Objective Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines. It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8+ T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesmedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being Main Programme H2020-EU.3.1.2. - Preventing disease Topic(s) PHC-08-2014 - Vaccine development for poverty-related and neglected infectious diseases: tuberculosis Call for proposal H2020-PHC-2014-2015 See other projects for this call Sub call H2020-PHC-2014-single-stage Funding Scheme RIA - Research and Innovation action Coordinator ST GEORGE'S HOSPITAL MEDICAL SCHOOL Net EU contribution € 2 235 080,00 Address CRANMER TERRACE SW17 0RE London United Kingdom See on map Region London Inner London — West Wandsworth Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 2 235 117,50 Participants (13) Sort alphabetically Sort by Net EU contribution Expand all Collapse all KING'S COLLEGE LONDON United Kingdom Net EU contribution € 363 586,00 Address STRAND WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 363 586,36 KAROLINSKA INSTITUTET Sweden Net EU contribution € 970 037,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 971 937,50 UNIVERSIDAD DE VIGO Spain Net EU contribution € 670 000,00 Address LG CAMPUS LAGOAS MARCOSENDE 36310 Vigo Pontevedra See on map Region Noroeste Galicia Pontevedra Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 670 468,75 LIONEX GMBH Germany Net EU contribution € 408 350,00 Address Salzdahlumer Strasse 196 38126 Braunschweig See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 408 875,00 AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO Italy Net EU contribution € 320 000,00 Address VIA DEL VESPRO 129 90127 Palermo See on map Region Isole Sicilia Palermo Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 320 000,00 SPOREGEN LIMITED United Kingdom Net EU contribution € 436 047,00 Address THE LONDON BIOSCIENCE INNOVATION CENTRE 2 ROYAL COLLEGE STREET NW1 0NH LONDON See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region London Inner London — West Camden and City of London Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 436 447,50 STOCKHOLMS UNIVERSITET Sweden Net EU contribution € 333 350,00 Address UNIVERSITETSVAGEN 10 10691 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 333 875,00 AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain Net EU contribution € 323 036,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 323 036,25 UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA Italy Net EU contribution € 320 132,00 Address VIA CRACOVIA 50 00133 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 320 132,50 INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL Spain Net EU contribution € 184 792,00 Address CTRA DE CANYET S/N 08916 Badalona Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 184 792,50 Department of Health United Kingdom Net EU contribution € 824 657,00 Address Quarry House, Quarry Hill LS2 7UE Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 826 532,50 Instituto Nacional de Saúde Mozambique Net EU contribution € 454 593,00 Address Avenida Eduardo Mondlane 1008 Maputo See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 455 118,75 MIKROBIOLOGICKY USTAV AV CR V.V.I Czechia Net EU contribution € 150 000,00 Address VIDENSKA 1083 142 00 Praha 4 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 150 000,00
