting an unprecedented range of target molecules. Equally important will be the training of a new generation of researchers, versed in Systems and Synthetic Biology approaches. The ProteinFactory project will involve extensive collaboration between 6 academic Institutes, who provide world-leading expertise in synthetic biology and protein secretion, and 5 non-academic partners who include some of the world's premier biotechnology companies. Training will be inter-sectoral from the outset, with every ESR undertaking extensive secondments within the non-academic partners in order to encourage an entrepreneurial mind-set. The project is furthermore explicitly multi-disciplinary in scope, with two of the five research work packages dominated by theoretical approaches. Based on a responsible innovation approach and with a clear focus on inter-sectoral collaboration, ProteinFactory will deliver a cohort of superbly-trained scientists, put the industrial and SME partners at the forefront of global competition and reinforce European innovation potentials with growth and job creation.

Field of science

  • /social sciences/economics and business/business and management/commerce
  • /natural sciences/biological sciences/synthetic biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-MSCA-ITN-2014
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Address
Hanzeplein 1
9713 GZ Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 383 061,42

Participants (9)

UNIVERSITY OF KENT
United Kingdom
EU contribution
€ 546 575,76
Address
The Registry Canterbury
CT2 7NZ Canterbury, Kent
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 525 751,20
Address
Rue De L'universite 147
75338 Paris Cedex 07
Activity type
Research Organisations
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 790 977,96
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
EU contribution
€ 249 216,48
Address
Unter Den Linden 6
10117 Berlin
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 498 432,96
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
NOVOZYMES A/S
Denmark
EU contribution
€ 290 081,88
Address
Krogshoejvej 36
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DSM FOOD SPECIALTIES BV
Netherlands
EU contribution
€ 127 687,14
Address
Alexander Fleminglaan 1
2613 AX Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UCB PHARMA SA
Belgium
EU contribution
€ 0
Address
Allee De La Recherche 60
1070 Bruxelles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELLTECH R&D LIMITED
United Kingdom
EU contribution
€ 273 287,88
Address
208 Bath Road
SL1 3WE Slough
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (1)

ABERA BIOSCIENCE AB
Sweden
Address

Stockholm
Activity type
Other