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Eliciting Mucosal Immunity to Tuberculosis

Objective

Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines. It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8+ T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen.

Call for proposal

H2020-PHC-2014-2015

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Sub call

H2020-PHC-2014-single-stage

Coordinator

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Net EU contribution
€ 2 235 080,00
Address
Cranmer Terrace
SW17 0RE London
United Kingdom

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Region
London Inner London — West Wandsworth
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 37,50

Participants (13)

KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 363 586,00
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,36
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 970 037,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1 900,50
UNIVERSIDAD DE VIGO
Spain
Net EU contribution
€ 670 000,00
Address
Lg Campus Lagoas Marcosende
36310 Vigo Pontevedra

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Region
Galicia Pontevedra
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 468,75
LIONEX GMBH
Germany
Net EU contribution
€ 408 350,00
Address
Salzdahlumer Strasse 196
38126 Braunschweig

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 525,00
AZIENDA OSPEDALIERA UNIVERSITARIA POLICLINICO PAOLO GIACCONE DI PALERMO
Italy
Net EU contribution
€ 320 000,00
Address
Via Del Vespro 129
90127 Palermo

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Region
Isole Sicilia Palermo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SPOREGEN LIMITED
United Kingdom
Net EU contribution
€ 436 047,00
Address
Queens Road 3 Westley Gate
RG1 4AP Reading Berkshire

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Berkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 400,50
STOCKHOLMS UNIVERSITET
Sweden
Net EU contribution
€ 333 350,00
Address
Universitetsvagen 10
10691 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 525,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 323 036,00
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,25
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
Net EU contribution
€ 320 132,00
Address
Via Cracovia 50
00133 Roma

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,50
INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Spain
Net EU contribution
€ 184 792,00
Address
Ctra De Canyet S/n
08916 Badalona Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,50
Department of Health
United Kingdom
Net EU contribution
€ 824 657,00
Address
Quarry House, Quarry Hill
LS2 7UE Leeds

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Region
Yorkshire and the Humber West Yorkshire Leeds
Activity type
Research Organisations
Non-EU contribution
€ 1 875,50
Instituto Nacional de Saúde
Mozambique
Net EU contribution
€ 454 593,00
Address
Avenida Eduardo Mondlane 1008
Maputo

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Activity type
Research Organisations
Non-EU contribution
€ 525,75
MIKROBIOLOGICKY USTAV AV CR V.V.I
Czechia
Net EU contribution
€ 150 000,00
Address
Videnska 1083
142 00 Praha 4

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Region
Praha Hlavní město Praha
Activity type
Research Organisations
Non-EU contribution
€ 0,00