Skip to main content
European Commission logo
français français
CORDIS - Résultats de la recherche de l’UE
CORDIS

Eliciting Mucosal Immunity to Tuberculosis

Objectif

Tuberculosis (TB) is a global health problem, killing 1.5 million of people every year. The only currently available vaccine, Mycobacterium bovis BCG, is effective against severe childhood forms, but it demonstrates a variable efficacy against the pulmonary form of TB in adults. Many of these adult TB cases result from the reactivation of an initially controlled, latent Mycobacterium tuberculosis (MTB) infection. Effective prophylactic vaccination remains the key long-term strategy for combating TB. Continued belief in reaching this goal requires unrelenting innovation in the formulation and delivery of candidate vaccines. It is also based on the assumption, that the failure of recent human vaccine trials could have been due to a sub-optimal vaccine design and delivery, and therefore should not erode the key principle that a TB vaccine is an attainable target. This proposal focuses on mucosal vaccination, which has been considered in the past, but not implemented efficiently. The innovation of the proposal is focused on several important aspects of vaccine development and testing, including the use of novel technologies for vaccine delivery, novel ways of specific targeting of mucosal immune cells and tissues, the use of polypeptides incorporating early and latent MTB antigens and putative CD8+ T cell epitopes, and application of novel tools for identifying early predictors and correlates of vaccine-induced protection. The overall objective is to design a vaccine that will induce a broad-ranging immune response to MTB both systemically and in the mucosa of the lungs, and provide the currently missing links in protective immunity to this pathogen.

Champ scientifique

Programme(s)

Thème(s)

Appel à propositions

H2020-PHC-2014-2015

Voir d’autres projets de cet appel

Sous appel

H2020-PHC-2014-single-stage

Régime de financement

RIA - Research and Innovation action

Coordinateur

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Contribution nette de l'UE
€ 2 235 080,00
Adresse
CRANMER TERRACE
SW17 0RE London
Royaume-Uni

Voir sur la carte
Région
London Inner London — West Wandsworth
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 2 235 117,50

Participants (13)

Partager cette page

Télécharger

Dernière mise à jour: 22 Août 2022

Mon livret

Permalink: https://cordis.europa.eu/project/id/643558/fr

European Union, 2024