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Eliciting Mucosal Immunity to Tuberculosis

Objective

Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines. It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8+ T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen.

Field of science

  • /medical and health sciences/health sciences/public and environmental health/epidemics prevention/immunisation
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

H2020-PHC-2014-single-stage
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Address
Cranmer Terrace
SW17 0RE London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 235 080

Participants (13)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 363 586
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 970 037
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE VIGO
Spain
EU contribution
€ 670 000
Address
Lg Campus Lagoas Marcosende
36310 Vigo Pontevedra
Activity type
Higher or Secondary Education Establishments
LIONEX GMBH
Germany
EU contribution
€ 408 350
Address
Salzdahlumer Strasse 196
38126 Braunschweig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO
Italy
EU contribution
€ 320 000
Address
Via Del Vespro 129
90127 Palermo
Activity type
Research Organisations
SPOREGEN LIMITED
United Kingdom
EU contribution
€ 436 047
Address
Queens Road 3 Westley Gate
RG1 4AP Reading Berkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STOCKHOLMS UNIVERSITET
Sweden
EU contribution
€ 333 350
Address
Universitetsvagen 10
10691 Stockholm
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 323 036
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 320 132
Address
Via Cracovia 50
00133 Roma
Activity type
Higher or Secondary Education Establishments
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
EU contribution
€ 184 792
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Activity type
Research Organisations
Department of Health
United Kingdom
EU contribution
€ 824 657
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Instituto Nacional de Saúde
Mozambique
EU contribution
€ 454 593
Address
Avenida Eduardo Mondlane 1008
Maputo
Activity type
Research Organisations
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
EU contribution
€ 150 000
Address
Videnska 1083
142 00 Praha 4
Activity type
Research Organisations